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2-Propylpentansäure Produkt Beschreibung

2-Propylpentanoic acid Struktur
99-66-1
CAS-Nr.
99-66-1
Bezeichnung:
2-Propylpentansäure
Englisch Name:
2-Propylpentanoic acid
Synonyma:
VPA;44089;Epilim;Ergenyl;depakote;Mylproin;Valproic;Convulex;Depakene;Depakine
CBNumber:
CB7149528
Summenformel:
C8H16O2
Molgewicht:
144.21
MOL-Datei:
99-66-1.mol

2-Propylpentansäure Eigenschaften

Schmelzpunkt:
-21.25°C (estimate)
Siedepunkt:
220 °C(lit.)
Dichte
0.92
Dampfdruck
0.01 hPa (20 °C)
Brechungsindex
n20/D 1.425(lit.)
Flammpunkt:
232 °F
storage temp. 
2-8°C
Löslichkeit
H2O: slightly soluble
Aggregatzustand
Liquid
pka
4.6(at 25℃)
Farbe
Clear colorless to pale yellow
Explosionsgrenze
1%(V)
Wasserlöslichkeit
slightly soluble
Merck 
14,9913
BRN 
1750447
CAS Datenbank
99-66-1(CAS DataBase Reference)
NIST chemische Informationen
Valproic Acid(99-66-1)
EPA chemische Informationen
Pentanoic acid, 2-propyl-(99-66-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,T,F
R-Sätze: 22-36/37/38-39/23/24/25-23/24/25-11-34-61
S-Sätze: 26-45-36/37-16-7-36/37/39-53
RIDADR  UN 1230 3/PG 2
WGK Germany  3
RTECS-Nr. YV7875000
HazardClass  8
PackingGroup  III
HS Code  29159080
Giftige Stoffe Daten 99-66-1(Hazardous Substances Data)
Toxizität LD50 orally in rats: 670 mg/kg (Jenner)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H314 Verursacht schwere Verätzungen der Haut und schwere Augenschäden. Ätzwirkung auf die Haut Kategorie 1B Achtung P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augenschäden. Schwere Augenschädigung Kategorie 1 Achtung P280, P305+P351+P338, P310
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P309 BEI Exposition oder Unwohlsein:
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

2-Propylpentansäure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

Colorless Liquid

Verwenden

Antiepileptic; increases levels of -aminobutyric acid(GABA) in the brain. Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Verwenden

Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.

Verwenden

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures asso

Definition

ChEBI: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Trademarks

Depakene (Abbott);Valproine;Vederon.

Biologische Funktion

Although it is marketed as both valproic acid (Depakene) and as sodium valproate (Depakote), it is the valproate ion that is absorbed from the gastrointestinal tract and is the active form.
As with several other AEDs, it is difficult to ascribe a single mechanism of action to valproic acid.This compound has broad anticonvulsant activity, both in experimental studies and in the therapeutic management of human epilepsy.Valproic acid has been shown to block voltage-dependent sodium channels at therapeutically relevant concentrations. In several experimental studies, valproate caused an increase in brain GABA; the mechanism was unclear.There is evidence that valproate may also inhibit T-calcium channels and that this may be important in its mechanism of action in patients with absence epilepsy.

Allgemeine Beschreibung

VPA is an established AED with a simple chemical structurebut an unusually broad spectrum of action. It is generallywell tolerated, but its use is limited by two rare but significanttoxic side effects (hepatotoxicity and teratogenicity) thatcan be dose-dependent or idiosyncratic in nature.Thesedrawbacks are apparently shared by its equipotent activemetabolite, (E)-2-propyl-2-pentenoic acid (2-ene-VPA).
VPA is also an important inhibitor of the cytochrome P450isozymes, mainly of CYP2C9 and also of uridine diphosphate(UDP)-glucuronyl transferase and epoxide hydrolase.

Allgemeine Beschreibung

Clear colorless liquid.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

2-Propylpentanoic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 2-Propylpentanoic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. 2-Propylpentanoic acid is incompatible with bases, oxidizing agents and reducing agents. 2-Propylpentanoic acid is corrosive. .

Brandgefahr

2-Propylpentanoic acid is combustible.

Clinical Use

Valproic acid is well absorbed from the gastrointestinal tract and is highly bound (~90%) to plasma protein, and most of the compound is therefore retained within the vascular compartment.Valproate rapidly enters the brain from the circulation; the subsequent decline in brain concentration parallels that in plasma, indicating equilibration between brain and capillary blood. A large number of metabolites have been identified, but it is not known whether they play a role in the anticonvulsant effect of the parent drug. Valproic acid inhibits the metabolism of several drugs, including phenobarbital, primidone, carbamazepine, and phenytoin, leading to an increased blood level of these compounds. At high doses, valproic acid can inhibit its own metabolism. It can also displace phenytoin from binding sites on plasma proteins, with a resultant increase in unbound phenytoin and increased phenytoin toxicity. In this instance, the dosage of phenytoin should be adjusted as required. These examples reinforce the need to determine serum anticonvulsant levels in epileptic patients when polytherapy is employed.
Valproic acid has become a major AED against several seizure types. It is highly effective against absence seizures and myoclonic seizures. In addition, valproic acid can be used either alone or in combination with other drugs for the treatment of generalized tonic– clonic epilepsy and for partial seizures with complex symptoms.

Nebenwirkungen

The most serious adverse effect associated with valproic acid is fatal hepatic failure. Fatal hepatotoxicity is most likely to occur in children under age 2 years, especially in those with severe seizures who are given multiple anticonvulsant drug therapy. The hepatotoxicity is not dose related and is considered an idiosyncratic reaction; it can occur in individuals in other age groups, and therefore, valproic acid should not be administered to patients with hepatic disease or significant hepatic dysfunction or to those who are hypersensitive to it. Valproic acid administration has been linked to an increased incidence of neural tube defects in the fetus of mothers who received valproate during the first trimester of pregnancy. Patients taking valproate may develop clotting abnormalities.
Valproic acid causes hair loss in about 5% of patients, but this effect is reversible. Transient gastrointestinal effects are common, and some mild behavioral effects have been reported. Metabolic effects, including hyperglycemia, hyperglycinuria, and hyperammonemia, have been reported. An increase in body weight also has been noted. Valproic acid is not a CNS depressant, but its administration may lead to increased depression if it is used in combination with phenobarbital, primidone, benzodiazepines, or other CNS depressant agents.

2-Propylpentansäure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-Propylpentansäure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 215)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21707 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 693 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58

99-66-1(2-Propylpentansäure)Verwandte Suche:


  • Propylvaleric acid
  • Valeric acid, 2-propyl-
  • Valericacid,2-propyl-
  • valproate
  • Valproesαure
  • valproicacid(INN)
  • DI-N-PROPYLACETIC ACID
  • DIPROPYLACETIC ACID
  • DIVALPROEX
  • 2,2-DI-N-PROPYLACETIC ACID
  • Dipropylacetic Acid Valproic Acid 2-Propylpentanoic Acid
  • Valproic Acid(Dipropylacetic acid)
  • 2-PROPYLVALERIC ACID FOR SYNTHESIS
  • VPA
  • Valproic acid USP/EP
  • Valproic acid for system suitability
  • Valproic acid solution
  • DI PROPYL ACETIC ACID (VALPROIC ACID)
  • (n-C3H7)2CHCOOH
  • 2 PP (base)
  • 2-n-Propylpentanoicacid
  • 2-n-Propylvalericacid
  • 2-Propylpentansαure
  • depakote
  • Di-n-propylessigsaure
  • dipropyl-aceticaci
  • Epilim
  • Ergenyl
  • Heptane-4-carboxylicacid
  • Kyselina 2-propylvalerova
  • kyselina2-propylvalerova
  • Mylproin
  • n-Dipropylacetic acid
  • n-dipropylaceticacid
  • Pentanoic acid, 2-propyl-
  • Pentanoicacid,2-propyl-
  • 2-N-PROPYL-N-VALERIC ACID
  • 2-PROPYLVALERIC ACID
  • 2-PROPYLPENTANOIC ACID
  • VALPROIC ACID
  • Sodio divalproato
  • Valproic acid USP24
  • 2-PROPYLPENTANOIC ACID FREE ACID
  • VALPROIC ACID USP 98-102%
  • 2,2-Di-n-propylacetic acid, 98+% (Valproic acid)
  • Valproic
  • 2-propylpentanoic acid solution
  • (R)-VALPROICACID
  • (S)-VALPROICACID
  • 2,2-DIPROPYLACETICACID
  • DIPROPYL-2,2-ACETICACID
  • NSC 93819
  • 2,2-Di-n-propylacetic acid, 98+%
  • 2-Propylpentanoic acid,99%
  • (CH3CH2CH2)2CHCOOH
  • ValproicacidBP/USP
  • Valproic acid ,99%
  • Valproic Acid (500 mg)
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