ブチリルクロリド 化学特性,用途語,生産方法
外観
無色~わずかにうすい黄色, 澄明の液体
溶解性
アセトンに極めて溶けやすく、水及びエタノールで分解する。
用途
アシル化剤、重合触媒、有機合成用中間体
使用上の注意
・腐食性及び不快臭がありますので、取扱う場合は、局所排気装置、保護眼鏡及び保護手袋を用いて下さい。・水分の吸収により分解しますので、使用後は直ちに栓又は封をして下さい。・加水分解によって発生するHClのため、容器の内圧が高くなることがありますので、開栓する時はよく冷却し、保護眼鏡及び保護手袋を用いて下さい。
化学的特性
Butyryl chloride is a colorless to light yellow liquid with a strong pungent odor. It undergoes vigorous hydrolysis with water; decomposes in water; soluble in almost aprotic organic solvents. It is used as an intermediate for organic synthesis for the preparation of pharmaceuticals, agrochemicals, dyes, cellulose esters, and peroxide compounds.
使用
Butyryl chloride is used as an intermediate for the synthesis of active pharmaceutical ingredients benzoyl peroxide, t-butyl perbenzoate, and benzophenone. It is also used as an acylation reagent. Further, it is used in the preparation of peroxides such as benzoyl peroxide, benzophenone and t-butyl perbenzoate. In addition to this, it is involved in the preparation of chromones and antiproliferative agents.
Butyryl chloride has been used to esterify wood meal dissolved in the ionic liquid, 1-butyl-3-methylimidazolium chloride.
一般的な説明
A clear colorless liquid with a sharp odor. Slightly denser than water. Flash point near 20°F. Severely irritates skin, eyes, and mucous membranes. Used to make other chemicals.
空気と水の反応
Highly flammable. Fumes in air. Decomposes exothermically in water to give corrosive hydrochloric acid.
反応プロフィール
Butyryl chloride slowly dissolves in water with decomposition and formation of a weakly acidic solution. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
健康ハザード
Extremely destructive to the mucous membranes, upper respiratory tract, eyes, and skin. Inhalation may cause death as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
火災危険
Special Hazards of Combustion Products: Emits toxic fumes of chlorine gas
純化方法
Check IR to see if there is a significant peak at 3000-3500 cm-1 (br) for OH. If OH is present then reflux with less than one mole equivalent of SOCl2 for 1hour and distil directly. The fraction boiling between 85-100o is then refractionated at atmospheric pressure. Keep all apparatus free from moisture and store the product in sealed glass ampoules under N2. LACHRYMATORY; handle in a good fume hood. [Hefferich & Schaeffer Org Synth Coll Vol I 147 1941, Beilstein 2 IV 803.]
ブチリルクロリド 上流と下流の製品情報
原材料
準備製品