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1,1,1,2-テトラフルオロエタン

1,1,1,2-テトラフルオロエタン 化学構造式
811-97-2
CAS番号.
811-97-2
化学名:
1,1,1,2-テトラフルオロエタン
别名:
1,1,1,2-テトラフルオロエタン;ノルフルラン;1,2,2,2-テトラフルオロエタン;フレオン134a;フロン134a;1,1,1,2テトラフルオロエタン;1,1,1,2- テトラフルオロエタン (HFC-134a) ;1,1,1,2-テトラフルオロエタン、;1,1,1,2‐テトラフルオロエタン;FREON #134A (200 ΜG/ML IN MEOH)
英語化学名:
1,1,1,2-Tetrafluoroethane
英語别名:
R134A;HC134a;AK134a;CF3CH2F;FC-134A;CFC134A;DF-134a;CH2FCF3;HFA-134a;SUVA134a
CBNumber:
CB8323060
化学式:
C2H2F4
分子量:
102.03
MOL File:
811-97-2.mol

1,1,1,2-テトラフルオロエタン 物理性質

融点 :
-101°C
沸点 :
−26.5 °C(lit.)
比重(密度) :
1.21
屈折率 :
1.0007
溶解性:
Soluble in ethanol (95%), ether, and 1 in 1294 parts of water at 20℃.
Merck :
13,4734
安定性::
Stable. May cause damage to the atmosphere. Incompatible with active metals, strong oxidizing agents.
InChIKey:
LVGUZGTVOIAKKC-UHFFFAOYSA-N
CAS データベース:
811-97-2(CAS DataBase Reference)
NISTの化学物質情報:
Ethane, 1,1,1,2-tetrafluoro-(811-97-2)
EPAの化学物質情報:
Ethane, 1,1,1,2-tetrafluoro-(811-97-2)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Sフレーズ  23-38
RIDADR  UN 3159 2.2
WGK Germany  1
RTECS 番号 KI8842500
Hazard Note  Irritant
TSCA  T
国連危険物分類  2.2
有毒物質データの 811-97-2(Hazardous Substances Data)
毒性 LC50 (15 min) in rats: 3400000 mg/m3 (>800000 ppm); LC50 (4 hr) in rats: 2215000 mg/m3 (>500000 ppm) (Mayer)
化審法 (2)-3585
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H280 加圧ガス;熱すると爆発のおそれ 高圧ガス 高圧ガス
液化ガス
溶解ガス
警告 P410+P403
注意書き
P410+P403 日光から遮断し、換気の良い場所で保管するこ と。

1,1,1,2-テトラフルオロエタン 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-CFC-012S-2X Freon #134a (200 μg/mL in MeOH)
Freon #134a, 0.2 mg/mL in MeOH
811-97-2 1mL ¥7400 2018-12-26 購入
東京化成工業 T1476 1,1,1,2-テトラフルオロエタン >99.0%(GC)
1,1,1,2-Tetrafluoroethane (in cylinder without valve) [To use this product charged in cylinder, a valve is required which is sold separately (Product Code:V0030)] >99.0%(GC)
811-97-2 100g ¥11800 2018-12-04 購入

1,1,1,2-テトラフルオロエタン MSDS


1,1,1,2-Tetrafluoroethane

1,1,1,2-テトラフルオロエタン 化学特性,用途語,生産方法

用途

冷媒、溶媒、医薬品の噴射剤、発泡剤。

化学的特性

colourless gas or cryogenic liquid with an ether-like odour

化学的特性

Tetrafluoroethane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. The gas in high concentrations has a slight etherlike odor. Tetrafluoroethane is noncorrosive, nonirritating, and nonflammable.

使用

Refrigerant, propellant for pharmaceuticals; blowing agent for foams.

調製方法

Tetrafluoroethane can be prepared by several different routes; however, the following routes of preparation illustrate the methods used:
Isomerization/hydrofluorination of 1,1,2-trichloro-1,2,2-trifluoroethane (CFC-113) to 1,1-dichloro-1,2,2,2-tetrafluoroethane (CFC-114a), followed by hydrodechlorination of the latter. Hydrofluorination of trichloroethylene, via 1-chloro-1,1,1- trifluoroethane (HCFC-133a).

一般的な説明

A colorless gas with a slight ethereal odor. Vapors are heavier than air. Shipped liquefied under own vapor pressure. Flash point 351°F. Inhalation at high concentrations is harmful and may cause heart irregularities, unconsciousness or death without warning. Liquid contact may cause frostbite. Vapors can replace the available oxygen.

空気と水の反応

Insoluble in water.

反応プロフィール

1,1,1,2-Tetrafluoroethane is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. Can react with strong oxidizing agents or weaker oxidizing agents under extremes of temperature.

健康ハザード

Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.

火災危険

Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.

応用例(製薬)

Tetrafluoroethane is a hydrofluorocarbon (HFC) or hydrofluoroalkane (HFA) aerosol propellant (contains hydrogen, fluorine, and carbon) as contrasted to a CFC (chlorine, fluorine, and carbon). The lack of chlorine in the molecule and the presence of hydrogen reduce the ozone depletion activity to practically zero. Hence tetrafluoroethane is an alternative to CFCs in the formulation of metereddose inhalers (MDIs). It has replaced CFC-12 as a refrigerant and propellant since it has essentially the same vapor pressure. Its very low Kauri-butanol value and solubility parameter indicate that it is not a good solvent for the commonly used surfactants for MDIs. Sorbitan trioleate, sorbitan sesquioleate, oleic acid, and soya lecithin show limited solubility in tetrafluoroethane and the amount of surfactant that actually dissolves may not be sufficient to keep a drug readily dispersed. Up to 10% ethanol may be used to increase its solubility.
When tetrafluoroethane (P-134a) is used for pharmaceutical aerosols and MDIs, the pharmaceutical grade must be specified. Industrial grades may not be satisfactory due to their impurity profiles.

安全性

Tetrafluoroethane is used as a refrigerant and as a non-CFC propellant in various aerosols including topical pharmaceuticals and MDIs. Tetrafluoroethane is regarded as nontoxic and nonirritating when used as directed. No acute or chronic hazard is present when exposures to the vapor are below the acceptable exposure limit (AEL) of 1000 ppm, 8-hour and 12-hour time weighed average (TWA). In this regard it has the same value as the threshold limit value (TLV) for CFC-12. Inhaling a high concentration of tetrafluoroethane vapors can be harmful and is similar to inhaling vapors of CFC-12. Intentional inhalation of vapors of tetrafluoroethane can be dangerous and may cause death. The same labeling required on CFC aerosols would be required for those containing tetrafluoroethane as a propellant (except for the EPA requirement).

貯蔵

Tetrafluoroethane is a nonreactive and stable material. The liquified gas is stable when used as a propellant and should be stored in a metal cylinder in a cool dry place.

不和合性

The major incompatibility of tetrafluoroethane is its lack of miscibility with water. Since it has a very low Kauri-butanol value, tetrafluoroethane is considered to be a very poor solvent for most drugs used in MDI formulations. It also shows a low solubility for some of the commonly used MDI surfactants.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (aerosol formulations for inhalation and nasal applications). Included in nonparenteral medicines licensed in the UK.

1,1,1,2-テトラフルオロエタン 上流と下流の製品情報

原材料

準備製品


1,1,1,2-テトラフルオロエタン 生産企業

Global( 153)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hangzhou FandaChem Co.,Ltd.
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Zjartschem
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+86-571-87063838 jocelynpan@zjarts.com CHINA 670 58
Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Fluoropharm Co., Ltd.
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Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

811-97-2(1,1,1,2-テトラフルオロエタン)キーワード:


  • 811-97-2
  • AK134a
  • CF3CH2F
  • EcoloAce134a
  • ethane,1,1,1,2-tetrafluoro-
  • Forane134a
  • Freon134a
  • HC134a
  • HCFC-134a
  • HFA-134a
  • Norfluran
  • norflurane(INN)
  • RefrigerantR134a
  • SUVA134a
  • 1,1,1,2-TETRAFLUOROETHANE
  • HFC-134A
  • HALOCARBON 134A
  • FC-134A
  • TETRAFLUOROETHANE
  • QUICK FREEZE
  • R134A
  • norflurane
  • Tetrafluoroethane HFC-134a
  • HYDROFLUOROCARBON 134a
  • 1,1,1,2-TETRAFLUOROETHANE, 99+%
  • 1,1,1,2-Tetrafluoroethane(HFC-134a)99%
  • CFC134A
  • FLUOROCARBON134A
  • 1,1,1,2-Tetrafluoroethane (in cylinder without valve)
  • 1,1,2,2 Tetrafluorethane
  • Chemtronics Freez-It 2000
  • 1,1,1,2-テトラフルオロエタン
  • ノルフルラン
  • 1,2,2,2-テトラフルオロエタン
  • フレオン134a
  • フロン134a
  • 1,1,1,2テトラフルオロエタン
  • 1,1,1,2- テトラフルオロエタン (HFC-134a) 
  • 1,1,1,2-テトラフルオロエタン、
  • 1,1,1,2‐テトラフルオロエタン
  • FREON #134A (200 ΜG/ML IN MEOH)
  • ハライド(低沸点)
  • 研究用小型ガスボンベ
  • 有機合成化学
  • 冷媒
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