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Phlorizin

Phlorizin 구조식 이미지
카스 번호:
60-81-1
상품명:
Phlorizin
동의어(영문):
Floridzin;PHLORIZIN;phlorhizin;phlorizine;PHLORIDZIN;phloridzine;phlorrhizin;Phlorrhizen;phlorizoside;phloridzosid
CBNumber:
CB0331801
분자식:
C21H24O10
포뮬러 무게:
436.41
MOL 파일:
60-81-1.mol

Phlorizin 속성

녹는점
113-114 °C(lit.)
끓는 점
468.89°C (rough estimate)
밀도
1.3178 (rough estimate)
굴절률
-54 ° (C=3.2, 95% EtOH)
저장 조건
2-8°C
Merck
14,7327
CAS 데이터베이스
60-81-1(CAS DataBase Reference)
EPA
1-Propanone, 1-[2-(.beta.-D-glucopyranosyloxy)- 4,6-dihydroxyphenyl]-3-(4- hydroxyphenyl)-(60-81-1)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 3
RTECS 번호 UC2080000
F 고인화성물질 3-10-23
HS 번호 29389090

Phlorizin C화학적 특성, 용도, 생산

화학적 성질

Light Yellow Powder

용도

It is a dihydrochalcone occurring in all parts of the apple tree except the mature fruit. Once thought to occur in pear, plum, cherry trees and other Rosaceae

용도

induces experimental glucosuria, antifeedant

용도

Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes. Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits the initial rate of a-methyl-D-glucopyranoside (a-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.

정의

ChEBI: An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage.

효소 저해제

This glucosuria-inducing agent (FW = 436.42 g/mol; CAS 60-81-1), also known as phlorhizin, phloridzin, phlorrhizin, and 4,4’,6’-trihydroxy-2’- glucosidodihydrochalcone, is found in all parts of the apple tree except for the mature fruit. Phlorizin blocks glucose reabsorption in the kidney andintestine by inhibiting glucose/Na+ cotransporters as well as glucose transport into red blood cells and hepatocytes. Commercial phlorizin, typically supplied as the dihydrate, should be treated with activated charcoal before use and recrystallized from hot water. Note that muscle phosphorylase is much more inhibited than potato phosphorylase. Target(s): aldose 1-epimerase, or mutarotase; ATPase, chloroplast, and photophosphorylation; ATPase, mitochondrial; bicarbonate-chloride exchange; complement component C’3, guinea pig; galactosyltramsferase; glucose-6-phosphatase; glucose transport; glucoside 3-dehydrogenase; glycogen phosphorylase; glycogen synthase; lactase, or lactase/phlorizin hydrolase, or glycosylceramidase; laminaribiose phosphorylase; Na+ /myo-inositol cotransporter; Na+ /K+ -exchanging ATPase; phloretin hydrolase; 3-phytase; starch phosphorylase, weakly inhibited; sucrose phosphorylase; a,a-trehalase; tyrosinase, monophenol monooxygenase, weakly inhibited.

Purification Methods

-D-glucoside] [60-81-1] M 472.5, m 110o, [] 20 -62o (c 3.2, EtOH). Phlorizin crystallises as the dihydrate from water and causes glycosuria. [Brazy & Dennis Am J Physiol 234 1279 1978, Zemplen & Bognár Chem Ber 17B 1040 1943, Beilstein 17/7 V 177.]

Phlorizin 준비 용품 및 원자재

원자재

준비 용품


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