4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
![4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Structure](CAS/GIF/35941-71-0.gif)
- CAS No.
- 35941-71-0
- Chemical Name:
- 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
- Synonyms
- Fk 1160;RHC 2592;Solantal;Nsc289337;Corensoul;Nta-194 HCl;Usv 2592 HCl;benzo[d]thiazol-2(3H);Tiaramide hydrochloride;Tiaramide hydrochloride-r
- CBNumber:
- CB9941351
- Molecular Formula:
- C15H19Cl2N3O3S
- Molecular Weight:
- 392.30066
- MDL Number:
- MFCD01702832
- MOL File:
- 35941-71-0.mol
- MSDS File:
- SDS
| Melting point | 159-161° |
|---|---|
| Water Solubility | Completely soluble in water |
| form | powder to crystal |
| color | White to Orange to Green |
| Merck | 14,9424 |
| FDA UNII | ITY1616X9T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Warning |
| Hazard statements | H318 |
| Precautionary statements | P280-P305+P351+P338-P310-P403-P501c |
| RTECS | TL7050000 |
| HS Code | 2934.20.8000 |
| Toxicity | LD50 in male mice, rats (mg/kg): 178, 203 i.v.; 298, 540 i.p.; 564, 3600 orally (Watanabe) |
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3176 | Tiaramide Hydrochloride >98.0%(T) | 35941-71-0 | 25mg | $123 | 2024-03-01 | Buy |
| TCI Chemical | T3176 | Tiaramide Hydrochloride >98.0%(T) | 35941-71-0 | 100mg | $370 | 2024-03-01 | Buy |
| TRC | T445105 | Tiaramide Hydrochloride | 35941-71-0 | 1g | $950 | 2021-12-16 | Buy |
| AK Scientific | 6762AL | Tiaramide Hydrochloride | 35941-71-0 | 25mg | $357 | 2021-12-16 | Buy |
| Chem-Impex | 38322 | Tiaramidehydrochloride,98%(AssaybyTitration) 98%(AssaybyTitration) | 35941-71-0 | 100MG | $740.32 | 2021-12-16 | Buy |
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Chemical Properties,Uses,Production
Originator
Solantal,Fujisawa,Japan,1975
Uses
Tiaramide Hydrochloride is a useful compound for treatment of gastrointestinal disease.
Definition
ChEBI: Tiaramide hydrochloride is a member of benzothiazoles.
Manufacturing Process
A solution of ethyl 5-chloro-2-oxo-3-benzo-thiazolineacetate (4.0 grams) in 1- (2-hydroxyethyl)piperazine is heated at 100°C for 24 hours. After cooling, the resulting mixture is extracted with chloroform. The chloroform extract is washed with water and shaken with 10% hydrochloric acid. The hydrochloric acid layer is washed with chloroform, made alkaline with 10% sodium hydroxide solution and extracted with chloroform. The chloroform extract is washed with water, dried over magnesium sulfate and concentrated. The residual oil (5.5 grams) is allowed to stand to form crystals, which are recrystallized from a mixture of ethyl acetate (40 ml) and ethanol (15 ml) to give 3-[4-(2-hydroxyethyl)-1-piperazinylcarbonylmethyl]-5-chloro-2(3H)- benzothiazolinone (3.2 grams) as colorless crystals, MP 159° to 161°C. The following is an alternate method of preparation: A mixture of 3-(1- piperazinyl)carbonylmethyl-5-chloro-2(3H)-benzothiazolinone (500 mg), anhydrous potassium carbonate (400 mg), 2-hydroxyethyl bromide (300 mg) and anhydrous ethanol (20 ml) is heated while refluxing for 5 hours. The reaction mixture is concentrated under reduced pressure. The residue is extracted with chloroform. The chloroform layer is dried over magnesium sulfate and concentrated. The residue is crystallized from a mixture of ethyl acetate and ethanol to give 3-[4-(2-hydroxyethyl]-1- piperazinylcarbonylmethyl]-5-chloro-2(3H)-benzothiazolinone (370 mg) as crystals, MP 159° to 160°C.
Therapeutic Function
Antiinflammatory
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Preparation Products And Raw materials
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
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| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24539 | 81 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
| Chengdu Kamel Pharmaceutical Co., Ltd | 028-67136579 15828051124 | sales@kamelpharm.com | China | 1751 | 55 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 10007 | 58 |