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ペチジン·塩酸塩

ペチジン·塩酸塩 化学構造式
50-13-5
CAS番号.
50-13-5
化学名:
ペチジン·塩酸塩
别名:
ペチジン塩酸塩;イソニペカイン塩酸塩;1-メチル-4-フェニル-4-ピペリジンカルボン酸エチル·塩酸塩;ペチジン·塩酸塩;ペチロルファン;オペリジン;ドラルガン;塩酸メペリジン;デメロール塩酸塩;メペリジン塩酸塩;ドルシン;ドリン;ドロサール;リドール;ドルコントラール;塩酸ペチジン;ペタンチン;ピリドサール;オピスタン;ドランチン
英語化学名:
MEPERIDINE HYDROCHLORIDE
英語别名:
s140;algil;dolin;lidol;wy554;dolaren;dolosal;endolat;mepadin;petidin
CBNumber:
CB0251343
化学式:
C15H22ClNO2
分子量:
283.79
MOL File:
50-13-5.mol

ペチジン·塩酸塩 物理性質

融点 :
186-189°
沸点 :
282°C (rough estimate)
比重(密度) :
1.0858 (rough estimate)
屈折率 :
1.5200 (estimate)
闪点 :
11 °C
貯蔵温度 :
2-8°C
溶解性:
Very soluble in water, freely soluble in alcohol.
CAS データベース:
50-13-5
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,F
Rフレーズ  25-39/23/24/25-23/24/25-11
Sフレーズ  26-36/37/39-45-36/37-16-7
RIDADR  1544
WGK Germany  3
RTECS 番号 NS5950000
国連危険物分類  6.1(b)
容器等級  III
HSコード  2933330000
毒性 LD50 orally in rats: 170 mg/kg (Barlow, Lewis)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
注意書き
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。

ペチジン·塩酸塩 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ペチジン·塩酸塩 化学特性,用途語,生産方法

効能

麻薬性鎮痛薬, 鎮痙薬, オピオイド受容体作動薬

商品名

ペチジン塩酸塩 (武田薬品工業)

化学的特性

White or almost white, crystalline powder.

Originator

Dolosal,Specia,France,1943

使用

Analgesic; sedative; anesthetic. Controlled substance (opiate).

定義

An addictive drug, use by prescription only.

Manufacturing Process

80 parts of finely pulverized sodium amide are added in portions each of about ? of the entire quantity, while stirring and cooling in a suitable manner, to a mixture of 756 parts of methyl-di(β-chloroethyl)-amine (prepared from di-ethanol-methylamine by means of thionyl chloride), 117 parts of benzyl cyanide and 600 parts of toluene. The reaction sets in at once at room temperature. The temperature is maintained between 30° and 40°C; when self-heating no longer occurs a further portion of the sodium amide is introduced. During the reaction heat is liberated and gaseous ammonia escapes.
The mixture is then slowly heated to the boiling point of toluene and kept boiling for one hour under reflux. After the mixture has been allowed to cool the sodium chloride which precipitates is separated by extraction with water. The solution of toluene is then extracted with dilute hydrochloric acid. From the hydrochloric acid extract the basic substance is separated in the form of an oil by means of caustic soda solution and is introduced into ether. The ethereal solution is dried with the aid of potassium carbonate and then distilled.
Under a pressure of 4.5 ml the 1-methyl-4-phenyl-piperidine-4-carboxylic acid nitrile passes over at a temperature of about 148°C in the form of a colorless oil; under a pressure of 6 ml it passes over at about 158°C. After having been allowed to cool the distillate solidifies completely to form a crystalline mass. Its solidification point is at 53°C; the yield amounts to about 135 parts, that is, about 2/3 of the theoretical yield. When recrystallized from isopropyl alcohol the hydrochloride of the nitrile forms colorless crystals, readily soluble in water and melting at 221° to 222°C.
The nitrile may best be saponified with methyl alcoholic potash while heating to 190° to 200°C with application of pressure. After the methyl alcohol has evaporated the salt is introduced into water and by the addition of dilute mineral acid until the alkaline reaction to phenolphthalein has just disappeared, the amphoteric 1-methyl-4-phenyl-piperidine-4-carboxylic acid is precipitated while hot in the form of a colorless, coarsely crystalline powder. When dried on the water bath the acid still contains 1 mol of crystal water which is lost only at a raised temperature. The acid melts at 299°C. Reaction with ethanol yields the ester melting at 30°C and subsequent reaction with HCl gives the hydrochloride melting at 187° to 188°C.

brand name

Demerol (Hospira); Demerol (Sanofi Aventis).

Therapeutic Function

Narcotic analgesic

臨床応用

Meperidine is a μ agonist with approximately one-tenth the potency of morphine after intramuscular dose. Meperidine produces the analgesia, respiratory depression, and euphoria caused by other μ opioid agonists, but it causes less constipation and does not inhibit cough. When given orally, meperidine has 40 to 60% bioavailability because of significant first-pass metabolism. Because of the limited bioavailability, it is one-third as potent after an oral dose compared to a parenteral dose.
Meperidine has received extensive use in obstetrics because of its rapid onset and short duration of action. When it is given intravenously in small (25-mg) doses during delivery, the respiratory depression in the newborn child is minimized. Meperidine is used as an analgesic in a variety of nonobstetric anesthetic procedures. Meperidine is extensively metabolized in the liver, with only 5% of the drug being excreted unchanged. Prolonged dosage of meperidine may cause an accumulation of the metabolite normeperidine. Normeperidine has only weak analgesic activity, but it causes CNS excitation and can initiate grand mal seizures. It is recommended that meperidine be discontinued in any patient who exhibits signs of CNS excitation.
Meperidine has a strong adverse reaction when given to patients receiving a monoamine oxidase inhibitor. This drug interaction has been seen recently in patients with Parkinson's disease taking the monoamine oxidase–selective inhibitor selegiline (Eldepryl).
The elimination half-life of meperidine is 3 to 4 hours, and it can double in patients with liver disease. Acidification of the urine will cause enhanced clearance of meperidine, but there is a lesser effect on the clearance of the toxic metabolite normeperidine.

安全性プロファイル

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic effects. Mutation data reported. An analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Veterinary Drugs and Treatments

Although no product is licensed in the United States for veterinary use, this agent has been used as an analgesic in several different species. It has been used as sedative/analgesic in small animals for both post-operative pain and for medical conditions such as acute pancreatitis and thermal burns, but usually other opiates are preferred as the drug has a short analgesic duration of activity and can cause significant histamine release. It is occasionally used in equine medicine in the treatment of colic and in other large animal species for pain control.

ペチジン·塩酸塩 上流と下流の製品情報

原材料

準備製品


ペチジン·塩酸塩 生産企業

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50-13-5(ペチジン·塩酸塩)キーワード:


  • 50-13-5
  • 1-METHYL-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
  • MEPERIDINE HYDROCHLORIDE
  • 1-methyl-4-carbethoxy-4-phenylpiperidinehydrochloride
  • 1-methyl-4-phenyl-4-carboethoxypiperidinehydrochloride
  • 1-methyl-4-phenylisonipecoticacidethylesterhydrochloride
  • 4-piperidinecarboxylicacid,1-methyl-4-phenyl-,ethylester,hydrochloride
  • algil
  • alodan(gerot)
  • antidurol
  • centralgin
  • chlorbicyclene
  • chlorbycyclen
  • demerolhydrochloride
  • dispadol
  • dolantal
  • dolantinhydrochloride
  • dolantol
  • dolaren
  • dolargan
  • dolcontral
  • dolin
  • doloneurine
  • dolopethin
  • dolosal
  • dolvanol
  • endolat
  • ethyl-1-methyl-4-phenylisonipecotatehydrochloride
  • ethyl1-methyl-4-phenylpiperidyl-4-carboxylatehydrochloride
  • isonipecainehydrochloride
  • isonipecoticacid,1-methyl-4-phenyl-,ethylester,hydrochloride
  • ペチジン塩酸塩
  • イソニペカイン塩酸塩
  • 1-メチル-4-フェニル-4-ピペリジンカルボン酸エチル·塩酸塩
  • ペチジン·塩酸塩
  • ペチロルファン
  • オペリジン
  • ドラルガン
  • 塩酸メペリジン
  • デメロール塩酸塩
  • メペリジン塩酸塩
  • ドルシン
  • ドリン
  • ドロサール
  • リドール
  • ドルコントラール
  • 塩酸ペチジン
  • ペタンチン
  • ピリドサール
  • オピスタン
  • ドランチン
  • ペチジン塩酸塩 (JP17)
  • 麻薬性鎮痛薬
  • 鎮痙薬
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