2-メチル-4H-3,1-ベンゾオキサジン-4-オン
2-メチル-4H-3,1-ベンゾオキサジン-4-オン 物理性質
- 融点 :
- 79-82 °C(lit.)
- 沸点 :
- 144-145 °C(Press: 12 Torr)
- 比重(密度) :
- 1.25±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 酸解離定数(Pka):
- 2.84±0.20(Predicted)
- InChI:
- InChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3
- InChIKey:
- WMQSKECCMQRJRX-UHFFFAOYSA-N
- SMILES:
- N1C2=CC=CC=C2C(=O)OC=1C
- EPAの化学物質情報:
- 4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)
2-メチル-4H-3,1-ベンゾオキサジン-4-オン 価格
もっと(8)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC319973 |
2-メチル-4H-ベンゾ[d][1,3]オキサジン-4-オン
2-Methyl-4H-benzo[d][1,3]oxazin-4-one |
525-76-8 |
1g |
￥6300 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC319973 |
2-メチル-4H-ベンゾ[d][1,3]オキサジン-4-オン
2-Methyl-4H-benzo[d][1,3]oxazin-4-one |
525-76-8 |
5g |
￥14400 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC319973 |
2-Methyl-4H-benzo[d][1,3]oxazin-4-one |
525-76-8 |
25g |
￥56900 |
2021-03-23 |
購入 |
|
Sigma-Aldrich Japan
|
457752 |
2-メチル-4H-3,1-ベンゾキサジン-4-オン 98%
2-Methyl-4H-3,1-benzoxazin-4-one 98% |
525-76-8 |
10g |
￥7980 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS061242 |
2-メチル-4H-3,1-ベンゾキサジン-4-オン
2-Methyl-4H-3,1-benzoxazin-4-one |
525-76-8 |
500mg |
￥131100 |
2024-03-01 |
購入 |
2-メチル-4H-3,1-ベンゾオキサジン-4-オン 化学特性,用途語,生産方法
外観
わずかにうすい黄色～褐黄色、結晶性粉末～粉末
使用
2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 363, 1980
DOI: 10.1021/jo01290a038
合成
In 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.
2-メチル-4H-3,1-ベンゾオキサジン-4-オン 上流と下流の製品情報
原材料
準備製品
2-メチル-4H-3,1-ベンゾオキサジン-4-オン 生産企業
Global( 125)Suppliers
525-76-8(2-メチル-4H-3,1-ベンゾオキサジン-4-オン)キーワード:
2-メチル-4H-3,1-ベンゾオキサジン-4-オン
2-フェニル-4H-3,1-ベンゾオキサジン-4-オン
2-(2-メチルフェニル)-4H-3,1-ベンゾオキサジン-4-オン
2-(p-フルオロフェニル)-4H-3,1-ベンゾオキサジン-4-オン
2-(4-ニトロフェニル)-4H-3,1-ベンゾオキサジン-4-オン
2-p-トリル-4H-3,1-ベンゾオキサジン-4-オン
2-(o-クロロフェニル)-4H-3,1-ベンゾオキサジン-4-オン
2-(3-メトキシフェニル)-3,1-ベンゾオキサジン-4-オン
2-(4-tert-ブチルフェニル)-4H-3,1-ベンゾオキサジン-4-オン
2-(3-ニトロフェニル)-4H-3,1-ベンゾオキサジン-4-オン
- 525-76-8
- TIMTEC-BB SBB000135
- 2-methyl-4h-1-benzoxazin-4-one
- 2-METHYL-3,1-BENZOXAZA-4-ONE
- 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
- ACETYL ANTHRANIL
- ACETANTHRANIL
- 2-2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
- 4H-3,1-benzoxazin-4-one, 2-methyl-
- 2-methyl-3,1-benzoxazin-4-one
- 2-Methyl-benzo(d)(1,3)oxazin-4-one
- 2-Methyl-4H-benzo[d][1,3]oxazin-4-one
- 2-Methyl-3,1-benzoxazine-4-one
- 2-Methyl-4-oxo-3,1-benzoxazine
- 2-Methyl-4-oxo-4H-3,1-benzoxazine
- 2-Methylbenzo[1,3]oxazin-4-one
- Acetylanthranyl
- NSC 10119
- NSC 521353
- 2-Methyl-4H-3,1-benzoxazin-4-one 98%
- 2-Methylbenzisoxazinone(2-Methyl-4H-3,1-Benzoxazin-4-One)
- AURORA KA-3785
- 3-methyl-1-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-dione
- 2-Methyl-4H-3,1-benzoxazin-4-o
- Ortho acetamide benzoic acid lactone
- 2-Methyl-4H-benzo [d] [1,3]oxazin-4o
- 2-メチル-4H-3,1-ベンゾオキサジン-4-オン
- アセトアントラニル
- 2-メチル-4H-3,1-ベンゾキサジン-4-オン
- 2-メチル-4H-ベンゾ[D][1,3]オキサジン-4-オン