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グリシン

グリシン 化学構造式
56-40-6
CAS番号.
56-40-6
化学名:
グリシン
别名:
グリシン;グリシン [電気泳動用];アミノ酢酸;グリココール;アミノ酢酸(グリシン);グリシン CRM6022‐A;1 Mグリシン 溶液;グリシン (JP17)
英語化学名:
Glycine
英語别名:
TG;TGC;Gly;Padil;L-Gly;Gly-OH;Iconyl;TGase C;Aciport;Glycine
CBNumber:
CB5336487
化学式:
C2H5NO2
分子量:
75.07
MOL File:
56-40-6.mol

グリシン 物理性質

融点 :
240 °C (dec.) (lit.)
沸点 :
233°C
比重(密度) :
1.595
蒸気圧:
0.0000171 Pa (25 °C)
FEMA :
3287 | GLYCINE
屈折率 :
1.4264 (estimate)
闪点 :
176.67°C
貯蔵温度 :
2-8°C
溶解性:
H2O: 100 mg/mL
外見 :
powder
酸解離定数(Pka):
2.35(at 25℃)
色:
<5 (200 mg/mL)(APHA)
臭い (Odor):
Odorless
PH:
4(0.2 molar aqueous solution)
酸塩基指示薬変色域(pH):
4
水溶解度 :
25 g/100 mL (25 ºC)
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number:
1421
Merck :
14,4491
BRN :
635782
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey:
DHMQDGOQFOQNFH-UHFFFAOYSA-N
CAS データベース:
56-40-6(CAS DataBase Reference)
NISTの化学物質情報:
Glycine(56-40-6)
EPAの化学物質情報:
Glycine (56-40-6)

安全性情報

Rフレーズ  33
Sフレーズ  22-24/25
WGK Germany  2
RTECS 番号 MB7600000
TSCA  Yes
HSコード  29224910
有毒物質データの 56-40-6(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 7930 mg/kg
化審法 (9)-77 届出不要化学物質

グリシン 価格 もっと(103)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00007340 グリシン
Glycine
56-40-6 100mg ¥17900 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00007340 グリシン
Glycine
56-40-6 1g ¥32500 2020-09-21 購入
東京化成工業 G0099 グリシン >99.0%(T)
Glycine >99.0%(T)
56-40-6 25g ¥1800 2022-04-26 購入
東京化成工業 G0099 グリシン >99.0%(T)
Glycine >99.0%(T)
56-40-6 500g ¥3500 2022-04-26 購入
関東化学株式会社(KANTO) 01194-23 グリシン >99.0%
Glycine >99.0%
56-40-6 100g ¥1500 2022-04-26 購入

グリシン MSDS


Monazol

グリシン 化学特性,用途語,生産方法

外観

白色の結晶性粉末

定義

本品は、次の化学式で表されるアミノ酸である。

溶解性

水に溶けやすく、エタノール及びジエチルエーテルにほとんど溶けない。

解説

aminoacetic acid.C2H5NO2(75.07).H2NCH2COOH.略号Gly.グリココルともいう.もっとも簡単なα-アミノ酸で,生体アミノ酸のなかで唯一不斉炭素原子をもたない.動物,植物にタンパク質構成アミノ酸として,または遊離の形で広く分布している.大豆ミール,くずまゆ,絹フィブロイン,ゼラチンなどの加水分解物からエチルエステル塩酸塩や金属塩として分離される.実験室的には,ホルムアルデヒドとシアン化水素とアンモニアから合成する(ストレッカーのアミノ酸合成),工業的には,モノクロロ酢酸とアンモニアから合成する.分解点292 ℃.pK1 2.34,pK2 9.60.pI5.97.苦味がある.医薬,食料品加工,ほかのアミノ酸の合成原料などに用いられる.[CAS 56-40-6]
森北出版「化学辞典(第2版)

用途

食品類醸造用原料( 添加物) 、医薬中間原料

化粧品の成分用途

ヘアコンディショニング剤、緩衝剤、皮膚コンディショニング剤

効能

グリシン補充薬

確認試験

本品を乾燥し,赤外吸収スペクトル測定法〈2.25〉 の臭化カリウム錠剤法により試験を行い,本品のスペクトル と本品の参照スペクトルを比較するとき,両者のスペクトル は同一波数のところに同様の強度の吸収を認める.もし,こ れらのスペクトルに差を認めるときは,本品を水に溶かし, 蒸発乾燥したものにつき,同様の試験を行う.

定量法

本品を乾燥し,その約80mgを精密に量り,ギ酸3mL に溶かし,酢酸(100)50mLを加え,0.1mol/L過塩素酸で滴 定〈2.50〉する(電位差滴定法).同様の方法で空試験を行い, 補正する.

純度試験

(1) 溶状 本品1.0gを水10mLに溶かすとき,液は無色澄 明である.
(2) 塩化物〈1.03〉 本品0.5gをとり,試験を行う.比較 液には0.01mol/L塩酸0.30mLを加える(0.021%以下).
(3) 硫酸塩〈1.14〉 本品0.6gをとり,試験を行う.比較 液には0.005mol/L硫酸0.35mLを加える(0.028%以下).
(4) アンモニウム〈1.02〉 本品0.25gをとり,試験を行う. 比較液にはアンモニウム標準液5.0mLを用いる(0.02%以下). (5) 重金属〈1.07〉 本品1.0gをとり,第1法により操作し, 試験を行う.比較液には鉛標準液2.0mLを加える(20ppm以 下).
(6) ヒ素 本品1.0gをとり,第1法により操作し, 試験を行う(2ppm以下).
(7) 類縁物質 本品0.10gを水25mLに溶かし,試料溶液 とする.この液1mLを正確に量り,水を加えて正確に50mL とする.この液5mLを正確に量り,水を加えて正確に20mL とし,標準溶液とする.これらの液につき,薄層クロマトグ ラフィー〈2.03〉により試験を行う.試料溶液及び標準溶液 5μLずつを薄層クロマトグラフィー用シリカゲルを用いて調 製した薄層板にスポットする.次に1-ブタノール/水/酢 酸(100)混液(3:1:1)を展開溶媒として約10cm展開した後, 薄層板を80℃で30分間乾燥する.これにニンヒドリンのア セトン溶液(1→50)を均等に噴霧した後,80℃で5分間加熱 するとき,試料溶液から得た主スポット以外のスポットは, 標準溶液から得たスポットより濃くない.

貯法

容器 密閉容器.

乾燥減量

0.30%以下(1g,105℃,3時間).

強熱残分

0.1%以下(1g).

説明

Glycine (abbreviated as Gly or G) is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its side-chain, glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG of the genetic code.
Glycine is a colourless, sweet-tasting crystalline solid. It is unique among the proteinogenic amino acids in that it is not chiral. It can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom. Glycine is also the genus name of the Soybean plant (species name = Glycine max).

化学的特性

Glycine occurs as a white, odorless, crystalline powder, and has a sweet taste.

天然物の起源

Gelatin and silk fbroin are reportedly the best natural sources of this amino acid

使用

Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

定義

ChEBI: The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.

製造方法

From chloroacetic acid and ammonia; from protein sources, such as gelatin and silk fbroin; from ammonium bicarbonate and sodium cyanide; by catalytic cleavage of serine; from hydrobromic acid and methyleneaminoacetonitrile.

調製方法

Chemical synthesis is the most suitable method of preparation of glycine. Amination of chloroacetic acid and the hydrolysis of aminoacetonitrile are the favored methods of production.

生合成

Glycine is not essential to the human diet, as it is biosynthesized in the body from the amino acid serine, which is in turn derived from 3-phospho glycerate. In most organisms, the enzyme Serine hydroxy methyl transferase catalyses this transformation via the cofactor pyridoxal phosphate :
serine + tetra hydro folate → glycine +N5,N10-Methylene tetrahydrofolate + H2O
In the liver of vertebrates, glycine synthesis is catalyzed by glycine synthase (also called glycine cleavage enzyme). This conversion is readily reversible : CO2 + NH4+ + N5,N10-Methylene tetra hydro folate + NADH + H+→ Glycine + tetrahydrofolate +NAD+
Glycine is coded by codons GGU, GGC, GGA and GGG. Most proteins incorporate only small quantities of glycine. A notable exception is collagen, which contains about 35 % glycine.

生物学の機能

The principal function of glycine is as a precursor to proteins. It is also a building block to numerous natural products.
As a biosynthetic intermediate
In higher eukaryotes, D-Aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from glycine and succinyl-CoA. Glycine provides the central C2N subunit of all purines.
As a neurotransmitter
Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an Inhibitory postsynaptic potentia (IPSP). Strychnine is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. Glycine is a required coagonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the (NMDA) glutaminergic receptors which are excitatory. The LD50 of glycine is 7930 mg / kg in rats (oral), and it usually causes death by hyperexcitability. .

一般的な説明

White crystals.

空気と水の反応

Water soluble.

反応プロフィール

An amino acid. A 0.2M aqueous solution has a pH of 4.0., so acts as a weak acid. Has characteristics of both acid and base.

危険性

Use in fats restricted to 0.01%.

火災危険

LOW. Ignites at very high temperatures.

农业用途

Glycine is the simplest naturally occurring amino acid and is a constituent of most proteins. Its formula is H2N·CH2·COOH.

応用例(製薬)

Glycine is routinely used as a cofreeze-dried excipient in protein formulations owing to its ability to form a strong, porous, and elegant cake structure in the final lyophilized product. It is one of the most frequently utilized excipients in freeze-dried injectable formulations owing to its advantageous freeze-drying properties.
Glycine has been investigated as a disintegration accelerant in fast-disintegrating formulations owing to its excellent wetting nature.It is also used as a buffering agent and conditioner in cosmetics.
Glycine may be used along with antacids in the treatment of gastric hyperacidity, and it may also be included in aspirin preparations to aid the reduction of gastric irritation.

生物活性

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

安全性プロファイル

Moderately toxic by intravenous route. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

安全性

Glycine is used as a sweetener, buffering agent, and dietary supplement. The pure form of glycine is moderately toxic by the IV route and mildly toxic by ingestion.
Systemic absorption of glycine irrigation solutions can lead to disturbances of fluid and electrolyte balance and cardiovascular and pulmonary disorders.
LD50 (mouse, IP): 4.45 g/kg
LD50 (mouse, IV): 2.37 g/kg
LD50 (mouse, oral): 4.92 g/kg
LD50 (mouse, SC): 5.06 g/kg
LD50 (rat, IV): 2.6 g/kg
LD50 (rat, oral): 7.93 g/kg
LD50 (rat, SC): 5.2 g/kg

貯蔵

Glycine starts to decompose at 233°C. Store in well-closed containers. Glycine irrigation solutions (95–105% glycine) should be stored in single dose containers, preferably type I or type II glass.

純化方法

Crystallise glycine from distilled water by dissolving at 90-95o, filtering, cooling to about -5o, and draining the crystals centrifugally. Alternatively, crystallise it from distilled water by addition of MeOH or EtOH (e.g. 50g dissolved in 100mL of warm water, and 400mL of MeOH is added). The crystals are washed with MeOH or EtOH, then with diethyl ether. Likely impurities are ammonium glycinate, iminodiacetic acid, nitrilotriacetic acid or/and ammonium chloride. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1955 1961, Beilstein 4 IV 2349.]

不和合性

Glycine may undergo Maillard reactions with amino acids to produce yellowing or browning. Reducing sugars will also interact with secondary amines to form an imine, but without any accompanying yellow-brown discoloration.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, SC injections; oral; rectal) and approved for irrigant solutions. Included in parenteral (powders for injection; solutions for injection; vaccines; kits for implant) and nonparenteral (orodispersible tablets/oral lyophilizate; powders for inhalation; powders for oral solution; tablets) formulations licensed in the UK.

グリシン 上流と下流の製品情報

原材料

準備製品


グリシン 生産企業

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56-40-6(グリシン)キーワード:


  • 56-40-6
  • BLOTTING BUFFER
  • USP24 GLYCINE USP24
  • GLYCINE TECHNICAL
  • GLYCINE USP
  • Glycine (Feed Grade)
  • Glycine (Food Grade)
  • Glycine (Pharm Grade)
  • Glycine (Tech Grade)
  • Glycine 99.0+ % for analysis
  • Glycine BP
  • Glycine, MB Grade (1.12008)
  • Glycine, USP Grade, Molecular Biology Grade
  • Aminoaceticacid,H-Gly-OH
  • analyticalgrade
  • AMINOACETIC ACID, PHARMA
  • GLYCINE 98.5+% FCC
  • GLYCINE, REAGENTPLUS TM, >= 99%
  • GLYCINE 98.5+% A.C.S. REAGENT
  • GLYCINE, PH EUR
  • ANTIMONY(V) CHLORIDE 99.5%
  • GLYCINE, 99+%
  • GLYCINE, 4X10 G*
  • GLYCINE CALIBRATION MARKER
  • GLYCINE, FOR MOLECULAR BIOLOGY
  • GLYCINE, FOR LUMINESCENCE
  • GLYCINE DAB, PH. EUR., B. P., PH. FRANC.
  • GLYCINE PURISS. P.A., REAG. PH. EUR.,BUFFER SUBSTANCE
  • Glycine 1 M Solution
  • GLYCINE SOLUTION STERILE FILTERED*CELL C ULTURE TEST
  • GLYCINE, ELECTROPHORESIS REAGENT
  • グリシン
  • グリシン [電気泳動用]
  • アミノ酢酸
  • グリココール
  • アミノ酢酸(グリシン)
  • グリシン CRM6022‐A
  • 1 Mグリシン 溶液
  • グリシン (JP17)
  • 電気泳動用試薬
  • 構造分類
  • 生化学
  • α-アミノ酸
  • ω-アミノカルボン酸
  • ω-官能性アルカノール, カルボン酸, アミン & ハライド
  • アミノ酸
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