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Letrozole

Indications and uses Side effects
Letrozole
Letrozole
CAS No.
112809-51-5
Chemical Name:
Letrozole
Synonyms
Letroz;FEMARA;Lelrozol;Lerozole;LETROZOL;LETRAZOLE;CGS-20267;LETROZOLE;letrozolex;Letrozole99%
CBNumber:
CB9286355
Molecular Formula:
C17H11N5
Formula Weight:
285.30274
MOL File:
112809-51-5.mol

Letrozole Properties

Melting point:
181-183°C
storage temp. 
-20°C Freezer
solubility 
DMSO: >50mg/mL
form 
White powder
color 
white to off-white
Merck 
14,5450
InChIKey
HPJKCIUCZWXJDR-UHFFFAOYSA-N
CAS DataBase Reference
112809-51-5(CAS DataBase Reference)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DI4957000
Hazardous Substances Data 112809-51-5(Hazardous Substances Data)

Letrozole price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 182541 Aromatase Inhibitor II, Letrozole 112809-51-5 25mg $119 2018-11-20 Buy
Sigma-Aldrich 1356971 Letrozole United States Pharmacopeia (USP) Reference Standard 112809-51-5 200mg $348 2018-11-13 Buy
Cayman Chemical 11568 Letrozole ≥98% 112809-51-5 10mg $35 2018-11-13 Buy
Cayman Chemical 11568 Letrozole ≥98% 112809-51-5 25mg $74 2018-11-13 Buy
Sigma-Aldrich L6545 Letrozole ≥98% (HPLC) 112809-51-5 50mg $297 2018-11-13 Buy

Letrozole Chemical Properties,Uses,Production

Indications and uses

Letrozole is part of a new generation of highly selective aromatase inhibitors and is an artificially synthesized benzotriazole derivative. Letrozole inhibits aromatase to lower estrogen levels, thus preventing estrogen from stimulating tumor growth. Its in vivo activity is 150-250 times stronger than that of first generation aromatase inhibitor Amarante. As it is highly selective, it will not impact glucocorticoid, mineralocorticoid and thyroid functions; even at high dosages, it will not have any inhibiting effects on adrenal corticosteroid secretion, giving it a high treatment index. Letrozole has no latent toxicity towards any bodily systems and target organs, has no mutagenicity and carcinogenic effects, has minimal toxic side effects, is well-tolerated, and has stronger anticancer effects than other aromatase inhibitors and antiestrogen drugs. Letrozole is suitable for advanced breast cancer postmenopausal patients who have not responded to estrogen-suppressing treatment and for early breast cancer treatment. It is used to treat postmenopausal patients with advanced breast cancer and serves as a second-line treatment to follow unsuccessful antiestrogen treatment. Compared to the current standard Tamoxifen treatment, Letrozole can better prevent the risk of breast cancer recurrence.

Side effects

Randomized grouping studies have shown that daily oral ingestion of 2.5mg Letrozole leads to a 33% rate of drug-related negative reactions, a percentage much lower than AG group’s 46%. Negative reactions to Letrozole are mostly mild or moderate, consisting mostly of nausea (2-9%), headache (0-7%), bone pain (4-10%), hot flashes (0-9%) and weight gain (2-8%). Other uncommon side effects include constipation, diarrhea, itching, rash, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, high blood pressure, arrhythmia, thrombosis, dyspnea, vaginal bleeding, etc.

Description

Letrozole (trade name: Femara) is an orally active nonsteroidal aromatase inhibitor. As a competitive inhibitor of the aromatase, Letrozole inhibits the conversion of androgens to estrogen (estrogen stimulates breast tissues and breast cancer reoccurrence) and gonadal steroidogenesis. It can be used for the treatment of breast cancer that is hormonally-responsive or has an unknown receptor status in postmenopausal women. Besides this, Letrozole also has some off-label use such as ovarian stimulation, pretreatment of termination of pregnancy, treatment of gynecomastia, treatment of endometriosis, and promoting spermatogenesis for male patients of nonobstructive azoospermia.

Chemical Properties

white to light yellow crystal

Uses

A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic

brand name

Femara (Novar tis).

References

https://www.drugbank.ca/drugs/DB01006
https://en.wikipedia.org/wiki/Letrozole

Letrozole Preparation Products And Raw materials

Raw materials

Preparation Products


Letrozole Suppliers

Global( 302)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32763 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2549 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 893 55
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 301 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 1135 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 778 58

View Lastest Price from Letrozole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-27 Letrozole
112809-51-5
US $15.00 / KG 1KG 99% 1000KG career henan chemical co

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