メフロキン塩酸塩
メフロキン塩酸塩 物理性質
- 融点 :
- 250-254?C
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO: 38 mg/mL、可溶
- 外見 :
- 個体
- 色:
- 白い
- 極大吸収波長 (λmax):
- 222nm(Acidic H2O)(lit.)
- Merck :
- 14,5801
- BCS Class:
- 4/2
- 安定性：:
- 温度に敏感
- InChI:
- InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
- InChIKey:
- WESWYMRNZNDGBX-YLCXCWDSSA-N
- SMILES:
- C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
- CAS データベース:
- 51773-92-3(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
Xn |
|
|
| Rフレーズ |
22 |
|
|
| RIDADR |
UN 3077 9 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番号 |
VC0308000 |
|
|
| HSコード |
2933399090 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOPC404546 |
(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride |
51773-92-3 |
1g |
￥37000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOPC404546 |
(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride |
51773-92-3 |
5g |
￥139700 |
2024-03-01 |
購入 |
|
東京化成工業
|
M2313 |
メフロキン塩酸塩 >98.0%(HPLC)
Mefloquine Hydrochloride
>98.0%(HPLC) |
51773-92-3 |
1g |
￥14300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
M0253000 |
メフロキン 塩酸塩 European Pharmacopoeia (EP) Reference Standard
Mefloquine hydrochloride European Pharmacopoeia (EP) Reference Standard |
51773-92-3 |
m0253000 |
￥19400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1379059 |
メフロキン 塩酸塩 United States Pharmacopeia (USP) Reference Standard
Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard |
51773-92-3 |
100mg |
￥60800 |
2024-03-01 |
購入 |
メフロキン塩酸塩 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
抗マラリア薬
商品名
メファキン (久光製薬)
説明
Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination
with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria.
Administered once weekly, the combination is effective against pathogens
resistant to other agents.
化学的特性
White Solid
使用
Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.
一般的な説明
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
臨床応用
The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.
メフロキン塩酸塩 上流と下流の製品情報
原材料
準備製品
メフロキン塩酸塩 生産企業
Global( 248)Suppliers
51773-92-3(メフロキン塩酸塩)キーワード:
- 51773-92-3
- 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-4-quinolinemethanomonohydroch
- dl-erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol
- s*)-(r(+-)-lorid
- Mefloquin hydrochloride
- wr14249
- (αS)-rel-α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, hydrochloride (1:1)
- Mefloquine hydrochloride, >=99%
- (R)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-[(2S)-2-piperidyl]methanol hydrochloride
- wr142490
- Mefloquine Hydrochloride, USP
- (R)-[2,8-bis(trifluoroMethyl)quinolin-4-yl](2R)-piperidin-2-ylMethanol
- (S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol hydrochloride
- MEFLOQUINE HCL
- MEFLOQUINE HYDROCHLORIDE
- (AS)-REL-A-(2R)-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOL MONOHYDROCHLORIDE
- (2r)-(+/-)-alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
- (2,8-BIS-TRIFLUOROMETHYL-QUINOLIN-4-YL)-PIPERIDIN-2-YL-METHANOL HYDROCHLORIDE(R*,S*)
- (R*,S*)-(±)-alpha-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride
- MEFLOQUINE HYDROCHLORIDE EP(CRM STANDARD)
- (R*,S*)-(+-)-a-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride
- 4-Quinolinemethanol, 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-, monohydrochloride, (R*,S*)-, (+-)
- DL-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride
- Loriam
- (R*,S*)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol hydrochloride
- Ro 21-5998/001
- Mefloquine Hydrochloride (100 mg)
- (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride
- (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride
- (R)-[2,8-bis(trifluoromethyl)-4-quinolinyl][(2S)-2-piperidinyl]methanol hydrochloride
- MefloquineHydrochloride>
- メフロキン塩酸塩
- 塩酸メフロキン
- rac-(R*)-α-[(2S*)-2-ピペリジル]-2,8-ビス(トリフルオロメチル)-4-キノリンメタノール/塩酸,(1:1)
- メフロキン 塩酸塩
- メフロキン塩酸塩 (JP17)
- 抗マラリア薬