N-メチルアデノシン

N-メチルアデノシン 化学構造式
1867-73-8
CAS番号.
1867-73-8
化学名:
N-メチルアデノシン
别名:
6-メチルアミノプリンリボシド;N6-メチルアデノシン;N-メチルアデノシン;メチル-6-アデノシン;(2R,3S,4R,5R)-2-(ヒドロキシメチル)-5-[6-(メチルアミノ)-9H-プリン-9-イル]オキソラン-3,4-ジオール
英語名:
6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
英語别名:
N6-Me-A;CS-1297;N6-Me-rA;N6-Me-Ar;NSC-29409;N6-Me-Adenosine;N-Methyladenosine;Adenosine, N-methyl-;N6,N6-Methyladenosin;Adenosine Impurity 15
CBNumber:
CB9503892
化学式:
C11H15N5O4
分子量:
281.27
MOL File:
1867-73-8.mol

N-メチルアデノシン 物理性質

融点 :
172 °C
沸点 :
649.1±65.0 °C(Predicted)
比重(密度) :
1.85±0.1 g/cm3(Predicted)
貯蔵温度 :
Keep in dark place,Sealed in dry,2-8°C
溶解性:
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
外見 :
Powder
酸解離定数(Pka):
13.12±0.70(Predicted)
安定性::
Hygroscopic

安全性情報

N-メチルアデノシン 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQB-1055 N6-メチルアデノシン
N6-Methyladenosine
1867-73-8 1g ¥45000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01COBQB-1055 N6-メチルアデノシン
N6-Methyladenosine
1867-73-8 5g ¥135000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01COBQB-1055 N6-メチルアデノシン
N6-Methyladenosine
1867-73-8 10g ¥215000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01FLC384967
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
1867-73-8 1g ¥48800 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC384967
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
1867-73-8 5g ¥144400 2021-03-23 購入

N-メチルアデノシン 化学特性,用途語,生産方法

説明

N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.

使用

N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.

定義

ChEBI: A methyladenosine compound with one methyl group attached to N6 of the adenine nucleobase.

N-メチルアデノシン 上流と下流の製品情報

原材料

準備製品


N-メチルアデノシン 生産企業

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1867-73-8(N-メチルアデノシン)キーワード:


  • 1867-73-8
  • NSC-29409
  • 6-Methylaminopurine D-riboside
  • 6-Methylaminopurine ribonucleoside
  • 6-Methylaminopurinosine
  • Adenosine, N-methyl-
  • (2R,3S,4R,5R)-2-(HydroxyMethyl)-5-(6-(MethylaMino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
  • N6-methyladenosine (m6A)
  • N6-Me-rA
  • N6-Me-A
  • 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
  • (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-methylaminopurin-9-yl)oxolane-3,4-diol
  • N-Methyladenosine
  • CS-1297
  • Adenosine Impurity 15
  • 2-(hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
  • N6,N6-Methyladenosin
  • N6-Me-Adenosine
  • N6-Me-Ar
  • N6-Methyladenosine RNA-modified nucleoside m6A
  • N-6-methyladenosine,inhibit,N6-Methyladenosine,Inhibitor,Endogenous Metabolite,N6methyladenosine,N6 methyladenosine,Influenza Virus
  • RNA-modified nucleoside m6A
  • 6-メチルアミノプリンリボシド
  • N6-メチルアデノシン
  • N-メチルアデノシン
  • メチル-6-アデノシン
  • (2R,3S,4R,5R)-2-(ヒドロキシメチル)-5-[6-(メチルアミノ)-9H-プリン-9-イル]オキソラン-3,4-ジオール
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