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2-プロピル吉草酸

2-プロピル吉草酸 化学構造式
99-66-1
CAS番号.
99-66-1
化学名:
2-プロピル吉草酸
别名:
2-プロピル吉草酸;バルプロ酸;2-プロピルペンタン酸;エピリム;バルプロン酸;ジプロピル酢酸;デパキン;エルゲニル;2-プロパン-1-イルペンタン酸 (別名:バルプロ酸);2‐プロピルペンタン酸;バルプロ酸 溶液
英語化学名:
2-Propylpentanoic acid
英語别名:
VPA;44089;Epilim;Ergenyl;depakote;Mylproin;Valproic;Convulex;Depakene;Depakine
CBNumber:
CB7149528
化学式:
C8H16O2
分子量:
144.21
MOL File:
99-66-1.mol

2-プロピル吉草酸 物理性質

融点 :
-21.25°C (estimate)
沸点 :
220 °C(lit.)
比重(密度) :
0.92
蒸気圧:
0.01 hPa (20 °C)
屈折率 :
n20/D 1.425(lit.)
闪点 :
232 °F
貯蔵温度 :
2-8°C
溶解性:
H2O: slightly soluble
外見 :
Liquid
酸解離定数(Pka):
4.6(at 25℃)
色:
Clear colorless to pale yellow
爆発限界(explosive limit):
1%(V)
水溶解度 :
slightly soluble
Merck :
14,9913
BRN :
1750447
CAS データベース:
99-66-1(CAS DataBase Reference)
NISTの化学物質情報:
Valproic Acid(99-66-1)
EPAの化学物質情報:
Pentanoic acid, 2-propyl-(99-66-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,T,F
Rフレーズ  22-36/37/38-39/23/24/25-23/24/25-11-34-61
Sフレーズ  26-45-36/37-16-7-36/37/39-53
RIDADR  UN 1230 3/PG 2
WGK Germany  3
RTECS 番号 YV7875000
国連危険物分類  8
容器等級  III
HSコード  29159080
有毒物質データの 99-66-1(Hazardous Substances Data)
毒性 LD50 orally in rats: 670 mg/kg (Jenner)
消防法 危-4-3-III
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P309 暴露したとき、または気分が悪い時:
P310 ただちに医師に連絡すること。
P311 医師に連絡すること。

2-プロピル吉草酸 価格 もっと(21)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC386761 2-プロピルペンタン酸
2-PROPYLPENTANOIC ACID
99-66-1 10g ¥7300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01FLC386761 2-プロピルペンタン酸
2-PROPYLPENTANOIC ACID
99-66-1 25g ¥15200 2018-12-26 購入
東京化成工業 P0823 2-プロピル吉草酸 >99.0%(GC)(T)
2-Propylvaleric Acid >99.0%(GC)(T)
99-66-1 100mL ¥19500 2018-12-04 購入
東京化成工業 P0823 2-プロピル吉草酸 >99.0%(GC)(T)
2-Propylvaleric Acid >99.0%(GC)(T)
99-66-1 25mL ¥5900 2018-12-04 購入
関東化学株式会社(KANTO) 20833-1A 2‐プロピルペンタン酸 99%
2‐Propylpentanoic acid 99%
99-66-1 25g ¥8000 2018-12-13 購入

2-プロピル吉草酸 MSDS


Valproic acid

2-プロピル吉草酸 化学特性,用途語,生産方法

外観

無色~黄褐色, 澄明の液体

溶解性

エタノールに易溶, 水に難溶。水に難溶、有機溶媒に可溶。水に微溶。

用途

薬理研究用。

用途

医薬原料

効能

抗けいれん薬

化学的特性

Colorless Liquid

使用

Antiepileptic; increases levels of -aminobutyric acid(GABA) in the brain. Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

使用

Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.

使用

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures asso

定義

ChEBI: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

brand name

Depakene (Abbott);Valproine;Vederon.

生物学の機能

Although it is marketed as both valproic acid (Depakene) and as sodium valproate (Depakote), it is the valproate ion that is absorbed from the gastrointestinal tract and is the active form.
As with several other AEDs, it is difficult to ascribe a single mechanism of action to valproic acid.This compound has broad anticonvulsant activity, both in experimental studies and in the therapeutic management of human epilepsy.Valproic acid has been shown to block voltage-dependent sodium channels at therapeutically relevant concentrations. In several experimental studies, valproate caused an increase in brain GABA; the mechanism was unclear.There is evidence that valproate may also inhibit T-calcium channels and that this may be important in its mechanism of action in patients with absence epilepsy.

一般的な説明

VPA is an established AED with a simple chemical structurebut an unusually broad spectrum of action. It is generallywell tolerated, but its use is limited by two rare but significanttoxic side effects (hepatotoxicity and teratogenicity) thatcan be dose-dependent or idiosyncratic in nature.Thesedrawbacks are apparently shared by its equipotent activemetabolite, (E)-2-propyl-2-pentenoic acid (2-ene-VPA).
VPA is also an important inhibitor of the cytochrome P450isozymes, mainly of CYP2C9 and also of uridine diphosphate(UDP)-glucuronyl transferase and epoxide hydrolase.

一般的な説明

Clear colorless liquid.

空気と水の反応

Insoluble in water.

反応プロフィール

2-Propylpentanoic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 2-Propylpentanoic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. 2-Propylpentanoic acid is incompatible with bases, oxidizing agents and reducing agents. 2-Propylpentanoic acid is corrosive. .

火災危険

2-Propylpentanoic acid is combustible.

臨床応用

Valproic acid is well absorbed from the gastrointestinal tract and is highly bound (~90%) to plasma protein, and most of the compound is therefore retained within the vascular compartment.Valproate rapidly enters the brain from the circulation; the subsequent decline in brain concentration parallels that in plasma, indicating equilibration between brain and capillary blood. A large number of metabolites have been identified, but it is not known whether they play a role in the anticonvulsant effect of the parent drug. Valproic acid inhibits the metabolism of several drugs, including phenobarbital, primidone, carbamazepine, and phenytoin, leading to an increased blood level of these compounds. At high doses, valproic acid can inhibit its own metabolism. It can also displace phenytoin from binding sites on plasma proteins, with a resultant increase in unbound phenytoin and increased phenytoin toxicity. In this instance, the dosage of phenytoin should be adjusted as required. These examples reinforce the need to determine serum anticonvulsant levels in epileptic patients when polytherapy is employed.
Valproic acid has become a major AED against several seizure types. It is highly effective against absence seizures and myoclonic seizures. In addition, valproic acid can be used either alone or in combination with other drugs for the treatment of generalized tonic– clonic epilepsy and for partial seizures with complex symptoms.

副作用

The most serious adverse effect associated with valproic acid is fatal hepatic failure. Fatal hepatotoxicity is most likely to occur in children under age 2 years, especially in those with severe seizures who are given multiple anticonvulsant drug therapy. The hepatotoxicity is not dose related and is considered an idiosyncratic reaction; it can occur in individuals in other age groups, and therefore, valproic acid should not be administered to patients with hepatic disease or significant hepatic dysfunction or to those who are hypersensitive to it. Valproic acid administration has been linked to an increased incidence of neural tube defects in the fetus of mothers who received valproate during the first trimester of pregnancy. Patients taking valproate may develop clotting abnormalities.
Valproic acid causes hair loss in about 5% of patients, but this effect is reversible. Transient gastrointestinal effects are common, and some mild behavioral effects have been reported. Metabolic effects, including hyperglycemia, hyperglycinuria, and hyperammonemia, have been reported. An increase in body weight also has been noted. Valproic acid is not a CNS depressant, but its administration may lead to increased depression if it is used in combination with phenobarbital, primidone, benzodiazepines, or other CNS depressant agents.

2-プロピル吉草酸 上流と下流の製品情報

原材料

準備製品


2-プロピル吉草酸 生産企業

Global( 217)Suppliers
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99-66-1(2-プロピル吉草酸)キーワード:


  • 99-66-1
  • Propylvaleric acid
  • Valeric acid, 2-propyl-
  • Valericacid,2-propyl-
  • valproate
  • Valproesαure
  • valproicacid(INN)
  • DI-N-PROPYLACETIC ACID
  • DIPROPYLACETIC ACID
  • DIVALPROEX
  • 2,2-DI-N-PROPYLACETIC ACID
  • Dipropylacetic Acid Valproic Acid 2-Propylpentanoic Acid
  • Valproic Acid(Dipropylacetic acid)
  • 2-PROPYLVALERIC ACID FOR SYNTHESIS
  • VPA
  • (n-C3H7)2CHCOOH
  • 2 PP (base)
  • 2-n-Propylpentanoicacid
  • 2-n-Propylvalericacid
  • 2-Propylpentansαure
  • depakote
  • Di-n-propylessigsaure
  • dipropyl-aceticaci
  • Epilim
  • Ergenyl
  • Heptane-4-carboxylicacid
  • Kyselina 2-propylvalerova
  • Valproic acid USP/EP
  • Valproic acid for system suitability
  • Valproic acid solution
  • DI PROPYL ACETIC ACID (VALPROIC ACID)
  • 2-プロピル吉草酸
  • バルプロ酸
  • 2-プロピルペンタン酸
  • エピリム
  • バルプロン酸
  • ジプロピル酢酸
  • デパキン
  • エルゲニル
  • 2-プロパン-1-イルペンタン酸 (別名:バルプロ酸)
  • 2‐プロピルペンタン酸
  • バルプロ酸 溶液
  • 代謝産物
  • 抗痙攣薬
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