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イミド尿素

イミド尿素 化学構造式
39236-46-9
CAS番号.
39236-46-9
化学名:
イミド尿素
别名:
バイオピュア100;ジェルマール115;N,N''-メチレンビス[N'-[3-(ヒドロキシメチル)-2,5-ジオキソ-4-イミダゾリジニル]尿素];イミダゾリジニル尿素;N,N''-メチレンビス[N'-(3-ヒドロキシメチル-2,5-ジオキソイミダゾリジン-4-イル)尿素];イミド尿素;N,N'-メチレンビス[N'-(3-ヒドロキシメチル-2,5-ジオキソ-4-イミダゾリジニル)尿素];イミダゾリジニルウレア;イミダゾリジニル尿素, 100 µg/mL in MeOH
英語化学名:
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
英語别名:
IMIDUREA;Sept 115;germall115;Tristat 1U;Biopure 100;Imidurea NF;Euxyl K 200;Unicide U-13;Imidurea (200 mg);Imidazolidnyl UREA
CBNumber:
CB3426267
化学式:
C11H16N8O8
分子量:
388.29
MOL File:
39236-46-9.mol

イミド尿素 物理性質

融点 :
141-143℃
沸点 :
514.04°C (rough estimate)
比重(密度) :
1.4245 (rough estimate)
屈折率 :
1.6910 (estimate)
貯蔵温度 :
2-8°C
溶解性:
Soluble in water and in glycerol, but insoluble in almost all organic solvents.
酸解離定数(Pka):
7.41±0.10(Predicted)
外見 :
Liquid
色:
Clear
水溶解度 :
soluble
Merck :
14,4916
安定性::
Stable.
InChIKey:
ZCTXEAQXZGPWFG-UHFFFAOYSA-N
CAS データベース:
39236-46-9(CAS DataBase Reference)
EPAの化学物質情報:
Imidurea (39236-46-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  36
Sフレーズ  26-36
WGK Germany  2
RTECS 番号 YT7365000
TSCA  Yes
HSコード  29332990
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。

イミド尿素 価格 もっと(21)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-120N イミダゾリジニル尿素
Imidazolidinyl urea
39236-46-9 100mg ¥3700 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-120S イミダゾリジニル尿素
Imidazolidinyl urea, 100 ug/mL in MeOH
39236-46-9 1mL ¥3700 2018-12-26 購入
東京化成工業 I0665 イミダゾリジニル尿素 >90.0%(N)
Imidazolidinyl Urea >90.0%(N)
39236-46-9 25g ¥3800 2018-12-04 購入
東京化成工業 I0665 イミダゾリジニル尿素 >90.0%(N)
Imidazolidinyl Urea >90.0%(N)
39236-46-9 250g ¥15600 2018-12-04 購入
関東化学株式会社(KANTO) 26870-1A イミド尿素 26%~28%(as N)
Imidurea 26%~28%(as N)
39236-46-9 100g ¥13800 2018-12-13 購入

イミド尿素 化学特性,用途語,生産方法

定義

本品は、次の化学式で表される複素環置換尿素である。

化粧品の成分用途

防腐剤

効能

抗菌薬

化学的特性

Imidurea is a white, free-flowing odorless powder.

化学的特性

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is solid with a mild odour

使用

Antimicrobial

使用

Antimicrobial preservative in cosmetics and topical pharmaceutical preparations.

使用

imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.

調製方法

Imidurea is produced by the condensation of allantoin with formaldehyde.

応用例(製薬)

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.

接触アレルゲン

Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.

安全性

Imidurea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics. Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg

貯蔵

Imidurea is hygroscopic and should be stored in a well-closed container in a cool, dry place.

不和合性

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (topical preparations). Accepted for use in cosmetics in Europe and the USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

イミド尿素 上流と下流の製品情報

原材料

準備製品


イミド尿素 生産企業

Global( 181)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21806 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Speranza Chemical Co., Ltd.
+8618688942810
+86-755-33122716 sophieliu@speranzachem.com CHINA 292 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1892 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 585 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30053 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8722 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20114 58

39236-46-9(イミド尿素)キーワード:


  • 39236-46-9
  • LABOTEST-BB LT00772046
  • IMIDAZOLIDINYL UREA
  • IMIDUREA
  • 1,1-METHYLENEBIS[3-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
  • N,N''-METHYLENEBIS[N'-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
  • N,N''-METHYLENEBIS[N-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
  • 1-imidazolidinylurea
  • germall115
  • Imidurea (200 mg)
  • IMidazilydinyl urea (IMU)
  • N,N'-Methylenebis[N'-(3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl)urea] Imidurea
  • 1,1'-Methylenebis(3-(3-(hydroxyMethyl)-2,5-dioxoiMidazolidin-4-yl)urea)
  • Imidazolidnyl UREA
  • n,n-methylenebis n'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
  • methanebis(n,n’-(5-ureido-2,4-diketotetrahydroimidazole)-n,n-dimethylol)
  • n,n’’-methylenebis(n’-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-ure
  • n,n’’-methylenebis[n’-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-ure
  • Biopure 100
  • Imidurea NF
  • Sept 115
  • Tristat 1U
  • Unicide U-13
  • N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
  • N.N''-Methylenebis-{N'-(3-hydroxymethyl)-2,5-dioxo-4-imidazolenyl-urea}
  • Imidurea, 26-28% nitrogen
  • Urea, N,N-methylenebisN-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-
  • Euxyl K 200
  • Urea, N,N''-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)
  • Imidazolidiny Urea
  • バイオピュア100
  • ジェルマール115
  • N,N''-メチレンビス[N'-[3-(ヒドロキシメチル)-2,5-ジオキソ-4-イミダゾリジニル]尿素]
  • イミダゾリジニル尿素
  • N,N''-メチレンビス[N'-(3-ヒドロキシメチル-2,5-ジオキソイミダゾリジン-4-イル)尿素]
  • イミド尿素
  • N,N'-メチレンビス[N'-(3-ヒドロキシメチル-2,5-ジオキソ-4-イミダゾリジニル)尿素]
  • イミダゾリジニルウレア
  • イミダゾリジニル尿素, 100 µg/mL in MeOH
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