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グリシン [電気泳動用]

グリシン [電気泳動用] 化学構造式
56-40-6
CAS番号.
56-40-6
化学名:
グリシン [電気泳動用]
别名:
グリシン;グリシン [電気泳動用];アミノ酢酸;グリココール;アミノ酢酸(グリシン);グリシン CRM6022‐A;1 Mグリシン 溶液;グリシン (JP17)
英語化学名:
Glycine
英語别名:
TG;Gly;TGC;L-Gly;Padil;Iconyl;Gly-OH;Glycine;Monazol;Amitone
CBNumber:
CB5336487
化学式:
C2H5NO2
分子量:
75.07
MOL File:
56-40-6.mol

グリシン [電気泳動用] 物理性質

融点 :
240 °C (dec.)(lit.)
沸点 :
233°C
比重(密度) :
1.595
蒸気圧:
0.0000171 Pa (25 °C)
FEMA :
3287 | GLYCINE
屈折率 :
1.4264 (estimate)
闪点 :
176.67°C
貯蔵温度 :
2-8°C
溶解性:
H2O: 100 mg/mL
外見 :
powder
酸解離定数(Pka):
2.35(at 25℃)
色:
<5 (200 mg/mL)(APHA)
PH:
4(0.2 molar aqueous solution)
水溶解度 :
25 g/100 mL (25 ºC)
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number:
1421
Merck :
14,4491
BRN :
635782
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey:
DHMQDGOQFOQNFH-UHFFFAOYSA-N
CAS データベース:
56-40-6(CAS DataBase Reference)
NISTの化学物質情報:
Glycine(56-40-6)
EPAの化学物質情報:
Glycine(56-40-6)

安全性情報

Rフレーズ  33
Sフレーズ  22-24/25
WGK Germany  2
RTECS 番号 MB7600000
TSCA  Yes
HSコード  29224910
有毒物質データの 56-40-6(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 7930 mg/kg
化審法 (9)-77 届出不要化学物質

グリシン [電気泳動用] 価格 もっと(95)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00007340 グリシン
Glycine
56-40-6 100mg ¥13400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00007340 グリシン
Glycine
56-40-6 1g ¥19300 2018-12-26 購入
東京化成工業 G0099 グリシン >99.0%(T)
Glycine >99.0%(T)
56-40-6 25g ¥1600 2018-12-04 購入
東京化成工業 G0099 グリシン >99.0%(T)
Glycine >99.0%(T)
56-40-6 500g ¥3300 2018-12-04 購入
関東化学株式会社(KANTO) 01194-00 グリシン >99.0%(T)
Glycine >99.0%(T)
56-40-6 500g ¥2500 2018-12-13 購入

グリシン [電気泳動用] MSDS


Monazol

グリシン [電気泳動用] 化学特性,用途語,生産方法

外観

白色の結晶性粉末

定義

本品は、次の化学式で表されるアミノ酸である。

溶解性

水に溶けやすく、エタノール及びジエチルエーテルにほとんど溶けない。

用途

食品類醸造用原料( 添加物) 、医薬中間原料

化粧品の成分用途

ヘアコンディショニング剤、緩衝剤、皮膚コンディショニング剤

効能

グリシン補充薬

確認試験

本品を乾燥し,赤外吸収スペクトル測定法〈2.25〉 の臭化カリウム錠剤法により試験を行い,本品のスペクトル と本品の参照スペクトルを比較するとき,両者のスペクトル は同一波数のところに同様の強度の吸収を認める.もし,こ れらのスペクトルに差を認めるときは,本品を水に溶かし, 蒸発乾燥したものにつき,同様の試験を行う.

定量法

本品を乾燥し,その約80mgを精密に量り,ギ酸3mL に溶かし,酢酸(100)50mLを加え,0.1mol/L過塩素酸で滴 定〈2.50〉する(電位差滴定法).同様の方法で空試験を行い, 補正する.

純度試験

(1) 溶状 本品1.0gを水10mLに溶かすとき,液は無色澄 明である.
(2) 塩化物〈1.03〉 本品0.5gをとり,試験を行う.比較 液には0.01mol/L塩酸0.30mLを加える(0.021%以下).
(3) 硫酸塩〈1.14〉 本品0.6gをとり,試験を行う.比較 液には0.005mol/L硫酸0.35mLを加える(0.028%以下).
(4) アンモニウム〈1.02〉 本品0.25gをとり,試験を行う. 比較液にはアンモニウム標準液5.0mLを用いる(0.02%以下). (5) 重金属〈1.07〉 本品1.0gをとり,第1法により操作し, 試験を行う.比較液には鉛標準液2.0mLを加える(20ppm以 下).
(6) ヒ素 本品1.0gをとり,第1法により操作し, 試験を行う(2ppm以下).
(7) 類縁物質 本品0.10gを水25mLに溶かし,試料溶液 とする.この液1mLを正確に量り,水を加えて正確に50mL とする.この液5mLを正確に量り,水を加えて正確に20mL とし,標準溶液とする.これらの液につき,薄層クロマトグ ラフィー〈2.03〉により試験を行う.試料溶液及び標準溶液 5μLずつを薄層クロマトグラフィー用シリカゲルを用いて調 製した薄層板にスポットする.次に1-ブタノール/水/酢 酸(100)混液(3:1:1)を展開溶媒として約10cm展開した後, 薄層板を80℃で30分間乾燥する.これにニンヒドリンのア セトン溶液(1→50)を均等に噴霧した後,80℃で5分間加熱 するとき,試料溶液から得た主スポット以外のスポットは, 標準溶液から得たスポットより濃くない.

貯法

容器 密閉容器.

乾燥減量

0.30%以下(1g,105℃,3時間).

強熱残分

0.1%以下(1g).

説明

Glycine (abbreviated as Gly or G) is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its side-chain, glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG of the genetic code.
Glycine is a colourless, sweet-tasting crystalline solid. It is unique among the proteinogenic amino acids in that it is not chiral. It can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom. Glycine is also the genus name of the Soybean plant (species name = Glycine max).

化学的特性

Glycine occurs as a white, odorless, crystalline powder, and has a sweet taste.

化学的特性

White or almost white, crystalline powder

使用

Non-essential amino acid for human development. An inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

使用

Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

使用

Glycine is a nonessential amino acid that functions as a nutrient and dietary supplement. it has a solubility of 1 g in 4 ml of water and is abundant in collagen. it is used to mask the bitter aftertaste of sac- charin, for example, in artificially sweetened soft drinks. it retards rancidity in fat.

使用

glycine is an amino acid used as a texturizer in cosmetic formulations. It makes up approximately 30 percent of the collagen molecule.

使用

In the US, glycine is typically sold in two grades: United States Pharmacopeia (“USP”), and technical grade. Most glycine is manufactured as USP grade material for diverse uses. USP grade sales account for approximately 80 to 85 percent of the U.S. market for glycine.
Pharmaceutical grade glycine is produced for some pharmaceutical applications, such as intravenous injections, where the customer’s purity requirements often exceed the minimum required under the USP grade designation. Pharmaceutical grade glycine is often produced to proprietary specifications and is typically sold at a premium over USP grade glycine.
Technical grade glycine, which may or may not meet USP grade standards, is sold for use in industrial applications; e.g., as an agent in metal complexing and finishing. Technical grade glycine is typically sold at a discount to USP grade glycine.
Animal and human foods
Other markets for USP grade glycine include its use an additive in pet food and animal feed. For humans, glycine is sold as a sweetener/taste enhancer. Certain food supplements and protein drinks contain glycine. Certain drug formulations include glycine to improve gastric absorption of the drug.
Cosmetics and miscellaneous applications
Glycine serves as a buffering agent in antacids, analgesics, antiperspirants, cosmetics, and toiletries.
Many miscellaneous products use glycine or its derivatives, such as the production of rubber sponge products, fertilizers, metal complexants.
Chemical feed stock
Glycine is an intermediate in the synthesis of a variety of chemical products. It is used in the manufacture of the herbicide glyphosate. Glyphosate is a non-selective systemic herbicide used to kill weeds, especially perennials and broadcast or used in the cutstump treatment as a forestry herbicide.

調製方法

Chemical synthesis is the most suitable method of preparation of glycine. Amination of chloroacetic acid and the hydrolysis of aminoacetonitrile are the favored methods of production.

定義

ChEBI: The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.

調製方法

Glycine was discovered in 1820, by Henri Braconnot who boiled gelatin with sulfuric acid.
Glycine is manufactured industrially by treating chloroacetic acid with ammonia :
ClCH2COOH + 2 NH3→H2NCH2COOH + NH4Cl
About 15 million kg are produced annually in this way.
In the USA (by GEO Specialty Chemicals, Inc.) and in Japan (by Shoadenko), glycine is produced via the Strecker amino acid synthesis.

生合成

Glycine is not essential to the human diet, as it is biosynthesized in the body from the amino acid serine, which is in turn derived from 3-phospho glycerate. In most organisms, the enzyme Serine hydroxy methyl transferase catalyses this transformation via the cofactor pyridoxal phosphate :
serine + tetra hydro folate → glycine +N5,N10-Methylene tetrahydrofolate + H2O
In the liver of vertebrates, glycine synthesis is catalyzed by glycine synthase (also called glycine cleavage enzyme). This conversion is readily reversible : CO2 + NH4+ + N5,N10-Methylene tetra hydro folate + NADH + H+→ Glycine + tetrahydrofolate +NAD+
Glycine is coded by codons GGU, GGC, GGA and GGG. Most proteins incorporate only small quantities of glycine. A notable exception is collagen, which contains about 35 % glycine.

Biotechnological Production

Glycine is manufactured exclusively by chemical synthesis, and two main processes are practiced today. The direct amination of chloroacetic acid with a large excess of ammonia gives good yields of glycine without producing large amounts of di- and trialkylated products. This process is widely used in China, where the main application of the glycine is as a raw material for the herbicide glyphosate.
The other main process is the Strecker synthesis. The direct Strecker reaction of formaldehyde and ammonium cyanide produces methylene amino acetonitrile, which must be hydrolyzed in two stages to produce glycine . A more efficient approach is to aminate the intermediate glycolonitrile, followed by hydrolysis]. An alternative method, which is more often applied for the homologous amino acids, is the Bucherer–Bergs reaction. Reaction of formaldehyde and ammonium carbonate or bicarbonate gives the intermediate hydantoin, which can be hydrolyzed to glycine in a separate step.

生物学の機能

The principal function of glycine is as a precursor to proteins. It is also a building block to numerous natural products.
As a biosynthetic intermediate
In higher eukaryotes, D-Aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from glycine and succinyl-CoA. Glycine provides the central C2N subunit of all purines.
As a neurotransmitter
Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an Inhibitory postsynaptic potentia (IPSP). Strychnine is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. Glycine is a required coagonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the (NMDA) glutaminergic receptors which are excitatory. The LD50 of glycine is 7930 mg / kg in rats (oral), and it usually causes death by hyperexcitability. .

一般的な説明

White crystals.

空気と水の反応

Water soluble.

反応プロフィール

An amino acid. A 0.2M aqueous solution has a pH of 4.0., so acts as a weak acid. Has characteristics of both acid and base.

危険性

Use in fats restricted to 0.01%.

火災危険

LOW. Ignites at very high temperatures.

农业用途

Glycine is the simplest naturally occurring amino acid and is a constituent of most proteins. Its formula is H2N·CH2·COOH.

応用例(製薬)

Glycine is routinely used as a cofreeze-dried excipient in protein formulations owing to its ability to form a strong, porous, and elegant cake structure in the final lyophilized product. It is one of the most frequently utilized excipients in freeze-dried injectable formulations owing to its advantageous freeze-drying properties.
Glycine has been investigated as a disintegration accelerant in fast-disintegrating formulations owing to its excellent wetting nature.It is also used as a buffering agent and conditioner in cosmetics.
Glycine may be used along with antacids in the treatment of gastric hyperacidity, and it may also be included in aspirin preparations to aid the reduction of gastric irritation.

生物活性

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

安全性プロファイル

Moderately toxic by intravenous route. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

安全性

Glycine is used as a sweetener, buffering agent, and dietary supplement. The pure form of glycine is moderately toxic by the IV route and mildly toxic by ingestion.
Systemic absorption of glycine irrigation solutions can lead to disturbances of fluid and electrolyte balance and cardiovascular and pulmonary disorders.
LD50 (mouse, IP): 4.45 g/kg
LD50 (mouse, IV): 2.37 g/kg
LD50 (mouse, oral): 4.92 g/kg
LD50 (mouse, SC): 5.06 g/kg
LD50 (rat, IV): 2.6 g/kg
LD50 (rat, oral): 7.93 g/kg
LD50 (rat, SC): 5.2 g/kg

貯蔵

Glycine starts to decompose at 233°C. Store in well-closed containers. Glycine irrigation solutions (95–105% glycine) should be stored in single dose containers, preferably type I or type II glass.

純化方法

Crystallise glycine from distilled water by dissolving at 90-95o, filtering, cooling to about -5o, and draining the crystals centrifugally. Alternatively, crystallise it from distilled water by addition of MeOH or EtOH (e.g. 50g dissolved in 100mL of warm water, and 400mL of MeOH is added). The crystals are washed with MeOH or EtOH, then with diethyl ether. Likely impurities are ammonium glycinate, iminodiacetic acid, nitrilotriacetic acid or/and ammonium chloride. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1955 1961, Beilstein 4 IV 2349.]

Degradation

Glycine is degraded via three pathways. The predominant pathway in animals and plants involves the glycine cleavage enzyme Glycine + tetra hydro folate + NAD+ → CO2 + NH4+ + N5,N10-Methylene tetra hydrofolate + NADH + H+ In the second pathway, glycine is degraded in two steps. The first step is the reverse of glycine biosynthesis from serine with serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. In the third pathway of glycine degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction. The half-life of glycine and its elimination from the body varies significantly based on dose. In one study, the half-life was between 0.5 and 4.0 hours.

Presence in space

The detection of glycine in the interstellar medium has been debated . In 2008, the glycine - like molecule amino aceto nitrile was discovered in the Large Molecule Heimat, a giant gas cloud near the galactic center in the constellation Sagittarius by the Max Planck Institute for Radio Astronomy . In 2009, glycine sampled in 2004 from comet Wild 2 by the NASA spacecraft Stardust was confirmed, the first discovery of extraterrestrial glycine. That mission's results bolstered the theory of panspermia, which claims that the "seeds" of life are widespread throughout the universe.

不和合性

Glycine may undergo Maillard reactions with amino acids to produce yellowing or browning. Reducing sugars will also interact with secondary amines to form an imine, but without any accompanying yellow-brown discoloration.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, SC injections; oral; rectal) and approved for irrigant solutions. Included in parenteral (powders for injection; solutions for injection; vaccines; kits for implant) and nonparenteral (orodispersible tablets/oral lyophilizate; powders for inhalation; powders for oral solution; tablets) formulations licensed in the UK.

グリシン [電気泳動用] 上流と下流の製品情報

原材料

準備製品


グリシン [電気泳動用] 生産企業

Global( 568)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hangzhou Bayee Chemical Co., Ltd.
0086-571-86990109; 0086-18605816692
0086-571-85775919 rachelhoo@bayeechem.com China 98 55
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 274 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
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Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
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Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
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56-40-6(グリシン [電気泳動用])キーワード:


  • 56-40-6
  • GLYCINE REAGENT (ACS)
  • glycine, acs
  • GLYCINE 80 MESH
  • GLYCINE,FCC
  • GLYCINE,ULTRAPURE
  • GLYCINE USP 23
  • GLYCINE USP GRADE
  • H-Gly-OH (Physic Grade)
  • Aminoacetic acid
  • Gly
  • Glycine
  • Iconyl
  • Monazol
  • GLYCINE CELL CULTURE GRADE
  • GLYCINE BIOCHEMICA
  • GLYCINE PH. EUR., USP
  • GLYCINE, 99.5+%
  • Glycine >99.7%
  • Glycine, ACS, 98.5+%
  • Glycine [for Electrophoresis]
  • Aminoacetic Acid (Glycine)
  • Glycine, Aqueous Solution, 25 Kgs/205 Liters
  • GLYCINE extrapure AR
  • Aminoacetic acid, Aminoethanoic acid, Glycocoll
  • Aminoacetic acid, Aminoethanoic acid, Glycinum, Glycocoll
  • aminoacitic acid
  • Glycine, for analysis, 99+% 250GR
  • Aminoacetic Acid Glycocoll H-Gly-OH
  • Glycine, 99%, ACS reagent
  • GLYCINE FOR SYNTHESIS
  • グリシン
  • グリシン [電気泳動用]
  • アミノ酢酸
  • グリココール
  • アミノ酢酸(グリシン)
  • グリシン CRM6022‐A
  • 1 Mグリシン 溶液
  • グリシン (JP17)
  • 電気泳動用試薬
  • 構造分類
  • 生化学
  • α-アミノ酸
  • ω-アミノカルボン酸
  • ω-官能性アルカノール, カルボン酸, アミン & ハライド
  • アミノ酸
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