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カプレオマイシン

カプレオマイシン 化学構造式
11003-38-6
CAS番号.
11003-38-6
化学名:
カプレオマイシン
别名:
カプレオマイシン
英語化学名:
CAPREOMYCIN
英語别名:
capastat;capromycin;capostatin;kapreomycin;CAPREOMYCIN;CAPREOMYCINE;CaproMycin, Caprolin, Capastat, Capostatin, L 29275
CBNumber:
CB8471646
化学式:
C50H88N28O15
分子量:
1321.41232
MOL File:
11003-38-6.mol

カプレオマイシン 物理性質

酸解離定数(Pka):
pKa in 66% aq DMF: 6.2, 8.2, 10.1, 13.3(at 25℃)

安全性情報

カプレオマイシン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

カプレオマイシン 化学特性,用途語,生産方法

効能

抗結核薬, タンパク質合成阻害薬

使用

Capreomycin is a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin is a potent antibiotic with activity against mycobateria, Gram positive and Gram negative organisms. Capreomycin acts by binding to the 23S ribosomal subunit, disrupting protein synthesis.

適応症

Capreomycin (Capastat) is a polypeptide antibiotic derived from Streptomyces capreolus. It is bacteriostatic against most strains of M. tuberculosis, including the MDR strain. In addition, it is active against M. kansasii, M. avium, and in high concentrations, some grampositive and gram-negative bacteria. Like other antitubercular drugs, resistance to capreomycin occurs rapidly if the drug is used alone.There is no cross-resistance between streptomycin and capreomycin, but some isolates resistant to capreomycin are resistant to viomycin.

brand name

Capastat Sulfate (Lilly).

薬理学

Capreomycin is poorly absorbed from GI tract and so must be given parenterally. It is excreted mainly unchanged in the urine following glomerular filtration. Capreomycin is a used as a second-line agent in combination with other drugs. It appears to be particularly useful in multidrug regimens for the treatment of drugresistant tuberculosis, especially with streptomycin resistance. Capreomycin is associated with ototoxicity and nephrotoxicity, and these adverse effects can be severe in patients with preexisting renal insufficiency.

カプレオマイシン 上流と下流の製品情報

原材料

準備製品


カプレオマイシン 生産企業

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