설파메타진
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설파메타진 속성
- 녹는점
- 197 °C
- 끓는 점
- 294°C (rough estimate)
- 밀도
- 1.2997 (rough estimate)
- 굴절률
- 1.6440 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 아세톤: 가용성50mg/mL
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 7.4, 2.65(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 150mg/100mL(29ºC)
- Merck
- 14,8905
- BRN
- 261304
- 안정성
- 안정적이지만 빛에 민감합니다. 강한 산화제와 호환되지 않습니다.
- CAS 데이터베이스
- 57-68-1(CAS DataBase Reference)
- IARC
- 3 (Vol. 79) 2001
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 23-24/25-36-26 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WO9275000 | ||
F 고인화성물질 | 10 | ||
TSCA | Yes | ||
HS 번호 | 29350090 | ||
유해 물질 데이터 | 57-68-1(Hazardous Substances Data) | ||
독성 | LD50 i.p. in mice: 1.06 g/kg (Bobranski) | ||
기존화학 물질 | KE-01321 |
설파메타진 C화학적 특성, 용도, 생산
개요
Sulfamethazine is an antibacterial sulfonamide. Like other sulfonamides, sulfamethazine is bacteriostatic, competitively inhibiting dihydropteroate synthase to block folate synthesis and inhibit growth and multiplication. Sulfamethazine is metabolized by cytochrome P450 isoforms and arylamine N-acetyltransferase 2 in a sex-dependent manner.화학적 성질
White to Off-Solid용도
Sulfamethazine is an antibacterial.This compound is a contaminant of emerging concern (CECs).정의
ChEBI: A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.World Health Organization (WHO)
Sulfadimidine, a sulfonamide anti-infective agent, was introduced in 1942 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfadimidine is still used in some countries as a injectable or oral antimicrobial for susceptible infections.Antimicrobial activity
This drug is used for pneumococcal, staphylococcal, and streptococcal infections as well as for sepsis, gonorrhea, and other infectious diseases. Synonyms of this drug are sulfadiamezin and sulfadimidin.일반 설명
Sulfamethazine’splasma half-life is 7 hours. This compound is similar inchemical properties to sulfamerazine and sulfadiazine butdoes have greater water solubility than either. Its pKa is 7.2.Because it is more soluble in acid urine than sulfamerazineis, the possibility of kidney damage from use of the drug isdecreased. The human body appears to handle the drugunpredictably; hence, there is some disfavor to its use in thiscountry except in combination sulfa therapy (in trisulfapyrimidines,USP) and in veterinary medicine.공기와 물의 반응
Water solubility increases rapidly with increasing pH [Merck]. Insoluble in water.반응 프로필
Sulfamethazine is sensitive to light and may also be sensitive to heat. The presence of oxygen and moisture may accelerate the effects of heat and light .화재위험
Flash point data for Sulfamethazine are not available; however, Sulfamethazine is probably combustible.Pharmaceutical Applications
2-Sulfanilamido-4,6-methylpyrimidine (syn: sulphamethazine, sulfamezathine). A water-soluble compound, unstable on exposure to light. It is usually administered by mouth and is a component of some triple sulfonamide combinations.The spectrum is typical of the group, but sulfadimidine exhibits relatively low potency. It is well absorbed after oral administration. It is extensively metabolized, predominantly by acetylation. The mean plasma half-life (1.5–5 h) varies with acetylator status.
In addition to side effects common to the group, a serious interaction between ciclosporin (cyclosporin A) and sulfadimidine, leading to reduced ciclosporin levels, has been reported.
Safety Profile
Moderately toxic by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of SOx and NOx.Purification Methods
Crystallise it from dioxane or aqueous dioxane. [Caldwell et al. J Am Chem Soc 63 2188 1941, Roblin et al. J Am Chem Soc 64 567 1942, Beilstein 25 III/IV 2215.]설파메타진 준비 용품 및 원자재
원자재
준비 용품
설파메타진 공급 업체
글로벌( 539)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 893 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +8618239973690 |
sales@suikangpharm.com | China | 178 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 476 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |