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くえん酸

くえん酸 化学構造式
77-92-9
CAS番号.
77-92-9
化学名:
くえん酸
别名:
くえん酸;β-ヒドロキシトリカルバリル酸;シトレッテン;2-ヒドロキシ-1,2,3-プロパントリカルボン酸;2-ヒドロキシプロパン-1,2,3-トリカルボン酸;アシレッテン;シトロ;枸櫞酸;3-カルボキシ-3-ヒドロキシペンタン-1,5-二酸;くえん酸,無水;くえん酸(無水);2W/V% くえん酸溶液;クエン酸 TESTED ACCORDING TO PH.EUR.,ANHYDROUS,GRIT;くえん酸〔無水〕;無水クエン酸;くえん酸、無水;無水クエン酸 (JP17)
英語化学名:
Citric acid
英語别名:
Citro;E 330;F 4020;Suby G;INS 330;nsc30279;CheMfill;C6H8O7H20;BETZ 0623;BETZ 6251
CBNumber:
CB9854361
化学式:
C6H8O7
分子量:
192.12
MOL File:
77-92-9.mol

くえん酸 物理性質

融点 :
153-159 °C(lit.)
沸点 :
248.08°C (rough estimate)
比重(密度) :
1.542
蒸気密度:
7.26 (vs air)
蒸気圧:
<0.1 hPa (20 °C)
屈折率 :
1.493~1.509
FEMA :
2306 | CITRIC ACID
闪点 :
100 °C
貯蔵温度 :
Store at RT.
溶解性:
H2O: 1 M at 20 °C, clear, colorless
酸解離定数(Pka):
3.14(at 20℃)
外見 :
grit
色:
White
臭い (Odor):
Odorless
PH:
1.0-2.0 (25℃, 1M in H2O)
爆発限界(explosive limit):
8%, 65°F
水溶解度 :
750 g/L (20 ºC)
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.20
λ: 280 nm Amax: 0.10
Sensitive :
Hygroscopic
JECFA Number:
218
Merck :
14,2326
BRN :
782061
安定性::
Stable. Incompatible with bases, strong oxidizing agents, reducing agents, metal nitrates.
InChIKey:
KRKNYBCHXYNGOX-UHFFFAOYSA-N
CAS データベース:
77-92-9(CAS DataBase Reference)
NISTの化学物質情報:
1,2,3-Propanetricarboxylic acid, 2-hydroxy-(77-92-9)
EPAの化学物質情報:
Citric acid (77-92-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi,C,T
Rフレーズ  41-36/37/38-36/38-37/38-34-36-35-61-60
Sフレーズ  26-39-37/39-24/25-36/37/39-45-36-53
RIDADR  UN 1789 8/PG 3
WGK Germany  1
RTECS 番号 GE7350000
9
TSCA  Yes
HSコード  2918 14 00
有毒物質データの 77-92-9(Hazardous Substances Data)
毒性 LD50 in mice, rats (mmol/kg): 5.0, 4.6 i.p. (Gruber, Halbeisen)
化審法 (2)-1318 届出不要化学物質
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H303 飲み込むと有害のおそれ 急性毒性、経口 5 P312
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。
P405 施錠して保管すること。

くえん酸 価格 もっと(66)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00003683 くえん酸
Citric Acid
77-92-9 100mg ¥19300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00003683 くえん酸
Citric Acid
77-92-9 250mg ¥32800 2018-12-26 購入
東京化成工業 C1949 くえん酸 >98.0%(T)
Citric Acid >98.0%(T)
77-92-9 500g ¥1900 2018-12-04 購入
関東化学株式会社(KANTO) 08309-00 くえん酸 >99.0%(T)
Citric acid >99.0%(T)
77-92-9 500g ¥1900 2018-12-13 購入
関東化学株式会社(KANTO) 22034-1A くえん酸(無水)
Citric acid, anhydrous
77-92-9 100g ¥5400 2018-12-13 購入

くえん酸 化学特性,用途語,生産方法

外観

白色~ほとんど白色, 結晶~結晶性粉末

定義

本品は、次の化学式で表される有機酸である。

溶解性

水に可溶。アルコールに可溶。水に極めて溶けやすく、エタノールに溶けやすく、ジエチルエーテルにやや溶けにくい。

用途

酸味料、清涼飲料水原料、抗酸化剤

用途

医薬品、食品等の原料。

化粧品の成分用途

pH調整剤、キレート剤、香料

効能

緩衝剤, 矯味・矯臭剤

確認試験

本品を105℃で2時間乾燥し,赤外吸収スペクトル 測定法〈2.25〉の臭化カリウム錠剤法により試験を行い,本 品のスペクトルと本品の参照スペクトルを比較するとき,両 者のスペクトルは同一波数のところに同様の強度の吸収を認 める.

定量法

本品約0.55gを精密に量り,水50mLに溶かし, 1mol/L水酸化ナトリウム液で滴定〈2.50〉する(指示薬:フェ ノールフタレイン試液2滴).

純度試験

(1) 溶状 本品2.0gを水に溶かして10mLとするとき,液 は澄明であり,その色は次の比較液(1),比較液(2)又は比較 液(3)より濃くない.
比較液(1):塩化コバルト(Ⅱ)の色の比較原液1.5mL及び塩 化鉄(Ⅲ)の色の比較原液6.0mLをとり,水を加えて 1000mLとする.
比較液(2):塩化コバルト(Ⅱ)の色の比較原液0.15mL,塩 化鉄(Ⅲ)の色の比較原液7.2mL及び硫酸銅(Ⅱ)の色の比 較原液0.15mLをとり,水を加えて1000mLとする.
比較液(3):塩化コバルト(Ⅱ)の色の比較原液2.5mL,塩化 鉄(Ⅲ)の色の比較原液6.0mL及び硫酸銅(Ⅱ)の色の比較 原液1.0mLをとり,水を加えて1000mLとする.
(2) 硫酸塩 本品2.0gを水に溶かして30mLとし,試料溶 液とする.別に硫酸カリウム0.181gを薄めたエタノール(3→ 10)に溶かし,正確に500mLとする.この液5mLを正確に量 り,薄めたエタノール(3→10)を加えて正確に100mLとする. この液4.5mLに塩化バリウム二水和物溶液(1→4)3mLを加え て振り混ぜ,1分間放置する.この液2.5mLに試料溶液 15mL及び酢酸(31)0.5mLを加えて5分間放置するとき,液の 混濁は次の比較液より濃くない.
比較液: 硫酸カリウム0.181gを水に溶かし,正確に 500mLとする.この液5mLを正確に量り,水を加えて 正確に100mLとする.この液を試料溶液の代わりに用 いて,同様に操作する.
(3) シュウ酸 本品0.80gを水4mLに溶かした液に塩酸 3mL及び亜鉛1gを加え,1分間煮沸する.2分間放置後,上 澄液をとり,これに塩酸フェニルヒドラジニウム溶液(1→100)0.25mLを加え,沸騰するまで加熱した後,急冷する.
この液に等容量の塩酸及びヘキサシアノ鉄(Ⅲ)酸カリウム溶 液(1→20)0.25mLを加えて振り混ぜた後,30分間放置すると き,液の色は同時に調製した次の比較液より濃くない.
比較液:シュウ酸二水和物溶液(1→10000)4mLに塩酸 3mL及び亜鉛1gを加え,以下同様に操作する.
(4) 重金属〈1.07〉 本品2.0gをとり,第2法により操作 し,試験を行う.比較液には鉛標準液2.0mLを加える (10ppm以下).
(5) 硫酸呈色物〈1.15〉 本品0.5gをとり,試験を行う. ただし,90℃で1時間加熱し,直ちに急冷する.液の色は色 の比較液Kより濃くない.

貯法

容器 気密容器.

強熱残分

0.1%以下(1g).

説明

Citric acid is a white, crystalline, weak organic acid present in most plants and many animals as an intermediate in cellular respiration. Citric acid contains three carboxyl groups making it a carboxylic, more specifically a tricarboxylic, acid.the name citrus originates from the Greek kedromelon meaning apple of melon for the fruit citron. Greek works mention kitron, kitrion, or kitreos for citron fruit, which is an oblong fruit several inches long from the scrublike tree Citrus medica. Lemons and limes have high citric acid content, which may account for up to 8% of the fruit’s dry weight.
Citric acid is a weak acid and loses hydrogen ions from its three carboxyl groups (COOH) in solution.the loss of a hydrogen ion from each group in the molecule results in the citrate ion,C3H5O(COO)3 3?. A citric acid molecule also forms intermediate ions when one or two hydrogen atoms in the carboxyl groups ionize.the citrate ion combines with metals to form salts, the most common of which is calcium citrate. Citric acid forms esters to produce various citrates, for example trimethyl citrate and triethyl citrate.

化学的特性

CITRIC ACID, white crystalline solid, decomposes at higher temperatures, sp gr 1.542. Citric acid is soluble in H2O or alcohol and slightly soluble in ether. The compound is a tribasic acid, forming mono-, di-, and tri- series of salts and esters.

化学的特性

Citric acid is a weak organic acid with the formula C6H8O7. It is a natural preservative / conservative and is also used to add an acidic, or sour, taste to foods and soft drinks. In biochemistry, the conjugate base of citric acid, citrate, is important as an intermediate in the citric acid cycle, which occurs in the metabolism of all aerobic organisms.
Citric acid is a commodity chemical, and more than a million tonnes are produced every year by fermentation. It is used mainly as an acidifier, as a flavoring, and as a chelating agent.

天然物の起源

Citric acid exists in greater than trace amounts in a variety of fruits and vegetables, most notably citrus fruits. Lemons and limes have particularly high concentrations of the acid; it can constitute as much as 8 % of the dry weight of these fruits (about 47 g/L in the juices ) . The concentrations of citric acid in citrus fruits range from 0.005 mol/L for oranges and grapefruits to 0.30 mol/L in lemons and limes. Within species, these values vary depending on the cultivar and the circumstances in which the fruit was grown.

来歴

The discovery of citric acid is credited to Jabir ibn Hayyan (Latin name Geber, 721–815). Citric acid wasfirst isolated in 1784 by the Swedish chemist Carl Wilhelm Scheele (1742–1786), who crystallized it from lemon juice.

使用

Citric Acid is an acidulant and antioxidant produced by mold fer- mentation of sugar solutions and by extraction from lemon juice, lime juice, and pineapple canning residue. it is the predominant acid in oranges, lemons, and limes. it exists in anhydrous and mono- hydrate forms. the anhydrous form is crystallized in hot solutions and the monohydrate form is crystallized from cold (below 36.5°c) solutions. anhydrous citric acid has a solubility of 146 g and mono- hydrate citric acid has a solubility of 175 g/100 ml of distilled water at 20°c. a 1% solution has a ph of 2.3 at 25°c. it is a hygroscopic, strong acid of tart flavor. it is used as an acidulant in fruit drinks and carbonated beverages at 0.25–0.40%, in cheese at 3–4%, and in jellies. it is used as an antioxidant in instant potatoes, wheat chips, and potato sticks, where it prevents spoilage by trapping the metal ions. it is used in combination with antioxidants in the processing of fresh frozen fruits to prevent discoloration.

使用

An organic acid obtained from lemon or lime. The colorless crystals of this acid are soluble in water and alcohol but less so in ether. It was used as a chemical restrainer particularly in developers for the collodion process and in silver nitrate solutions used for sensitizing salted and albumen papers.

使用

Citric acid is a weak organic acid that is known as a commodity chemical, as more than a million tonnes are produced every year by mycological fermentation on an industrial scale using crude sugar sol utions, such as molasses and strains of Aspergillus niger. Citric acid is widely distributed in plants and in animal tissues and fluids and exist in greater than grace amounts in variety of fruits and vegetables, most notably in citrus fruits such as lemon and limes. Citric acid is mainly used as an acidifier, flavoring agent and chelating agent.

使用

citric acid has astringent and anti-oxidant properties. It can also be used as a product stabilizer, pH adjuster, and preservative with a low sensitizing potential. It is not usually irritating to normal skin, but it can cause burning and redness when applied to chapped, cracked, or otherwise inflamed skin. It is derived from citrus fruits.

定義

ChEBI: A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.

製造方法

By mycological fermentation using molasses and strains of Aspergillus niger; from citrus juices and pineapple wastes

Biotechnological Production

Fermentation is the technology of choice for citric acid synthesis. Different bacteria (e.g. Arthrobacter paraffinens and Bacillus licheniformis), filamentous fungi (e.g. Aspergilus niger and Penicillium citrinum) and yeasts (e.g. Candida tropicalis and Yarrowia lipolytica) are able to produce citric acid. Due to high productivity and easy handling, citric acid is usually produced by fermentation with A. niger. For example, a product concentration of 114 g.L-1 within 168 h has been reached by cultivation of A. niger GCMC 7 on cane molasses . On the industrial scale, submerged cultivation, surface fermentation and solid-state fermentation are used.
In general, molasses, starch hydrolyzate and starch are used as substrates. However, there are various studies for alternative raw materials. Solid-state fermentation of inexpensive agricultural wastes is one possibility. For example, high yields up to 88 % have been achieved using grape pomace as substrate. Lowering the cost of product recovery is crucial. Different methods using precipitation, solvent extraction, adsorption, or in situ product recovery have been described. One interesting process could be the in situ crystallization of citric acid during fermentation to improve the economics.

Aroma threshold values

By mycological fermentation using molasses and strains of Aspergillus niger; from citrus juices and pineapple wastes

一般的な説明

Colorless, odorless crystals with an acid taste. Denser than water.

空気と水の反応

The pure material is moisture sensitive (undergoes slow hydrolysis) Water soluble.

反応プロフィール

Citric acid reacts with oxidizing agents, bases, reducing agents and metal nitrates . Reactions with metal nitrates are potentially explosive. Heating to the point of decomposition causes emission of acrid smoke and fumes [Lewis].

健康ハザード

Inhalation of dust irritates nose and throat. Contact with eyes causes irritation.

火災危険

Behavior in Fire: Melts and decomposes. The reaction is not hazardous.

生物活性

Commonly used laboratory reagent

生物学的応用

Citric acid cycle
Citrate, the conjugate base of citric acid is one of a series of compounds involved in the physiological oxidation of fats, proteins, and carbohydrates to carbon dioxide and water.
This series of chemical reactions is central to nearly all metabolic reactions, and is the source of two-thirds of the foodderived energy in higher organisms. Hans Adolf Krebs received the 1953 Nobel Prize in Physiology or Medicine for the discovery. The series of reactions is known by various names, including the "citric acid cycle", the "Krebs cycle" or "Szent-Gy?rgyi — Krebs cycle", and the "tricarboxylic acid (TCA) cycle".
Other biological roles
Citrate is a critical component of bone, helping to regulate the size of calcium crystals.

安全性プロファイル

Poison by intravenous route. Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic byingestion. A severe eye and moderate skin irritant. An irritating organic acid, some allergenic properties. Combustible liquid. Potentially explosive reaction with metal nitrates. When heated to decomposition it emits acrid smoke and fumes.

くえん酸 上流と下流の製品情報

原材料

準備製品


くえん酸 生産企業

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77-92-9(くえん酸)キーワード:


  • 77-92-9
  • C6H8O7H20
  • Citric Acid Anhydrous,citric acid anhydrous bp,citric acid anhydrous
  • Citric acid, AR,≥99.5%(T)
  • Citric acid anhydrou
  • anhydrouscitricacid
  • beta-Hydroxytricarballylic acid
  • beta-hydroxytricarballylicacid
  • beta-hydroxy-tricarboxylicacid
  • AMMONIACAL AMMONIUM CHLORIDE BUFFER
  • BETZ 6251
  • BETZ 0623
  • BORIC ACID-POTASSIUM CHLORIDE-SODIUM HYDROXIDE BUFFER
  • BUFFER CONCENTRATE, PH 7.00
  • BUFFER CONCENTRATE, PH 8.00
  • BUFFER CONCENTRATE, PH 9.00
  • BUFFER CONCENTRATE, PHOSPHATE/SODIUM HYDROXIDE
  • BUFFER CONCENTRATE, POTASSIUM CHLORIDE/SODIUM HYDROXIDE
  • BUFFER CONCENTRATE, BORATE/HYDROCHLORIC ACID
  • BUFFER CONCENTRATE, BORIC ACID/POTASSIUM CHLORIDE/SODIUM HYDROXIDE
  • BUFFER CONCENTRATE, CITRATE/HYDROCHLORIC ACID
  • BUFFER CONCENTRATE, CITRATE/SODIUM HYDROXIDE
  • BUFFER CONCENTRATE, GLYCINE/HYDROCHLORIC ACID
  • BUFFER CONCENTRATE, PH 4.00
  • BUFFER CONCENTRATE, PH 5.00
  • BUFFER CONCENTRATE, PH 1.00
  • BUFFER CONCENTRATE, PH 10.00
  • BUFFER CONCENTRATE, PH 11.00
  • BUFFER CONCENTRATE, PH 12.00
  • BUFFER CONCENTRATE, PH 13.00
  • BUFFER CONCENTRATE, PH 2.00
  • くえん酸
  • β-ヒドロキシトリカルバリル酸
  • シトレッテン
  • 2-ヒドロキシ-1,2,3-プロパントリカルボン酸
  • 2-ヒドロキシプロパン-1,2,3-トリカルボン酸
  • アシレッテン
  • シトロ
  • 枸櫞酸
  • 3-カルボキシ-3-ヒドロキシペンタン-1,5-二酸
  • くえん酸,無水
  • くえん酸(無水)
  • 2W/V% くえん酸溶液
  • クエン酸 TESTED ACCORDING TO PH.EUR.,ANHYDROUS,GRIT
  • くえん酸〔無水〕
  • 無水クエン酸
  • くえん酸、無水
  • 無水クエン酸 (JP17)
  • 代謝産物
  • 抗凝固薬
  • 殺菌薬
  • 着香料
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