ChemicalBook >> CAS DataBase List >>4-Methylhistamine dihydrochloride
4-Methylhistamine dihydrochloride
- CAS No.
- 36376-47-3
- Chemical Name:
- 4-Methylhistamine dihydrochloride
- Synonyms
- SKF-71517;4-Methylhistamine di;4-Methylhistamine DiHCl;4-METHYLHISTAMINE DIHYDROCHLORIDE;5-Methylhistamine dihydrochloride;4-Methylhistamine (hydrochloride);Methylhistamine dihydrochloride, 4-;2-(4-methyl-1H-imidazol-5-yl)ethanamine;5-Methyl-1H-imidazole-4-ethanamine dihydrochloride;4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
- CBNumber:
- CB9838358
- Molecular Formula:
- C6H14Cl2N3
- Molecular Weight:
- 199.10146
- MDL Number:
- MFCD01721796
- MOL File:
- 36376-47-3.mol
Last updated:2023-06-30 15:45:59
| Melting point | 231-233℃ (ethanol ) |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Beige |
| Water Solubility | Soluble to 50 mM in water |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
4-Methylhistamine dihydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23761 | 4-Methylhistamine (hydrochloride) ≥95% | 36376-47-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23761 | 4-Methylhistamine (hydrochloride) ≥95% | 36376-47-3 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 23761 | 4-Methylhistamine (hydrochloride) ≥95% | 36376-47-3 | 10mg | $199 | 2024-03-01 | Buy |
| Tocris | 2342 | 4-Methylhistaminedihydrochloride | 36376-47-3 | 10 | $216 | 2021-12-16 | Buy |
| Tocris | 2342 | 4-Methylhistaminedihydrochloride | 36376-47-3 | 50 | $908 | 2021-12-16 | Buy |
4-Methylhistamine dihydrochloride Chemical Properties,Uses,Production
Description
4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.
Uses
Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.
Biological Activity
4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
storage
Desiccate at RT
References
[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.
[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898.
4-Methylhistamine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methylhistamine dihydrochloride Suppliers
Global( 43)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai Hekang Biotechnology Co., Ltd. | 18939837085 | youchemicals@gmail.com | China | 1823 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
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2-(5-Methyl-4-imidazolyl)ethylamine dihydrochloride
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4-Methylhistamine (hydrochloride)
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4-Methylhistamine di
36376-47-3
Histamine receptor
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Heterocycles
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