ビス(N-フェニルカルバミド酸)3-ピペリジノ-1,2-プロパンジイル 化学特性,用途語,生産方法
Originator
Diothane Hydrochloride,HMR
Manufacturing Process
15.0 g phenylisocyanate in 100 ml of anhydrous ether are added to 10 g of N-
(1,2-dihydroxypropyl)-piperidine (prepared from glycide and piperidine) and
the solution boiled for two hours, after which it is cooled and saturated with
dry hydrogen chloride gas. The ether layer is then decanted off and the
remaining insoluble product is dissolved in a hot mixture of acetone and ethyl
acetate which on cooling precipitates white crystals of the hydrochloride of the
ester of 1,2-propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate); MP 197°-
198°C. A base form may be prepared by adding an equivalent of triethyl
amine.
Therapeutic Function
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate)
(ester), hydrochloride
ビス(N-フェニルカルバミド酸)3-ピペリジノ-1,2-プロパンジイル 上流と下流の製品情報
原材料
準備製品