(4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン

(4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン 価格 もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	T2580	トラポキシンA ≥98% (HPLC), from Helicoma ambiens Trapoxin A ≥98% (HPLC), from Helicoma ambiens	133155-89-2	1mg	￥47000	2024-03-01	購入
Sigma-Aldrich Japan	T2580	トラポキシンA ≥98% (HPLC), from Helicoma ambiens Trapoxin A ≥98% (HPLC), from Helicoma ambiens	133155-89-2	5mg	￥108000	2024-03-01	購入

(4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン 化学特性,用途語,生産方法

説明

Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC₅₀ = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml. It also halts the cell cycle at the G₂ phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A at a concentration of 50 ng/ml.

使用

Trapoxin A has been used:

• to study its effects on the inhibition of histone deacetylase 11 (HDAC11)
• to study its effects on the inhibition of HDAC3 in human cell lines
• to study its effects on the inhibition of HDAC6 in rat pyramidal neurons

定義

ChEBI: A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues.

(4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン 上流と下流の製品情報

原材料

準備製品

(4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
InvivoChem	13549236410	sales@invivochem.cn	China	6712	58

133155-89-2((4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン)キーワード:

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• 133155-89-2
• trapoxin A
• (4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone
• Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-]
• RF-1023A
• Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl)
• Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl]
• Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl]
• トラポキシンA
• (4aR,7S,10S,13S)-10,13-ジベンジル-7-[6-オキソ-6-[(S)-オキシラニル]ヘキシル]-1,2,3,4,9,10-ヘキサヒドロ-4aH-6,9,12,14a-テトラアザベンゾシクロドデセン-5,8,11,14(6H,7H,12H,13H)-テトラオン
• シクロ[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-オキシラニル]-2-オキソエチル]-L-Nle-]
• (3S,6S,9S,15aR)-6,9-ジベンジル-3-{6-[(2S)-オキシラン-2-イル]-6-オキソヘキシル}-テトラデカヒドロ-1H-ピリド[1,2-a]1,4,7,10-テトラアザシクロドデカン-1,4,7,10-テトラオン