ピルプロフェン 化学特性,用途語,生産方法
効能
抗炎症薬
使用
Pirprofen is a non-steroidal anti-inflammatory drug.
世界保健機関（WHO）
Pirprofen, a nonsteroidal anti-inflammatory agent, was introduced
in 1982 primarily for the treatment of rheumatic diseases, as well as for use in posttraumatic
and post-operative inflammatory conditions, acute gout and
dysmenorrhoea. Reports of serious adverse effects, in particular cases of liver
toxicity, some of which were fatal, led the manufacturer, in 1985 and in 1989, to
amend the approved product information of the drug, limiting duration of treatment
and lowering the recommended doses. In the light of these successive restrictions,
which have considerably reduced the field of application of pirprofen and in view of
available alternatives, the manufacturer has decided to discontinue the drug
worldwide.
合成
Synthesis: treatment of the sodium
salt of diethyl methylmalonate with 2,4-
dichloronitrobenzene yields diethyl (3-chloro-
4-nitrophenyl)methylmalonate. Saponification,
decarboxylation, and subsequent reesterification followed by catalytic reduction gives ethyl
4-amino-3-chloro-α-methylbenzeneacetate hydrochloride. Treatment of the latter with 1,4-
dichloro-2-butene in the presence of sodium
carbonate followed by saponification affords
pirprofen.
ピルプロフェン 上流と下流の製品情報
原材料
準備製品