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メフロキン塩酸塩

メフロキン塩酸塩 化学構造式
51773-92-3
CAS番号.
51773-92-3
化学名:
メフロキン塩酸塩
别名:
メフロキン塩酸塩;塩酸メフロキン;rac-(R*)-α-[(2S*)-2-ピペリジル]-2,8-ビス(トリフルオロメチル)-4-キノリンメタノール/塩酸,(1:1);メフロキン 塩酸塩;メフロキン塩酸塩 (JP17)
英語化学名:
Mefloquine hydrochloride
英語别名:
Loriam;wr14249;wr142490;MEFLOQUINE HCL;Ro 21-5998/001;s*)-(r(+-)-lorid;Mefloquin hydrochloride;MEFLOQUINE HYDROCHLORIDE;Mefloquine Hydrochloride, USP;Mefloquine hydrochloride, >=99%
CBNumber:
CB6252498
化学式:
C17H17ClF6N2O
分子量:
414.77
MOL File:
51773-92-3.mol

メフロキン塩酸塩 物理性質

融点 :
250-254?C
貯蔵温度 :
Refrigerator
溶解性:
DMSO: 38 mg/mL, soluble
外見 :
solid
色:
white
極大吸収波長 (λmax):
222nm(Acidic H2O)(lit.)
Merck :
14,5801
InChIKey:
WESWYMRNZNDGBX-YLCXCWDSSA-N
CAS データベース:
51773-92-3(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS 番号 VC0308000
HSコード  2933399090
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
注意書き

メフロキン塩酸塩 価格 もっと(19)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01APOPC404546
(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride
51773-92-3 1g ¥71500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01APOPC404546
(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride
51773-92-3 5g ¥198000 2018-12-26 購入
東京化成工業 M2313 メフロキン塩酸塩 >98.0%(HPLC)
Mefloquine Hydrochloride >98.0%(HPLC)
51773-92-3 1g ¥13900 2018-12-04 購入
Sigma-Aldrich Japan M0253000 メフロキン 塩酸塩 European Pharmacopoeia (EP) Reference Standard
Mefloquine hydrochloride European Pharmacopoeia (EP) Reference Standard
51773-92-3 m0253000 ¥33600 2018-12-25 購入
Sigma-Aldrich Japan 1379059 メフロキン 塩酸塩 United States Pharmacopeia (USP) Reference Standard
Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard
51773-92-3 100mg ¥70900 2018-12-25 購入

メフロキン塩酸塩 化学特性,用途語,生産方法

効能

抗マラリア薬

商品名

メファキン (久光製薬)

説明

Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.

化学的特性

White Solid

Originator

Walter Reed (USA)

使用

Antimalarial;Heme polymerase inhibitor

使用

Quinoline methanol antimalarial agent.

brand name

FANSIMEF

臨床応用

The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.

メフロキン塩酸塩 上流と下流の製品情報

原材料

準備製品


メフロキン塩酸塩 生産企業

Global( 144)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21806 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24686 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30052 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20114 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35438 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63728 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47484 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58

51773-92-3(メフロキン塩酸塩)キーワード:


  • 51773-92-3
  • 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-4-quinolinemethanomonohydroch
  • dl-erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol
  • s*)-(r(+-)-lorid
  • Mefloquin hydrochloride
  • (αS)-rel-α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, hydrochloride (1:1)
  • Mefloquine hydrochloride, >=99%
  • (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride
  • (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride
  • (R)-[2,8-bis(trifluoromethyl)-4-quinolinyl][(2S)-2-piperidinyl]methanol hydrochloride
  • wr142490
  • MEFLOQUINE HCL
  • MEFLOQUINE HYDROCHLORIDE
  • (R)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-[(2S)-2-piperidyl]methanol hydrochloride
  • wr14249
  • (AS)-REL-A-(2R)-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOL MONOHYDROCHLORIDE
  • (2r)-(+/-)-alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
  • (2,8-BIS-TRIFLUOROMETHYL-QUINOLIN-4-YL)-PIPERIDIN-2-YL-METHANOL HYDROCHLORIDE(R*,S*)
  • (R*,S*)-(±)-alpha-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride
  • MEFLOQUINE HYDROCHLORIDE EP(CRM STANDARD)
  • (R*,S*)-(+-)-a-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride
  • 4-Quinolinemethanol, 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-, monohydrochloride, (R*,S*)-, (+-)
  • DL-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride
  • Loriam
  • (R*,S*)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol hydrochloride
  • Ro 21-5998/001
  • Mefloquine Hydrochloride (100 mg)
  • Mefloquine Hydrochloride, USP
  • (R)-[2,8-bis(trifluoroMethyl)quinolin-4-yl](2R)-piperidin-2-ylMethanol
  • (S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol hydrochloride
  • メフロキン塩酸塩
  • 塩酸メフロキン
  • rac-(R*)-α-[(2S*)-2-ピペリジル]-2,8-ビス(トリフルオロメチル)-4-キノリンメタノール/塩酸,(1:1)
  • メフロキン 塩酸塩
  • メフロキン塩酸塩 (JP17)
  • 抗マラリア薬
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