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スルファメサジン

スルファメサジン 化学構造式
57-68-1
CAS番号.
57-68-1
化学名:
スルファメサジン
别名:
スルファメサジン;スルホジメジン;スルファジン;ベルトラン;ジメザチン;スルファメタジン;スルファミジン;クレモメタジン;4-アミノ-N-(4,6-ジメチル-2-ピリミジニル)ベンゼンスルホンアミド;スルファジメシン;スルファジメジン;ネアジナ;スルファジミジン;N-(4,6-ジメチルピリミジン-2-イル)-4-アミノベンゼンスルホンアミド;アゾルメタジン;スーパーセプチル;スルファジメラジン;4-アミノ-N-(4,6-ジメチルピリミジン-2-イル)ベンゼンスルホンアミド;スパンボレート;ピルマジン
英語化学名:
Sulfamethazine
英語别名:
SM2;L-30;A-502;saiii;S-Mez;Diazi;bn2409;Diazil;Sa III;Mermeth
CBNumber:
CB8116727
化学式:
C12H14N4O2S
分子量:
278.33
MOL File:
57-68-1.mol

スルファメサジン 物理性質

融点 :
197 °C
沸点 :
294°C (rough estimate)
比重(密度) :
1.2997 (rough estimate)
屈折率 :
1.6440 (estimate)
貯蔵温度 :
2-8°C
溶解性:
acetone: soluble50mg/mL
外見 :
Crystalline Powder
酸解離定数(Pka):
7.4, 2.65(at 25℃)
色:
white to off-white
水溶解度 :
150mg/100mL (29 ºC)
Merck :
14,8905
BRN :
261304
安定性::
Stable, but light sensitive. Incompatible with strong oxidizing agents.
CAS データベース:
57-68-1(CAS DataBase Reference)
NISTの化学物質情報:
Sulfamethazine(57-68-1)
IARC:
3 (Vol. 79) 2001
EPAの化学物質情報:
Sulfamethazine (57-68-1)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  23-24/25-36-26
WGK Germany  2
RTECS 番号 WO9275000
10
TSCA  Yes
HSコード  29350090
有毒物質データの 57-68-1(Hazardous Substances Data)
毒性 LD50 i.p. in mice: 1.06 g/kg (Bobranski)
化審法 一般化学物質

スルファメサジン 価格 もっと(27)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA19276 スルファメサジン, 99%
Sulfamethazine, 99%
57-68-1 25g ¥4280 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC510096
Sulfamethazine
57-68-1 1g ¥6300 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01AFAA19276 スルファメサジン, 99%
Sulfamethazine, 99%
57-68-1 100g ¥12760 2021-03-23 購入
東京化成工業 S0586 スルファメサジン >98.0%(HPLC)(T)
Sulfamethazine >98.0%(HPLC)(T)
57-68-1 250g ¥15500 2021-03-23 購入
東京化成工業 S0586 スルファメサジン >98.0%(HPLC)(T)
Sulfamethazine >98.0%(HPLC)(T)
57-68-1 25g ¥2400 2021-03-23 購入

スルファメサジン 化学特性,用途語,生産方法

外観

白色~うすい黄色, 結晶~粉末

溶解性

水酸化ナトリウム溶液に溶ける。

用途

動物用医薬品定量用の標準品。

効能

抗菌薬, 葉酸合成阻害薬

化学的特性

White to Off-Solid

Originator

Cremomethazine,MSD,US,1947

使用

Antibacterial

定義

ChEBI: A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.

Manufacturing Process

A flask heated in an oil bath is filled with 600 ml water and 60 g (1 mol) glacial acetic acid (or an equivalent quantity of diluted acetic acid). While stirring 235 g (1.1 mols) anhydrous p-aminobenzenesulfonamidoguanidine (or an equivalent quantity of a nonanhydrous product) and 122 g (1 mol) sodium acetylacetonate 100% purity (or an equivalent quantity of product of a lower purity) are introduced into the flask while stirring.
The temperature of the reaction mixture is brought to 102°C to 103°C, the mixture is further stirred at this temperature during 24 hours. The pH value of the mixture, which should range between 5 and 6 is checked during the reaction.
On expiry of the reaction period heating is cut off, the mass being cooled or allowed to cool down to 60°C.
Filtering under suction is effected, the solids on the filter being washed with 100 ml water at 80°C.
After drying of the product on the filter 256 g of 2-paminobenzenesulfonamido- 4,6-dimethylpyrimidine, melting point 196°C to 197°C, purity 99.5% are obtained. The output is 92% of the theory calculated with respect to the sodium acetylacetonate employed.

brand name

Calfspan Tablets [Veterinary] (Fort Dodge Animal Health); Sulka S Boluses [Veterinary] (Fort Dodge Animal Health); SulfaSURE SR Bolus [Veterinary] (Boehringer Ingelheim Animal Health);Crermomethazine;Deladine;Dimezathine;Hava-span;Intradin;Neotrizine;Rigesol;Rivodin;S-dimidine;Spanbolet;Sulka-s;Sulphamezathine;Sulphfmezatine;Superseptyl;Sustain iii;Tersulpha;Trisulfaminic;Trisulfaminie.

Therapeutic Function

Antimicrobial

世界保健機関(WHO)

Sulfadimidine, a sulfonamide anti-infective agent, was introduced in 1942 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfadimidine is still used in some countries as a injectable or oral antimicrobial for susceptible infections.

抗菌性

This drug is used for pneumococcal, staphylococcal, and streptococcal infections as well as for sepsis, gonorrhea, and other infectious diseases. Synonyms of this drug are sulfadiamezin and sulfadimidin.

一般的な説明

Sulfamethazine’splasma half-life is 7 hours. This compound is similar inchemical properties to sulfamerazine and sulfadiazine butdoes have greater water solubility than either. Its pKa is 7.2.Because it is more soluble in acid urine than sulfamerazineis, the possibility of kidney damage from use of the drug isdecreased. The human body appears to handle the drugunpredictably; hence, there is some disfavor to its use in thiscountry except in combination sulfa therapy (in trisulfapyrimidines,USP) and in veterinary medicine.

一般的な説明

Odorless sticky, white or creamy-white crystalline powder. Slightly bitter taste. An antibacterial.

空気と水の反応

Water solubility increases rapidly with increasing pH [Merck]. Insoluble in water.

反応プロフィール

Sulfamethazine is sensitive to light and may also be sensitive to heat. The presence of oxygen and moisture may accelerate the effects of heat and light .

火災危険

Flash point data for Sulfamethazine are not available; however, Sulfamethazine is probably combustible.

応用例(製薬)

2-Sulfanilamido-4,6-methylpyrimidine (syn: sulphamethazine, sulfamezathine). A water-soluble compound, unstable on exposure to light. It is usually administered by mouth and is a component of some triple sulfonamide combinations.
The spectrum is typical of the group, but sulfadimidine exhibits relatively low potency. It is well absorbed after oral administration. It is extensively metabolized, predominantly by acetylation. The mean plasma half-life (1.5–5 h) varies with acetylator status.
In addition to side effects common to the group, a serious interaction between ciclosporin (cyclosporin A) and sulfadimidine, leading to reduced ciclosporin levels, has been reported.

安全性プロファイル

Moderately toxic by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Chemical Synthesis

Sulfamethazine, N1 -(4,6-dimethyl-2-pyrimidinyl)sulfanilamide (33.1.13), is also synthesized in the aforementioned manner by reacting 4-acetylaminobenzenesulfonyl chloride with 2-amino-4,6-dimethylpyrimidine, which is in turn synthesized by condensing acetylacetone with guanidine followed by hydrolysis of the acetylamino group using a base.

純化方法

Crystallise it from dioxane or aqueous dioxane. [Caldwell et al. J Am Chem Soc 63 2188 1941, Roblin et al. J Am Chem Soc 64 567 1942, Beilstein 25 III/IV 2215.]

スルファメサジン 上流と下流の製品情報

原材料

準備製品


スルファメサジン 生産企業

Global( 376)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
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Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58

57-68-1(スルファメサジン)キーワード:


  • 57-68-1
  • (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
  • 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • 6-(4’-aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
  • 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
  • A-502
  • Azolmetazin
  • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • benzenesulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimiidinyl)-
  • Benzensulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • bn2409
  • Calfspan tablets
  • Cremomethazine
  • Diazil
  • Diazilsulfadine
  • Dimezathine
  • Dimidim-R
  • Dimidin-R
  • Hava-Span
  • Intradine
  • Kelametazine
  • L-30
  • Mermeth
  • Metazin
  • n(1)-(4,6-dimethyl-2-pyrimidinyl)-sulfanilamid
  • n(1)-(4,6-dimethyl-2-pyrimidyl)sulfanilamide
  • N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • N(sup1)-(2,6-Dimethylpyrimid-4-yl)sulfanilamide
  • Sulfodimezine
  • Sulka k boluses
  • Sulphadimethylpyrimidine
  • スルファメサジン
  • スルホジメジン
  • スルファジン
  • ベルトラン
  • ジメザチン
  • スルファメタジン
  • スルファミジン
  • クレモメタジン
  • 4-アミノ-N-(4,6-ジメチル-2-ピリミジニル)ベンゼンスルホンアミド
  • スルファジメシン
  • スルファジメジン
  • ネアジナ
  • スルファジミジン
  • N-(4,6-ジメチルピリミジン-2-イル)-4-アミノベンゼンスルホンアミド
  • アゾルメタジン
  • スーパーセプチル
  • スルファジメラジン
  • 4-アミノ-N-(4,6-ジメチルピリミジン-2-イル)ベンゼンスルホンアミド
  • スパンボレート
  • ピルマジン
  • N-(4,6-ジメチル-2-ピリミジニル)-p-アミノベンゼンスルホンアミド
  • スルファジメチルピリミジン
  • N-(4,6-ジメチル-2-ピリミジニル)-4-アミノベンゼンスルホンアミド
  • ダイアジル
  • スルファジミジン標準品
  • スルファメタジン標準品
  • 4,6-ジメチルスルファジアジン
  • スルファジミジンスルファミジンスルファメタジンスルファジメチルピリミジン
  • スルファメサジン, 99%
  • 合成抗菌剤
  • 生化学
  • 試験研究用抗菌剤
  • サルファ剤 (試験研究用合成抗菌剤)
  • サルファ剤
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