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リオチロニンナトリウム

リオチロニンナトリウム 化学構造式
55-06-1
CAS番号.
55-06-1
化学名:
リオチロニンナトリウム
别名:
3,3',5-トリヨード-L-チロニン ナトリウム;シトミン;チロナミン;リオチロニンナトリウム;3,3',5-トリヨード-L-チロニンナトリウム;トリオチロン;シノメル;シトビン;シトメル;(S)-2-アミノ-3-[4-(4-ヒドロキシ-3-ヨードフェノキシ)-3,5-ジヨードフェニル]プロパン酸ナトリウム;トリヨードチロニンナトリウム;O-(4-ヒドロキシ-3-ヨードフェニル)-3,5-ジヨード-L-チロシンナトリウム;3-[4-(4-ヒドロキシ-3-ヨードフェノキシ)-3,5-ジヨードフェニル]アラニンナトリウム;3-[4-(4-ヒドロキシ-3-ヨードフェノキシ)-3,5-ジヨードフェニル]-L-アラニンナトリウム;テルトロキシン;3,3′,5-トリヨード-L-チロニンナトリウム;3,3′,5-トリヨード-L-チロニン ナトリウム塩;リオチロニンナトリウム (JP17);3,3,5-トリヨード-L-チロニンナトリウム
英語化学名:
Liothyronine sodium
英語别名:
Ibiot;Cyomel;T3, NA;Cytobin;Cynomel;Cytomine;Triostat;Sodium T3;Tertroxin;T3 Sodium
CBNumber:
CB3195390
化学式:
C15H11I3NNaO4
分子量:
672.96
MOL File:
55-06-1.mol

リオチロニンナトリウム 物理性質

融点 :
205 °C (dec.)(lit.)
比旋光度 :
20 º (c=2,alcohol/1.2N HCl)
RTECS 番号:
YP2836500
貯蔵温度 :
-20°C
溶解性:
4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
外見 :
powder
色:
White to Pale Brown
水溶解度 :
Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.
Sensitive :
Light Sensitive
Merck :
5510
BRN :
8179867
CAS データベース:
55-06-1(CAS DataBase Reference)
EPAの化学物質情報:
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (55-06-1)

安全性情報

主な危険性  Xn
Rフレーズ  20/21/22
Sフレーズ  22-24/25-36
WGK Germany  3
3-8-10
HSコード  29379000

リオチロニンナトリウム 価格 もっと(8)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan T2752 3,3′,5-トリヨード-L-チロニン ナトリウム塩 ≥95% (HPLC)
3,3′,5-Triiodo-L-thyronine sodium salt ≥95% (HPLC)
55-06-1 250mg ¥17100 2018-12-25 購入
Sigma-Aldrich Japan T2752 3,3′,5-トリヨード-L-チロニン ナトリウム塩 ≥95% (HPLC)
3,3′,5-Triiodo-L-thyronine sodium salt ≥95% (HPLC)
55-06-1 100mg ¥10400 2018-12-25 購入
Sigma-Aldrich Japan T6397 3,3′,5-トリヨード-L-チロニン ナトリウム塩 powder, BioReagent, suitable for cell culture
3,3′,5-Triiodo-L-thyronine sodium salt powder, BioReagent, suitable for cell culture
55-06-1 100mg ¥11100 2021-03-23 購入
Sigma-Aldrich Japan T6397 3,3′,5-トリヨード-L-チロニン ナトリウム塩 powder, BioReagent, suitable for cell culture
3,3′,5-Triiodo-L-thyronine sodium salt powder, BioReagent, suitable for cell culture
55-06-1 250mg ¥23800 2021-03-23 購入
Sigma-Aldrich Japan T6397 3,3′,5-トリヨード-L-チロニン ナトリウム塩 powder, BioReagent, suitable for cell culture
3,3′,5-Triiodo-L-thyronine sodium salt powder, BioReagent, suitable for cell culture
55-06-1 1g ¥63600 2021-03-23 購入

リオチロニンナトリウム 化学特性,用途語,生産方法

解説

O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt.C15H11I3NO4Na(672.98).3,5-ジヨード-L-チロニンのヨウ素化で得られる.リオチロニン(分解点236 ℃)のナトリウム塩.[α]D+18~+22°(エタノール).水に可溶.甲状腺腫,甲状腺機能低下症治療薬として使用される.チロキシンより速効性で2~5倍の効力がある.[CAS 55-06-1]"
森北出版「化学辞典(第2版)

効能

甲状腺ホルモン補充薬

商品名

チロナミン (武田薬品工業)

化学的特性

white to beige powder

Originator

Cytomel,SKF,US,1956

使用

L-3,3',5-Triiodothyronine, Sodium Salt is shown to stimulate respiratory activity at the mitochondrial level. T3 is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression.

使用

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

使用

cytochrome P450 inhibitor, Ca antagonist, anesthetic (local)

定義

ChEBI: The sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma.

適応症

Liothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3 alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.

Manufacturing Process

The 3,5-diiodo compound used as a starting material is a known material and may be prepared by the method in British Patents 643,089 and 671,070 and in the Journal of the Chemical Society, London, 1949, page 3424.
Synthesis: L-diiodo thyronine (1.05 g) is dissolved in ammonia (specific gravity 0.880) (40 ml) and methanol (40 ml) and iodinated slowly with shaking with N-iodine in KI solution at room temperature. After iodination,most of the ammonia and methanol are removed by evaporation under diminished pressure, water is added to the original volume, the solution is heated to 60°C and brought to pH 4 with hydrochloric acid. A crystalline precipitate is obtained which after cooling to room temperature is collected and washed with water. At this stage, the crude triiodo thyronine is contaminated with thyroxine and a little unchanged diiodo thyronine.
Purification: The crude precipitate is dissolved in boiling 2N HCl (300 ml) and filtered from the relatively insoluble thyroxine hydrochloride. The hot filtrate is brought to pH 4 with 5N NaOH and triiodo thyronine again separates; after chilling at 0° to 4°C it is collected, washed with water and dried. The yield of triiodo thyronine is 70 to 75% of the theoretical. This triiodo thyronine still contains some thyroxine (about 10%).
The final purification consists of chromatographic separation of thyroxine and triiodo thyronine on a kieselguhr column using 20% chloroform in n-butanol equilibrated with 0.5N NaOH as the developing solvent. 80 to 100 mg triiodo thyronine is purified during each run on a 50 g kieselguhr column. Pure Ltriiodo thyronine has MP 236° to 237°C (dec.) and [α]D29.5° = +21.5 in a 4.75% solution in a mixture of 1 part of N HCl and 2 parts of ethanol. Liothyronine is commonly used as the sodium salt.

brand name

Thyroid hormone Cytomel (King); Triostat (Jones).

Therapeutic Function

Thyroid hormone

一般的な説明

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Veterinary Drugs and Treatments

Because of its shorter duration of action, liothyronine is generally not considered the drug of first choice in treating hypothyroidism. Infrequently, animals not responding to levothyroxine may respond to liothyronine.

リオチロニンナトリウム 上流と下流の製品情報

原材料

準備製品


リオチロニンナトリウム 生産企業

Global( 238)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Suzhou Ryan Pharmachem Technology Co.,Ltd.
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Wuhan Demeikai Biotechnology Co., Ltd
+8618942921723
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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55-06-1(リオチロニンナトリウム)キーワード:


  • 55-06-1
  • LIOTHYRONINESODIUM,USP
  • 3,3',5-Triiodothyronine sodium salt
  • 3,5,3'-Triiodo-L-thyronine monosodium salt
  • Alanine, 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, monosodium salt, L- (8CI)
  • Basoprocin
  • Cynomel
  • Cyomel
  • Cytobin
  • Cytomel sodium
  • Cytomine
  • Ibiothyron
  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (9CI)
  • Sodium 3,3',5-triiodo-L-thyronine
  • Sodium 3,5,3'-triiodothyronine
  • Sodium L-3,3',5-triiodothyronine
  • Sodium liothyronine
  • Sodium L-triiodothyronine
  • Sodium T3
  • Sodium triiodo-L-thyronine
  • Sodium triiodothyronine
  • Tertroxin
  • Triiodothyronine sodium salt
  • Triostat
  • llothyronine sodium
  • 3,3,5-TRIIODO-L-THYRONINE SODIUM SALT 98+%
  • 3,3,5-TRIIODO-L -THYRONINE 95-98% SODIUM SALT CRYSTALLINE CELL CULTURE REAGENT
  • 3,3′,5-Triiodo-L-thyronine sodium salt, >=99%
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM*GAMMA- IRRADIATED
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM
  • Liothyronine Sodium USP28
  • 3,3',5-トリヨード-L-チロニン ナトリウム
  • シトミン
  • チロナミン
  • リオチロニンナトリウム
  • 3,3',5-トリヨード-L-チロニンナトリウム
  • トリオチロン
  • シノメル
  • シトビン
  • シトメル
  • (S)-2-アミノ-3-[4-(4-ヒドロキシ-3-ヨードフェノキシ)-3,5-ジヨードフェニル]プロパン酸ナトリウム
  • トリヨードチロニンナトリウム
  • O-(4-ヒドロキシ-3-ヨードフェニル)-3,5-ジヨード-L-チロシンナトリウム
  • 3-[4-(4-ヒドロキシ-3-ヨードフェノキシ)-3,5-ジヨードフェニル]アラニンナトリウム
  • 3-[4-(4-ヒドロキシ-3-ヨードフェノキシ)-3,5-ジヨードフェニル]-L-アラニンナトリウム
  • テルトロキシン
  • 3,3′,5-トリヨード-L-チロニンナトリウム
  • 3,3′,5-トリヨード-L-チロニン ナトリウム塩
  • リオチロニンナトリウム (JP17)
  • 3,3,5-トリヨード-L-チロニンナトリウム
  • 甲状腺ホルモン
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