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2-Methyl-4H-3,1-benzoxazin-4-one

2-Methyl-4H-3,1-benzoxazin-4-one 구조식 이미지

카스 번호:: 525-76-8

상품명:: 2-Methyl-4H-3,1-benzoxazin-4-one

동의어(영문):: NSC 10119;NSC 521353;ACETANTHRANIL;AURORA KA-3785;Acetylanthranyl;ACETYL ANTHRANIL;TIMTEC-BB SBB000135;2-METHYL-3,1-BENZOXAZA-4-ONE;2-methyl-3,1-benzoxazin-4-one;2-methyl-4h-1-benzoxazin-4-one

CBNumber:: CB3163296

분자식:: C9H7NO2

포뮬러 무게:: 161.16

MOL 파일:: 525-76-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 125

2-Methyl-4H-3,1-benzoxazin-4-one 속성

녹는점: 79-82 °C(lit.)

끓는 점: 144-145 °C(Press: 12 Torr)

밀도: 1.25±0.1 g/cm3(Predicted)

저장 조건: under inert gas (nitrogen or Argon) at 2-8°C

산도 계수 (pKa): 2.84±0.20(Predicted)

InChI: InChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3

InChIKey: WMQSKECCMQRJRX-UHFFFAOYSA-N

SMILES: N1C2=CC=CC=C2C(=O)OC=1C

EPA: 4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
위험 등급	IRRITANT

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P271	옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

2-Methyl-4H-3,1-benzoxazin-4-one C화학적 특성, 용도, 생산

용도

2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038

Synthesis

In 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.
2-METHYL-3,1-BENZOXAZA-4-ONE

2-Methyl-4H-3,1-benzoxazin-4-one 준비 용품 및 원자재

원자재

2'-IODOACETANILIDE N-(2-ACETYL-PHENYL)-ACETAMIDE 2-Azidobenzoic acid PHENYL FORMATE carbon monoxide 아세틸 염화물 N-Acetylanthranilic acid 안스라닐산메틸 2-Iodoaniline 안트라닐산

준비 용품

1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER METHAQUALONE

2-Methyl-4H-3,1-benzoxazin-4-one 공급 업체

글로벌( 125)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Marvel pharm limited	+8613302302478	sales@marvelpharm.com	China	22	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

2-Methyl-4H-3,1-benzoxazin-4-one 관련 검색:

2-Methyl-4H-3,1-benzoxazin-4-one BENTRANIL AURORA 18390 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one AURORA 5332 2-(3-METHOXYPHENYL)-4H-3,1-BENZOXAZIN-4-ONE 2,6-dimethyl-4H-3,1-benzoxazin-4-one 2-(2-METHYLPHENYL)-4H-3,1-BENZOXAZIN-4-ONE 2-(4-FLUOROPHENYL)-4H-3,1-BENZOXAZIN-4-ONE 2-(o-Chlorophenyl)-4H-3,1-benzoxazin-4-one 2-(TRICHLOROMETHYL)-4H-3,1-BENZOXAZIN-4-ONE 2-(4-CHLOROPHENYL)-6-METHYL-4H-3,1-BENZOXAZIN-4-ONE AURORA 18389 2-(2-CHLOROPHENYL)-6-METHYL-4H-3,1-BENZOXAZIN-4-ONE 2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one 2-(CHLOROMETHYL)-4H-3,1-BENZOXAZIN-4-ONE AURORA KA-4769 2-(2,6-DICHLORO-4-PYRIDYL)-5-FLUORO-4H-3,1-BENZOXAZIN-4-ONE