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コレステロール

コレステロール 化学構造式
57-88-5
CAS番号.
57-88-5
化学名:
コレステロール
别名:
コレステロール;3β-ヒドロキシコレスタ-5-エン;コレステリン;ジトール;コレスタ-5-エン-3-オール;コレステリルアルコール;コレスタ-5-エン-3β-オール;コレステロ-ル;コレステロール CRM6001-A;コレステロル;コレステロール CRM6001‐A;コレステロール標準品;コレステロール 溶液;コレステロール (JP17)
英語化学名:
Cholesterol
英語别名:
Lanol;CHO-HP;Dastar;Dythol;Kathro;Dusoran;Tegolan;Cordulan;Dusoline;Fancol CH
CBNumber:
CB7383339
化学式:
C27H46O
分子量:
386.65
MOL File:
57-88-5.mol

コレステロール 物理性質

融点 :
148-150 °C
比旋光度 :
-36 º (c=2, dioxane)
沸点 :
360 °C
比重(密度) :
1.06
屈折率 :
1.5250 (estimate)
闪点 :
250 °C
貯蔵温度 :
2-8°C
溶解性:
H2O: 0.002 mg/mL
外見 :
powder
色:
white
比重:
1.067
水溶解度 :
negligible
Merck :
14,2201
BRN :
1915888
InChIKey:
HVYWMOMLDIMFJA-DPAQBDIFSA-N
CAS データベース:
57-88-5(CAS DataBase Reference)
NISTの化学物質情報:
Cholesterol(57-88-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  10-48/20/22-40-38-22-36/37/38-67-36/38-20-63
Sフレーズ  24/25-22-36/37-36-26
RIDADR  UN 1170 3/PG 3
WGK Germany  1
RTECS 番号 FZ8400000
TSCA  Yes
HSコード  2906 13 10
国連危険物分類  IRRITANT
有毒物質データの 57-88-5(Hazardous Substances Data)
化審法 (4)-1301
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。

コレステロール 価格 もっと(74)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MPB02101382 コレステロール
CHOLESTEROL
57-88-5 1g ¥9400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MPB02101382 コレステロール
CHOLESTEROL
57-88-5 5g ¥16300 2018-12-26 購入
東京化成工業 C0318 コレステロール >95.0%(GC)
Cholesterol (stabilized with α-Tocopherol) >95.0%(GC)
57-88-5 100g ¥15500 2018-12-04 購入
東京化成工業 C0318 コレステロール >95.0%(GC)
Cholesterol (stabilized with α-Tocopherol) >95.0%(GC)
57-88-5 25g ¥5500 2018-12-04 購入
関東化学株式会社(KANTO) 07331-30 コレステロール
Cholesterol
57-88-5 25g ¥2700 2018-12-13 購入

コレステロール MSDS


3beta-hydroxy-5-cholestene

コレステロール 化学特性,用途語,生産方法

外観

白色~わずかにうすい黄色, 結晶~粉末

定義

本品は、次の化学式で表される有機化合物である。

溶解性

エタノール及びアセトンにやや溶けにくく、水にほとんど溶けない。

用途

有機合成原料、医薬原料、化粧品原料。

用途

化粧品原料、医薬品原料

化粧品の成分用途

非水系増粘剤、皮膚コンディショニング剤、乳化安定剤

効能

乳化剤

純度試験

(1) 溶状 本品0.5gを共栓フラスコにとり,温エタノール (95)50mLに溶かし,室温で2時間放置するとき,混濁又は 沈殿を生じない.
(2) 酸 本品1.0gをフラスコに入れ,ジエチルエーテル 10mLに溶かし,0.1mol/L水酸化ナトリウム液10.0mLを加 えて1分間振り混ぜた後,ジエチルエーテルを留去し,更に 5分間煮沸する.冷後,水10mLを加え,0.05mol/L硫酸で滴 定〈2.50〉する(指示薬:フェノールフタレイン試液2滴).同 様の方法で空試験を行う.
0.1mol/L水酸化ナトリウム液の消費量は0.30mL以下であ る.

乾燥減量

0.30%以下(1g,減圧,60℃,4時間).

説明

Cholesterol is a soft waxy substance that is a steroidal alcohol or sterol. It is the most abundant steroid in the human body and is a component of every cell. Cholesterol is essential to life and most animals and many plants contain this compound. Cholesterol biosynthesis occurs primarily in the liver, but it may be produced in other organs. A number of other substances are synthesized from cholesterol including vitamin D, steroid hormones (including the sex hormones), and bile salts. Cholesterol resides mainly in cell membranes.
Humans produce about 1 gram of cholesterol daily in the liver. Dietary cholesterol is consumed through food. High cholesterol foods are associated with saturated fats and trans-fatty acids (commonly called trans fats). Dietary cholesterol comes from animal products (plants contain minute amounts of cholesterol) such as meats and dairy products.

化学的特性

White to faintly yellow cryst. powder

化学的特性

Cholesterol occurs as white or faintly yellow, almost odorless, pearly leaflets, needles, powder, or granules. On prolonged exposure to light and air, cholesterol acquires a yellow to tan color.

来歴

Cholesterol was discovered in 1769 by Poulletier dela Salle (1719–1787), who isolated the compound from bile and gallstones. It was rediscovered by Michel Eugène Chevreul (1786–1889) in 1815 and named cholesterine. The name comes from the Greek words khole meaning bile and steros meaning solid or stiff . The “ine” ending was later changed to “ol” to designate it as an alcohol.

使用

Cholesterol is commonly associated with cardiovascular disease and its routine measurement is used to measure its potential health risk. High blood serum cholesterol levels are often correlated with excessive plaque deposits in the arteries, a condition known as atherosclerosis or hardening of the arteries. Although high total blood cholesterol levels are associated with heart disease, it is important to distinguish between types of cholesterol when interpreting cholesterol levels. Cholesterol has been labeled as good and bad depending on its physiological role. Forms of cholesterol depend on the lipoproteins that are associated with it. Lowdensity lipoprotein cholesterol (LDL cholesterol) is often referred to as bad cholesterol and high-density lipoprotein (HDL) is identified as good cholesterol. An understanding of the difference between LDL and HDL cholesterol requires an understanding of substances associated with cholesterol in the body. Cholesterol is a lipid so it has very low solubility in water and blood. For the cholesterol synthesized in the liver to be delivered by the bloodstream to the rest of the body, the liver manufactures lipoproteins that can be viewed as carriers for cholesterol (and triglycerides).

使用

cholesterol is a moisturizer and emollient that acts as a powerful emulsifier in water-in-oil systems. Cholesterol is a fat-like substance found in plant and animal cells. It is also present in the secretion of the sebaceous glands and, therefore, is a component of the fat on the skin’s surface. It is considered a noncomedogenic raw material. It may sometimes be obtained from sheep’s wool wax.

使用

analeptic, antibacterial

使用

Cholesterol is a major component of all biological membranes; ~25% of total brain lipid is Cholesterol. Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tis sues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones.

使用

Cholesterol be used as pharmaceutical intermediates and be used as synthetic materials of liquid crystal polymers.

定義

ChEBI: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.

調製方法

The commercial material is normally obtained from the spinal cord of cattle by extraction with petroleum ethers, but it may also be obtained from wool fat. Purification is normally accomplished by repeated bromination. Cholesterol may also be produced by entirely synthetic means.
Cholesterol produced from animal organs will always contain cholestanol and other saturated sterols.

定義

cholesterol: A sterol occurringwidely in animal tissues and also insome higher plants and algae. It canexist as a free sterol or esterified witha long-chain fatty acid. Cholesterol isabsorbed through the intestine ormanufactured in the liver. It servesprincipally as a constituent of bloodplasma lipoproteins and of thelipid–protein complexes that formcell membranes. It is also importantas a precursor of various steroids, especiallythe bile acids, sex hormones,and adrenocorticoid hormones. Thederivative 7-dehydrocholesterol isconverted to vitamin D3 by the actionof sunlight on skin. Increased levelsof dietary and blood cholesterol havebeen associated with atherosclerosis,a condition in which lipids accumulateon the inner walls of arteries andeventually obstruct blood flow.

危険性

Questionable carcinogen.

応用例(製薬)

Cholesterol is used in cosmetics and topical pharmaceutical formulations at concentrations of 0.3–5.0% w/w as an emulsifying agent. It imparts water-absorbing power to an ointment and has emollient activity.
Cholesterol also has a physiological role. It is the major sterol of the higher animals, and it is found in all body tissues, especially in the brain and spinal cord. It is also the main constituent of gallstones.

安全性プロファイル

Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. Used in pharmaceutical and dermal preparations as an emulsifying agent. When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Cholesterol is generally regarded as an essentially nontoxic and nonirritant material at the levels employed as an excipient. It has, however, exhibited experimental teratogenic and reproductive effects, and mutation data have been reported.
Cholesterol is often derived from animal sources and this must be done in accordance with the regulations for human consumption. The risk of bovine spongiform encephalopathy (BSE) contamination has caused some concern over the use of animalderived cholesterol in pharmaceutical products. However, synthetic methods of cholesterol manufacture have been developed.

貯蔵

Cholesterol is stable and should be stored in a well-closed container, protected from light.

純化方法

Crystallise cholesterol from ethyl acetate, EtOH or isopropyl ether/MeOH. [Hiromitsu & Kevan J Am Chem Soc 109 4501 1987.] For extensive details of purification through the dibromide, see Fieser [J Am Chem Soc 75 5421 1953] and Schwenk and Werthessen [Arch Biochem Biophys 40 334 1952], and by repeated crystallisation from acetic acid; see Fieser [J Am Chem Soc 75 4395 1953]. Like many sterols, cholesterol gives colour reactions with conc H2SO4: When cholesterol is dissolved in a small volume of CHCl3 and mixed with conc H2SO4, the colour of the organic layer becomes crimson, then changes to purple and on further standing in air it turns to blue, then green and finally yellow. The H2SO4 layer develops a green fluorescence. [Beilstein 6 III 2607, 6 IV 4000.]

不和合性

Cholesterol is precipitated by digitonin.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (injections; ophthalmic, topical, and vaginal preparations).
Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

コレステロール 上流と下流の製品情報

原材料

準備製品


コレステロール 生産企業

Global( 419)Suppliers
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Kono Chem Co., Ltd
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+86-29-86107037 info@konochemical.com CHINA 2993 58
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57-88-5(コレステロール)キーワード:


  • 57-88-5
  • Δ5-cholesten-3β-ol
  • CHOLESTEROLUM
  • CHOLESTERIN
  • CHOLESTEROL
  • CHOLEST-5-EN-3BETA-OL
  • 5-CHOLESTEN-3BETA-OL
  • (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-DIMETHYL-HEXYL)-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL
  • 3BETA-HYDROXY-5-CHOLESTENE
  • 3beta-hydroxycholest-5-ene
  • 3B-HYDROXY-5-CHOLESTENE
  • 5,6-CHOLESTEN-3-OL
  • SYNTHETIC CHOLESTEROL
  • SYNTHECHOL NSO SUPPLEMENT
  • SYNTHECHOL(TM)
  • CHOLESTEROL XG
  • sterol Cholesterin,Cholest-5-en-3beta-ol
  • 5-Colecten-3-B-ol
  • CHOLESTEROL reference standard grade
  • 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol, Cholesterol
  • SyntheChol(R)
  • Cholesterol solution
  • SyntheChol(R) NS0 Supplement
  • 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol, Cholesterolum
  • 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
  • 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol, Cholesterol, Synthetic cholesterol
  • Cholesterol ,95%
  • Cholesterol,95%,stabilized
  • CHOLESTEROL(SG)
  • CHOLESTEROL CRYST.RESEARCH GRADE
  • Cholesterol, extra pure, Ph Eur, BP, NF, JP
  • コレステロール
  • 3β-ヒドロキシコレスタ-5-エン
  • コレステリン
  • ジトール
  • コレスタ-5-エン-3-オール
  • コレステリルアルコール
  • コレスタ-5-エン-3β-オール
  • コレステロ-ル
  • コレステロール CRM6001-A
  • コレステロル
  • コレステロール CRM6001‐A
  • コレステロール標準品
  • コレステロール 溶液
  • コレステロール (JP17)
  • ステロイド
  • ヒドロキシステロイド
  • 生化学
  • 賦形剤
  • 誘導脂質
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