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ジメチル硫酸

ジメチル硫酸 化学構造式
77-78-1
CAS番号.
77-78-1
化学名:
ジメチル硫酸
别名:
ジメチル硫酸;ジメチル=スルファート;硫酸ジメチル;メチルスルファート;硫酸メチル;メタンスルファート;硫酸ジメチル(ジメチル硫酸);硫酸ジメチル, 1000 µg/mL in AcCN
英語化学名:
Dimethyl sulfate
英語别名:
NSC 56194;ai3-52118;Methanesulfate;METHYL SULFATE;Dimethylsulfat;Dimetilsolfato;Methylsulphate;Dimethylsulfaat;DIMETHYL SULFATE;sulfatedemethyle
CBNumber:
CB9854316
化学式:
C2H6O4S
分子量:
126.13
MOL File:
77-78-1.mol

ジメチル硫酸 物理性質

融点 :
-32 °C
沸点 :
188 °C(lit.)
比重(密度) :
1.333 g/mL at 25 °C(lit.)
蒸気密度:
4.3 (vs air)
蒸気圧:
0.7 mm Hg ( 25 °C)
屈折率 :
n20/D 1.386(lit.)
闪点 :
182 °F
貯蔵温度 :
2-8°C
溶解性:
ethanol: 0.26 g/mL, clear, colorless
外見 :
Liquid
色:
Clear colorless
臭い (Odor):
Almost odorless
水溶解度 :
2.8 g/100 mL (18 ºC)
Merck :
13,3282
BRN :
635994
暴露限界値:
TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
安定性::
Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
CAS データベース:
77-78-1(CAS DataBase Reference)
IARC:
2A (Vol. 4, Sup 7, 71) 1999
NISTの化学物質情報:
Sulfuric acid, dimethyl ester(77-78-1)
EPAの化学物質情報:
Dimethyl sulfate (77-78-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+
Rフレーズ  45-25-26-34-43-68
Sフレーズ  53-45-61
RIDADR  UN 1595 6.1/PG 1
WGK Germany  2
RTECS 番号 WS8225000
21
自然発火温度 495 °C
国連危険物分類  6.1(a)
容器等級  I
HSコード  29209090
有毒物質データの 77-78-1(Hazardous Substances Data)
毒性 LD50 orally in rats: 440 mg/kg (Smyth)
消防法 危-4-3-III
化審法 (2)-1673 優先評価化学物質
安衛法 特化則 特定化学物質(特定第2類) 変異原性物質
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H341 遺伝性疾患のおそれの疑い 生殖細胞変異原性 2 警告 P201,P202, P281, P308+P313, P405,P501
H350 発がんのおそれ 発がん性 1A, 1B 危険
注意書き
P201 使用前に取扱説明書を入手すること。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。

ジメチル硫酸 価格 もっと(14)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0104-0891 硫酸ジメチル 95.0+% (Titration)
Dimethyl Sulfate 95.0+% (Titration)
77-78-1 25g ¥2550 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01ACSAS-E0389 硫酸ジメチル
Dimethyl sulfate, 1000 ug/mL in AcCN
77-78-1 1mL ¥11800 2021-03-23 購入
東京化成工業 D0797 ジメチル硫酸 >98.0%(GC)
Dimethyl Sulfate >98.0%(GC)
77-78-1 25g ¥1900 2021-03-23 購入
東京化成工業 D0797 ジメチル硫酸 >98.0%(GC)
Dimethyl Sulfate >98.0%(GC)
77-78-1 500g ¥2900 2021-03-23 購入
関東化学株式会社(KANTO) 10376-01 硫酸ジメチル(ジメチル硫酸)
Dimethyl sulfate
77-78-1 500mL ¥6500 2021-03-23 購入

ジメチル硫酸 MSDS


Dimethyl sulfate

ジメチル硫酸 化学特性,用途語,生産方法

外観

無色〜うすい黄色, 澄明の液体

溶解性

水と反応。エタノール, エーテル, アセトンと混和。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

解説

(CH3O)2SO2(126.13).ジメチル硫酸ともいう.メチルアルコールあるいはジメチルエーテルと発煙硫酸から得られる.無色の油状の液体.融点-27 ℃,沸点188 ℃,76 ℃(2 kPa).d201.3322.n204 1.3874.もっとも効果的なメチル化剤の一種である.毒性が強く,皮膚から吸収され,壊死を起こし,粘膜,とくに呼吸器粘膜の炎症を起こす.腎臓,肝臓,心臓もおかされる.LD50 205 mg/kg(ラット,経口).[CAS 77-78-1]
森北出版「化学辞典(第2版)

用途

合成剤、溶剤、安定剤

用途

有機合成のメチル化剤、中間物アニソール、香料ネロリンの合成、医薬品(ピリン剤、カフェイン、ビタミン等)の合成、メチルハイドロキノンやポリメチシアニン染料、メチルセルロースの製造、芳香族炭化水素の抽出用溶剤、安定剤(無水硫酸、ジシアノエチレンモノマー)

説明

Dimethyl sulfate is a colorless, oily liquid with a faint, onionlike odor. It is soluble in water, ether, dioxane, acetone, benzene, and other aromatic hydrocarbons, miscible with ethanol, and sparingly soluble in carbon disulfide. It is stable under normal temperatures and pressures, but hydrolyzes rapidly in water at or above 18 ℃.
Dimethyl sulfate has been produced commercially since at least the 1920s. One production method is continuous reaction of dimethyl ether with sulfur trioxide. In 2009, dimethyl sulfate was produced by 33 manufacturers worldwide, including 1 in the United States, 14 in China, 5 in India, 5 in Europe, 6 in East Asia, and 2 in Mexico, and was available from 44 suppliers, including 16 US suppliers. There are no data on US imports or exports of dimethyl sulfate. Reports filed from 1986 through 2002 under the US Environmental Protection Agency’s Toxic Substances Control Act Inventory Update Rule indicate that US production plus imports of dimethyl sulfate totaled 10–50 million pounds. The simplest way of synthesizing dimethyl sulfate is by esterification of sulfuric acid with methanol as follows:2CH3OH+ H2SO4→(CH3)2SO4 + 2H2O

化学的特性

Dimethyl sulfate is essentially odorless. The specific gravity of this colorless, corrosive, oily liquid is 1.3322 g/cm3. Dimethyl sulfate is soluble in ether, dioxane, acetone, benzene, and other aromatic hydrocarbons. It is sparingly soluble in carbon disulfide and aliphatic hydrocarbons, and only slightly soluble in water (28 g/l at 18 °C) (O'Neil, 2006).

使用

Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions

使用

Diethyl sulfate is used as an ethylating agentin many organic syntheses. It is also usedas an accelerator in the sulfation of ethyleneand as an intermediate in certain sulfonationreactions (Merck 1996).

使用

It is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.

定義

ChEBI: The dimethyl ester of sulfuric acid.

製造方法

Dimethyl sulfate is prepared by distillation of an oleum/methanol mixture; technical production using dimethyl ether and SO3 has also been reported (NLM, 2013).

一般的な説明

Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.

空気と水の反応

Water soluble.

反応プロフィール

Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].

健康ハザード

Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.

燃焼性と爆発性

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

化学反応性

Reactivity with Water Slow, non-hazardous reaction; Reactivity with Common Materials: Corrodes metal when wet; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Sodium bicarbonate or lime; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

安全性プロファイル

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.

Carcinogenicity

Dimethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

環境運命予測

Chemical/Physical. Hydrolyzes in water (half-life = 1.2 h) to methanol and sulfuric acid (Robertson and Sugamori, 1966) via the intermediate methyl sulfuric acid (Du Pont, 1999a)

貯蔵

work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.

不和合性

Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.

廃棄物の処理

Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.

ジメチル硫酸 上流と下流の製品情報

原材料

準備製品


ジメチル硫酸 生産企業

Global( 260)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Cangzhou Wanyou New Material Technology Co.,Ltd
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HENAN BON INDUSTRIAL CO.,LTD
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77-78-1(ジメチル硫酸)キーワード:


  • 77-78-1
  • DIMETHYLSULFATE,REAGENT
  • Dimethylsulfate,98%
  • DIMETHYL SULFATE 99 % MIN.
  • DIMETHYL SULFATE MOLECULAR BIOLOGY*REAGE NT
  • DIMETHYL SULFATE 99+%
  • Dimethylsulphate99%
  • DIMETHYL SULFATE[FOR ACETAMIPRID]
  • Dimethylsulfate (chemical production)
  • Dimethyl sulfuric acid
  • Sulfuric acid dimethyl
  • Methanesulfate
  • Dimethyl sulfateMethyl sulfate
  • Dimethyl sulfate, synthesis grade
  • NSC 56194
  • DiMethyl sulfate, 99+%, AcroSeal
  • DIMETHYL SULFATE FOR SYNTHESIS
  • METHYL SULFATE
  • DIMETHYL SULPHATE
  • DIMETHYL SULFATE
  • AKOS BBS-00004221
  • SULFURIC ACID DIMETHYL ESTER
  • SULPHURIC ACID DIMETHYL ESTER
  • dimethylesterkyselinysirove
  • dimethylesterkyselinysirove(czech)
  • dimethylmonosulfate
  • Dimethylsulfaat
  • Dimethylsulfat
  • dimethylsulfat(czech)
  • Dimetilsolfato
  • DMS (Methyl sulfate)
  • ジメチル硫酸
  • ジメチル=スルファート
  • 硫酸ジメチル
  • メチルスルファート
  • 硫酸メチル
  • メタンスルファート
  • 硫酸ジメチル(ジメチル硫酸)
  • 硫酸ジメチル, 1000 µg/mL in AcCN
  • その他(硫黄化合物(合成用))
  • 硫黄化合物 (合成用)
  • 有機合成化学
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