LL-37
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LL-37 속성
- 용해도
- Water: 1 mg/ml
- 물리적 상태
- A lyophilized powder
- 색상
- White to off-white
- 수용성
- Soluble to 1 mg/ml in water
- InChIKey
- POIUWJQBRNEFGX-XAMSXPGMSA-N
안전
LL-37 C화학적 특성, 용도, 생산
개요
LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.용도
L 37 (human) is a 37 amino acid host defense peptide originating from the C-terminal of the human cathelicidin antimicrobial peptide (CAMP, hCAP18). This peptide possesses antimicrobial, antitumor, antiviral, and immunomodulatory properties, along with physiological functions in chemotaxis, wound healing, and angiogenesis. Beyond its antimicrobial capabilities, LL 37 (human) influences various pathways in autoimmune and inflammatory diseases, playing a role in the development of lupus, rheumatoid arthritis, and atherosclerosis. As a binding partner to Aβ42, the expression of LL 37 (human) affects the onset and progression of Alzheimer's disease. Additionally, LL 37 has a notable role in human cancer, promoting tumorigenic effects in ovarian, lung, breast, prostate, pancreatic cancers, and malignant melanoma.benefits
LL-37 is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Significantly boosts immune function; Fights inflammation; Prevents cancer progression; Accelerates wound healing; Lowers the risk of heart disease; Prevents lung injury; Promotes bone repair.생물학적 활성
LL 37 is an antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. LL 37 reduces SARS-CoV-2 infection by blocking the receptor binding domain of the S1 spike protein (Kd = 11.2 nM) and by binding to ACE2 (Kd = 25.5.nM). LL 37 inhibits SARS-CoV-2 pseudovirion infection (IC50 = 4.74 μg/mL) in vitro and in vivo. Also triggers apoptosis in colon cancer cells. Cell permeable.부작용
LL-37 side effects are very uncommon. LL-37 induced apparent rosacea symptoms, erythema, and telangiectasia on the skin. Side effects associated with LL-37 may include the following:Increased inflammation
Induction of autoimmune disease
Depression
Damage to sperm surface membranes
참고 문헌
[1]Kahlenberg and Kaplan (2013) Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J. Immunol. 191(10) 4895 PMID: 24185823[2]Bandurska et al (2015) Unique features of human cathelicidin LL‐37. BioFactors 41 289 PMID: 26434733
[3]Chen et al (2018) Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer. Cell Physiol.Biochem. 47 1060 PMID: 29843147
[4]Vierthaler et al (2020) Fluctuating role of antimicrobial peptide hCAP18/LL?37 in oral tongue dysplasia and carcinoma. Oncol. Rep. 44 325 PMID: 32627035
[5]Wang, Guangshun. “Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.” The Journal of Biological Chemistry 283 47 (2008): 32637–43.
LL-37 준비 용품 및 원자재
원자재
준비 용품
LL-37 공급 업체
글로벌( 112)공급 업체
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Shanghai Affida new material science and technology center | +undefined15081010295 |
admin@oudaxin.com | China | 114 | 58 |
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sales03@chemcn.cn | China | 973 | 58 |
CONTIDE BIOTECH CO.,LTD | +44-7438349267 +44-7438349267 |
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Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 |
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Ethan@dornechem.com | China | 3128 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 |
asdf@shanghaihg.cn | China | 265 | 58 |
LL-37 관련 검색:
1-[[(9H-플로렌-9-일메톡시)카보닐]옥시]-2,5-필롤리딘디온
AC-MURAMYL-ALA-GLU-NH2
Polybia-MP1 trifluoroacetate salt
andropin
GAP 26
Prezatide copper acetate
ADRENOMEDULLIN (16-31) (HUMAN, PIG)
Thymosin α1
Acetyl Octapeptide-3
N-BOC-L-leucylglycyl-arginine-p-nitroanilide hydrochloride
H-LEU-ARG-ALA-HIS-ALA-VAL-ASP-VAL-ASN-GLY-NH2
Degarelix
Palmitoyl Pentapeptide
ADRENOMEDULLIN (HUMAN)
Argireline
Plecanatide
Amyloid β-Peptide (1-42) (human)
Dulaglutide