Florbenazine
- CAS No.
- 937245-42-6
- Chemical Name:
- Florbenazine
- Synonyms
- Florbenazine;(2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol;2H-Benzo[a]quinolizin-2-ol, 9-(3-fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
- CBNumber:
- CB93166380
- Molecular Formula:
- C21H32FNO3
- Molecular Weight:
- 365.48
- MDL Number:
- MOL File:
- 937245-42-6.mol
| Boiling point | 496.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.14±0.1 g/cm3(Predicted) |
| pka | 14.75±0.40(Predicted) |
| InChI | InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1 |
| InChIKey | GNKGXQHHUUEYQV-BHIYHBOVSA-N |
| SMILES | C12=CC(OC)=C(OCCCF)C=C1CCN1[C@]2([H])C[C@@H](O)[C@H](CC(C)C)C1 |
| FDA UNII | K5GDY88W5X |
Florbenazine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA021I49 | (2R,3R,11bR)-9-(3-Fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol 95% | 937245-42-6 | 1mg | $415 | 2026-06-01 | Buy |
| aablocks | AA021I49 | (2R,3R,11bR)-9-(3-Fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol 95% | 937245-42-6 | 5mg | $1184 | 2026-06-01 | Buy |
| aablocks | AA021I49 | (2R,3R,11bR)-9-(3-Fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol 95% | 937245-42-6 | 10mg | $1954 | 2026-06-01 | Buy |
Florbenazine Chemical Properties, Uses, Production
Description
Florbenazine (AV-133) is a fluorinated VMAT-2 ligand for PET. It is designed to measure dopaminergic degeneration by in vivo assessment of striat VMAT2 density in patients with Parkinson’s disease (PD). Besides differentiating PD from essential tremor and drug-induced parkinsonism, PET imaging of VMAT2 may help in differentiating Dementia with Lewy Bodies (DLB) from Alzheimer’s disease. AV-45 (florbetapir, AmyvidTM) is the first PET ligand to receive US FDA approval to assess neuritic plaque amyloid[1-2].
Uses
Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease)[1].
References
[1] Andrew Siderowf. “PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer’s disease and Lewy body disorders.” BMC Neurology 14 (2014): 79.
[2] Harsh V Gupta. “Clinicopathological Correlation: Dopamine and Amyloid PET Imaging with Neuropathology in Three Subjects Clinically Diagnosed with Alzheimer’s Disease or Dementia with Lewy Bodies.” Journal of Alzheimer’s Disease 80 4 (2021): 1603–1612.
Florbenazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 | 3321478047@qq.com | China | 2002 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 9995 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
