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プラゾシン

プラゾシン 化学構造式
19216-56-9
CAS番号.
19216-56-9
化学名:
プラゾシン
别名:
2-[4-(2-フラニルカルボニル)ピペラジノ]-6,7-ジメトキシキナゾリン-4-アミン;1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-(フラン-2-イルカルボニル)ピペラジン;(2-フラニル)[4-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)ピペラジン-1-イル]ケトン;フラゾシン;プラゾシン;1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-(2-フロイル)ピペラジン;1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-(2-フラニルカルボニル)ピペラジン;1-(4-アミノ-6,7-ジメトキシ-2-キナゾリニル)-4-(2-フラニルカルボニル)ピペラジン;2-フリル4-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-1-ピペラジニルケトン;2-[4-(2-フロイル)ピペラジン-1-イル]-6,7-ジメトキシキナゾリン-4-アミン;2-[4-(2-フロイル)ピペラジノ]-6,7-ジメトキシキナゾリン-4-アミン;1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-[(フラン-2-イル)カルボニル]ピペラジン
英語化学名:
Prazosin
英語别名:
pressin;PRAZOSIN;furazosin;minipress;AKOS B020009;PrazosinBase;Terazosin-010;ART-CHEM-BB B020009;Terazosin Impurity15;Terazosin EP Impurity K
CBNumber:
CB8120869
化学式:
C19H21N5O4
分子量:
383.4
MOL File:
19216-56-9.mol

プラゾシン 物理性質

融点 :
278-280°C
沸点 :
510.33°C (rough estimate)
比重(密度) :
1.3275 (rough estimate)
屈折率 :
1.7600 (estimate)
酸解離定数(Pka):
pKa 6.54(50% EtOH) (Uncertain)
水溶解度 :
3.2mg/L(22.5 ºC)

安全性情報

プラゾシン 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC242509
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone hydrochloride salt
19216-56-9 250mg ¥75900 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MAS099656
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone
19216-56-9 500mg ¥330000 2018-12-26 購入

プラゾシン 化学特性,用途語,生産方法

効能

血圧降下薬, 血管拡張薬, α1アドレナリン受容体拮抗薬

使用

Antihypertensive.

定義

ChEBI: A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

brand name

Minipress (Pfizer).

臨床応用

Prazosin is effective in reducing all grades of hypertension. The drug can be administered alone in mild and (in some instances) moderate hypertension.When the hypertension is moderate or severe, prazosin generally is given in combination with a thiazide diuretic and a -blocker. The antihypertensive actions of prazosin are considerably potentiated by coadministration of thiazides or other types of antihypertensive drugs.
Prazosin may be particularly useful when patients cannot tolerate other classes of antihypertensive drugs or when blood pressure is not well controlled by other drugs. Since prazosin does not significantly influence blood uric acid or glucose levels, it can be used in hypertensive patients whose condition is complicated by diabetes mellitus or gout. Prazosin and other -antagonists find use in the management of benign prostatic obstruction, especially in patients who are not candidates for surgery. Blockade of -adrenoceptors in the base of the bladder and in the prostate apparently reduces the symptoms of obstruction and the urinary urgency that occurs at night.

副作用

Although less of a problem than with phenoxybenzamine or phentolamine, symptoms of postural hypotension, such as dizziness and light-headedness, are the most commonly reported side effects associated with prazosin therapy. These effects occur most frequently during initial treatment and when the dosage is sharply increased. Postural hypotension seems to be more pronounced during Na deficiency, as may occur in patients on a low-salt diet or being treated with diuretics, - blockers, or both.

Veterinary Drugs and Treatments

Prazosin is less well studied in dogs than hydralazine, and its capsule dosage form makes it less convenient for dosing. Prazosin, however, appears to have fewer problems with causing tachycardia, and its venous dilation effects may be an advantage over hydralazine when preload reduction is desired. It could be considered for therapy for the adjunctive treatment of CHF, particularly when secondary to mitral or aortic valve insufficiency when hydralazine is ineffective or not tolerated. Prazosin may also be used for the treatment of systemic hypertension or pulmonary hypertension in dogs.

プラゾシン 上流と下流の製品情報

原材料

準備製品


プラゾシン 生産企業

Global( 73)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20114 58
Henan tianfu chemical co. LTD
0371-55170695
info@hnbon.com CHINA 20537 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47484 58
career henan chemical co
0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 28298 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 127809 58
Chengdu Saint - Kay Biotechnology Co., Ltd. 15882256948
676046971@qq.com China 5066 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76
BePharm Ltd 4001-647-117
021-61629029 product@bidepharmatech.com China 24689 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70

19216-56-9(プラゾシン)キーワード:


  • 19216-56-9
  • [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone
  • Terazosin Impurity15
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-piperazin
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine.
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-piperazin
  • (4-(4-AMino-6,7-diMethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)Methanone hydrochloride salt
  • Terazosin EP Impurity K
  • Terazosin-010
  • 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
  • 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-quinazolin
  • furazosin
  • PRAZOSIN
  • pressin
  • PIPERAZINE, 1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)-
  • minipress
  • AKOS B020009
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine
  • ART-CHEM-BB B020009
  • PrazosinBase
  • Prazosin Hcl 19237-84-4 / Base
  • (2-Furanyl)[4-(4-amino-6,7-dimethoxyquinazoline-2-yl)piperazine-1-yl] ketone
  • 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(furan-2-ylcarbonyl)piperazine
  • 2-[4-(2-Furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
  • [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone
  • [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone
  • [4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-furan-2-yl-methanone
  • 1-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hidrochloride
  • 2-[4-(2-フラニルカルボニル)ピペラジノ]-6,7-ジメトキシキナゾリン-4-アミン
  • 1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-(フラン-2-イルカルボニル)ピペラジン
  • (2-フラニル)[4-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)ピペラジン-1-イル]ケトン
  • フラゾシン
  • プラゾシン
  • 1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-(2-フロイル)ピペラジン
  • 1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-(2-フラニルカルボニル)ピペラジン
  • 1-(4-アミノ-6,7-ジメトキシ-2-キナゾリニル)-4-(2-フラニルカルボニル)ピペラジン
  • 2-フリル4-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-1-ピペラジニルケトン
  • 2-[4-(2-フロイル)ピペラジン-1-イル]-6,7-ジメトキシキナゾリン-4-アミン
  • 2-[4-(2-フロイル)ピペラジノ]-6,7-ジメトキシキナゾリン-4-アミン
  • 1-(4-アミノ-6,7-ジメトキシキナゾリン-2-イル)-4-[(フラン-2-イル)カルボニル]ピペラジン
  • αアドレナリン遮断薬
  • 降圧薬
  • 泌尿器作用薬
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