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コレカルシフェロール

コレカルシフェロール 化学構造式
67-97-0
CAS番号.
67-97-0
化学名:
コレカルシフェロール
别名:
コレカルシフェロール;(5Z,7E)-9,10-セココレスタ-5,7,10(19)-トリエン-3β-オール;オレオビタミンD3;ビタミンD3;活性7-デヒドロコレステロール;コレカルシフェロール標準品;ビタミンD3標準品;デヒドロコレステロール;ビタミン D3;9,10-セコ-5,7,10(19)-コレスタトリエン-3Β-オール;ビタミンD3 , 結晶;ビタミンD3(コレカルシフェロール);ビタミンD3 溶液;ビタミンD3, 99%;コレカルシフェロール (JP17)
英語化学名:
Vitamin D3
英語别名:
WSSD3;Ebivit;Oxarol;Vi-De3;Deparal;rampage;MC 1275;CALCIOL;Prezios;Devaron
CBNumber:
CB6104867
化学式:
C27H44O
分子量:
384.64
MOL File:
67-97-0.mol

コレカルシフェロール 物理性質

融点 :
83-86 °C(lit.)
沸点 :
451.27°C (rough estimate)
比旋光度 :
105 º (c=0.8, EtOH 25 ºC)
比重(密度) :
0.9717 (rough estimate)
蒸気圧:
2.0 x l0-6 Pa (20 °C, est.)
屈折率 :
1.5100 (estimate)
闪点 :
14 °C
貯蔵温度 :
-20°C
溶解性:
Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in trimethylpentane and in fatty oils. It is sensitive to air, heat and light. Solutions in solvents without an antioxidant are unstable and are to be used immediately. A reversible isomerisation to pre-cholecalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds.
外見 :
powder
酸解離定数(Pka):
14.74±0.20(Predicted)
水溶解度 :
<0.1 g/L (20 ºC)
Sensitive :
Air & Light Sensitive
Merck :
14,10019
BRN :
2339331
InChIKey:
QYSXJUFSXHHAJI-YRZJJWOYSA-N
CAS データベース:
67-97-0(CAS DataBase Reference)
NISTの化学物質情報:
Cholecalciferol(67-97-0)
EPAの化学物質情報:
Cholecalciferol (67-97-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,T
Rフレーズ  24/25-26-48/25-23/24/25-20-11-48
Sフレーズ  28-36/37-45-28A-36/37/39-16-7
RIDADR  UN 2811 6.1/PG 2
WGK Germany  2
RTECS 番号 VS2900000
8-10-23
TSCA  Yes
国連危険物分類  6.1
容器等級  II
HSコード  29130000
HSコード  29362990
有毒物質データの 67-97-0(Hazardous Substances Data)
毒性 LD50 oral in rat: 42mg/kg
化審法 (9)-840, (9)-1054
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P284 呼吸用保護具を着用すること。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P310 ただちに医師に連絡すること。
P320 特別な治療が緊急に必要である(このラベ ルの...を見よ)。
P330 口をすすぐこと。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。
P405 施錠して保管すること。

コレカルシフェロール 価格 もっと(45)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSVIT-013N ビタミンD3
Vitamin D3
67-97-0 100mg ¥7400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01AFAB22524 ビタミンD3, 99%
Vitamin D3, 99%
67-97-0 1g ¥12220 2021-03-23 購入
東京化成工業 C0314 コレカルシフェロール >98.0%(HPLC)
Cholecalciferol >98.0%(HPLC)
67-97-0 1g ¥5000 2021-03-23 購入
東京化成工業 C0314 コレカルシフェロール >98.0%(HPLC)
Cholecalciferol >98.0%(HPLC)
67-97-0 5g ¥15400 2021-03-23 購入
関東化学株式会社(KANTO) 08186-96 コレカルシフェロール標準品 >98.5%(HLC)
Cholecalciferol standard >98.5%(HLC)
67-97-0 500mg ¥9000 2021-03-23 購入

コレカルシフェロール MSDS


9,10-Secocholesta-5,7,10(19)-trien-3beta-ol

コレカルシフェロール 化学特性,用途語,生産方法

外観

白色~わずかにうすい黄色, 結晶~結晶性粉末

定義

本品は、ビタミンD3であり、次の化学式で表される。

溶解性

本品は白色の結晶で,においはない.
本品はエタノール(95),クロロホルム,ジエチルエーテル 又はイソオクタンに溶けやすく,水にほとんど溶けない.
本品は空気又は光によって変化する.
融点:84~88℃ 本品を毛細管に入れ,デシケーター(減 圧・2.67kPa以下)で3時間乾燥した後,毛細管を直ちに融封 し,予想した融点の約10℃下の温度に加熱した浴中に入れ, 1分間に3℃上昇するように加熱し,測定する.

用途

くる病治療薬、ダイエットサプリメント、殺鼠剤、ビタミンD欠乏症(くる病,骨軟化症)の治療

用途

ビタミン D3 化合物です。

用途

生理作用研究用。

化粧品の成分用途

皮膚コンディショニング剤

効能

くる病治療薬, ビタミンD受容体作動薬

確認試験

(1) 本品0.5mgをクロロホルム5mLに溶かし,無水酢酸 0.3mL及び硫酸0.1mLを加えて振り混ぜるとき,液は赤色を 呈し,直ちに紫色及び青色を経て緑色に変わる.
(2) 本品につき,赤外吸収スペクトル測定法〈2.25〉の臭 化カリウム錠剤法により試験を行い,本品のスペクトルと本 品の参照スペクトル又はコレカルシフェロール標準品のスペ クトルを比較するとき,両者のスペクトルは同一波数のとこ ろに同様の強度の吸収を認める.

定量法

本操作はできるだけ空気又は酸化剤との接触を避け, 遮光容器を用いて行う.本品及びコレカルシフェロール標準 品約30mgずつを精密に量り,それぞれイソオクタンに溶か し,正確に50mLとする.この液10mLずつを正確に量り, それぞれに内標準溶液3mLを正確に加えた後,移動相を加 えて50mLとし,試料溶液及び標準溶液とする.試料溶液及 び標準溶液10μLにつき,次の条件で液体クロマトグラフィ ー〈2.01〉により試験を行い,内標準物質のピーク面積に対 するコレカルシフェロールのピーク面積の比Q T及びQ Sを求 める.
コレカルシフェロール(C27H44O)の量(mg)=MS × Q T/Q S
MS:コレカルシフェロール標準品の秤取量(mg)
内標準溶液 フタル酸ジメチルのイソオクタン溶液(1→ 100)

純度試験

7-デヒドロコレステロール 本品10mgを薄めた エタノール(9→10)2.0mLに溶かし,ジギトニン20mgを薄め たエタノール(9→10)2.0mLに溶かした液を加え,18時間放 置するとき,沈殿を生じない.

使用上の注意

不活性ガス封入

化学的特性

White or colorless crystalline solid. Odorless;

Originator

Vitamin D, Country Life

使用

Cholecalciferol and ergocalciferol are used for the control of rats and mice.

使用

Vitamin D3 analogue.

使用

carnitine replenisher in peripheral arterial disease

使用

The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that i s a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects o n breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

使用

selective phosphodiesterase-4 inhibitor (PDE-4 inhibitor) under investigation for treating respiratory diseases involving chronic inflammation such as asthma or COPD (smoker’s lung)

定義

A free vitamin D 3, isolated in crystalline state from the 3,5-dinitrobenzoate, produced by irradiation, and equivalent in activity to vitamin D3 of tunaliver oil.

適応症

Vitamin D is the collective term for a group of compounds formed by the action of ultraviolet irradiation on sterols. Cholecalciferol (vitamin D3) and calciferol (vitamin D2) are formed by irradiation of the provitamins 7- dehydrocholesterol and ergosterol, respectively. The conversion to vitamin D3 occurs in the skin. The liver is the principal storage site for vitamin D, and it is here that the vitamin is hydroxylated to form 25-hydroxyvitamin D. Additional hydroxylation to form 1,25-dihydroxyvitamin D occurs in the kidney in response to the need for calcium and phosphate

適応症

Vitamin D3, through its active metabolite, 1,25- (OH)2D3, also plays an important role in maintaining calcium homeostasis by enhancing intestinal calcium absorption, PTH-induced mobilization of calcium from bone, and calcium reabsorption in the kidney.

Manufacturing Process

5 g of 7-dehydrocholesteryl acetate (prepared by W.R. Ness, R. S. Kostic and Mosetting, J. Am. Chem. Soc. 78, 436, 1956) were dissolved in 500 ml of nhexane. This solution was irradiated with ultraviolet ray by recyclicly passing it through a quartz apparatus surrounding 450 w high pressure mercury vapor lamps for 80 minutes. After irradiation and then the distillating off of nhexane the solution was added with 50 ml of ethanol and the ethanolic solution was left to stand overnight at the temperature of -20°C. The formed crystals were filtered off from ethanolic solution and filtrate was heated at the temperature 78°C for 4 hours. After cooling of filtrate, the cooled filtrate was added with 4 ml of ethanolic solution containing 0.7 g of potassium hydroxide to effect a reaction at the temperature of 20°C and under nitrogen for 60 minutes. The reaction product was added with 0.7 ml glacial acetic acid and then ethanol was distilled off under reduced pressure from the reaction product. The obtained residue was extracted with 50 ml of n-hexane and extract was washed with water and n-hexane was distilled off from extract to obtain 2.5 g of yellow oily matter containing vitamin D3. The content of vitamin D3 in yellow oily matter was 40.2% by weight.

Therapeutic Function

Vitamin, Antirachitic

生合成

The primary supply of vitamin D3 in humans is not obtained from the diet but rather is derived from the ultraviolet photoconversion of 7-dehydrocholesterol to vitamin D3 in skin. Thus, vitamin D3 synthesis varies with the seasons. D3 is a prohormone and requires further metabolic conversion to exert biological activity in its target organs. The liver and the kidney are the major sites of metabolic activation of this endogenous sterol hormone. The initial transformation of D3 occurs in the liver and is catalyzed by the enzyme 25-OH-D3-hydroxylase to form 25-(OH)D3; this is the primary circulating form of D3. Circulating 25-(OH)D3 is then converted by the kidney to the most active form of D3, 1,25-(OH)2D3, by the 1-(OH)-D3-hydroxylase enzyme. Blood concentrations of 1,25-(OH)2D3 are approximately one fivehundredth of those of 25-(OH)D3. 1, 25-(OH)2D3 is converted to the metabolite 24R,25-(OH)2D3, which is capable of suppressing parathyroid secretion.
In addition to the endogenous metabolites, some exogenous sterols possess biological activity similar to that of D3. Ergocalciferol (vitamin D2) is derived from the plant sterol ergosterol and may act as a substrate for both the 25-hydroxylase and the 1-hydroxylase enzyme systems of the liver and kidney to form 25-(OH)D2 and 1,25-(OH)2 D2, respectively. Ergocalciferol (vitamin D2) is the form used in commercial vitamins and supplemented dairy products. Dihydrotachysterol, another sterol that is used as a therapeutic agent, also functions as a substrate for the hydroxylase enzymes in the liver and kidney.

一般的な説明

Fine colorless crystals. Water insoluble.

空気と水の反応

Sensitive to moisture, air and light. . Water insoluble.

反応プロフィール

Vitamin D3 may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.

健康ハザード

SYMPTOMS: Symptoms of exposure to Vitamin D3 may include weakness, fatigue, lassitude headache, nausea, vomiting, diarrhea, polyuria, polydipsia, nocturia, decrease urinary concentrating ability, proteinuria, tissue calcification, hypertension and osteoporosis.

火災危険

Flash point data for Vitamin D3 are not available. Vitamin D3 is probably combustible.

农业用途

Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries. Registered for use in the U.S. and other countries.

製品名

DELSTEROL®; DEPARAL®; D3- VIGANTOL®; QUINTOX®; RAMPAGE®; RICKETON®; TRIVITAN®; VIGORSAN®; VITINC DAN-DEE-3®

作用機序

1, 25-(OH)2D3 exerts its influence within target tissues through high-affinity sterol-specific intracellular receptor proteins.The D3 receptor, similar to steroid receptor systems, translocates the hormone from the cell cytoplasm to the nucleus, where biological response is initiated via transcription and translation.

臨床応用

The principal disorder associated with inadequate vitamin D intake is rickets. The low blood calcium and phosphate levels that occur during vitamin D deficiency stimulate parathyroid hormone secretion to restore calcium levels. In children, this deficiency leads to the formation of soft bones that become deformed easily; in adults, osteomalacia results from the removal of calcium from the bone.Vitamin D deficiency may occur in patients with metabolic disorders, such as hypoparathyroidism and renal osteodystrophy. The requirement for vitamin D is slightly higher in members of darker-pigmented races, since melanin interferes with the irradiation that produces vitamin D3 in the skin. People with limited exposure to the sun may need to supplement vitamin D intake.

副作用

The hypercalcemia resulting from hypervitaminosis D is responsible for toxic symptoms such as muscle weakness, bone pain, anorexia, ectopic calcification, hypertension, and cardiac arrhythmias. Toxicity in infants can result in mental and physical retardation, renal failure, and death.

安全性プロファイル

Poison by ingestion. An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

職業ばく露

Sterol rodenticide used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries

代謝経路

Cholecalciferol (vitamin D3) is the mammalian form of vitamin D. It is normally produced in the skin by the action of UV light on its precursor, 7- dehydrocholesterol. Essential amounts of the vitamin are obtained thus or from dietary sources such as fish oils. The active form of the vitamin is 1,25-dihydroxy-cholecalciferol. Its formation occurs in two stages: 25- hydroxylation in the liver, followed by 1-hydroxylation in the kidney (see Engstrom and Koszewski, 1989 and references cited therein).

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

純化方法

It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 III 2811, 6 IV 4149.]

Degradation

It is unstable in light and air and in acidic media. It is inactivated within a few days under normal exposure conditions. This is due to oxidation and fragmentation of the triene functionality.

Toxicity evaluation

Another steroidal rodenticide is cholecalciferol, which is in fact the naturally occurring vitamin D3. This compound is an essential factor for vertebrates but in large doses causes hypercalcemia, resulting in calcification and degeneration of various soft tissues, ultimately leading to death. In baits, cholecalciferol may be combined with other, usually anticoagulant, rodenticides. The main natural source of cholecalciferol is fish liver oil, but it is manufactured from ergosterol.

不和合性

Sensitive to air, light, and moisture. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

廃棄物の処理

Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

コレカルシフェロール 上流と下流の製品情報

原材料

準備製品


コレカルシフェロール 生産企業

Global( 514)Suppliers
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67-97-0(コレカルシフェロール)キーワード:


  • 67-97-0
  • Vitamin D3 solution
  • Vitamin D3-d3 Cholecalciferol (6,19,19-d3)
  • Cholecalciferol d6
  • Vitamin D3-d6
  • 10-Secocholesta-5,7,10(19)-trien-
  • (5Z,7E,3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
  • 3Z-[2E-[(1R,3aS,7aR)-1S-[1R,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol
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  • CHOLECALCIFEROL, PH EUR
  • CHOLECALCIFEROL CRYSTALLINE
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  • VITAMIN D3 99+%
  • VitaminD3(Cholecalciferol40000Iu)
  • VitaminD3MedicalGrade
  • VitaminD2MedicalGrade
  • VitaminD3CrystalPowder(40,000,000Iu)
  • Cholecalciferol/VitamineD3
  • VitaminD3U.S.P.
  • VitaminD/VitaminD3
  • cholecalciferol,d3
  • d3-vicotrat
  • D3-Vigantol
  • Delsterol
  • Deparal
  • duphafrald31000
  • Ebivit
  • Micro-dee
  • neodohyfrald3
  • Provitina
  • rampage
  • コレカルシフェロール
  • (5Z,7E)-9,10-セココレスタ-5,7,10(19)-トリエン-3β-オール
  • オレオビタミンD3
  • ビタミンD3
  • 活性7-デヒドロコレステロール
  • コレカルシフェロール標準品
  • ビタミンD3標準品
  • デヒドロコレステロール
  • ビタミン D3
  • 9,10-セコ-5,7,10(19)-コレスタトリエン-3Β-オール
  • ビタミンD3 , 結晶
  • ビタミンD3(コレカルシフェロール)
  • ビタミンD3 溶液
  • ビタミンD3, 99%
  • コレカルシフェロール (JP17)
  • ビタミン
  • 生化学
  • 殺鼠剤
  • 誘導脂質
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