NS-398 化学特性,用途語,生産方法
外観
白色～わずかにうすい褐色, 結晶～粉末
溶解性
メタノールに溶ける。エタノール、DMSO及びジメチルホルムアミドに溶ける。
説明
NS-
398 is a selective inhibitor of cyclooxygenase-
2 (COX-
2). The IC
50 values for human recombinant COX-
1 and -
2 are 75 and 1.77 μM, respectively. The IC
50 values for ovine COX-
1 and -
2 are 220 and 0.15 μM, respectively.
使用
NS-398 is a selective Cox-2 inhibitor neuroprotective agent.
定義
ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
生物活性
Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
NS-398 上流と下流の製品情報
原材料
準備製品