Chinese English Japanese Germany Korea


Phlorizin 구조식 이미지
카스 번호:
포뮬러 무게:
MOL 파일:

Phlorizin 속성

113-114 °C(lit.)
끓는 점
468.89°C (rough estimate)
1.3178 (rough estimate)
-54 ° (C=3.2, 95% EtOH)
저장 조건
CAS 데이터베이스
60-81-1(CAS DataBase Reference)
1-Propanone, 1-[2-(.beta.-D-glucopyranosyloxy)- 4,6-dihydroxyphenyl]-3-(4- hydroxyphenyl)-(60-81-1)


위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 3
RTECS 번호 UC2080000
F 고인화성물질 3-10-23
HS 번호 29389090

Phlorizin C화학적 특성, 용도, 생산

화학적 성질

Light Yellow Powder


It is a dihydrochalcone occurring in all parts of the apple tree except the mature fruit. Once thought to occur in pear, plum, cherry trees and other Rosaceae


induces experimental glucosuria, antifeedant


Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes. Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits the initial rate of a-methyl-D-glucopyranoside (a-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.


ChEBI: An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage.

효소 저해제

This glucosuria-inducing agent (FW = 436.42 g/mol; CAS 60-81-1), also known as phlorhizin, phloridzin, phlorrhizin, and 4,4’,6’-trihydroxy-2’- glucosidodihydrochalcone, is found in all parts of the apple tree except for the mature fruit. Phlorizin blocks glucose reabsorption in the kidney andintestine by inhibiting glucose/Na+ cotransporters as well as glucose transport into red blood cells and hepatocytes. Commercial phlorizin, typically supplied as the dihydrate, should be treated with activated charcoal before use and recrystallized from hot water. Note that muscle phosphorylase is much more inhibited than potato phosphorylase. Target(s): aldose 1-epimerase, or mutarotase; ATPase, chloroplast, and photophosphorylation; ATPase, mitochondrial; bicarbonate-chloride exchange; complement component C’3, guinea pig; galactosyltramsferase; glucose-6-phosphatase; glucose transport; glucoside 3-dehydrogenase; glycogen phosphorylase; glycogen synthase; lactase, or lactase/phlorizin hydrolase, or glycosylceramidase; laminaribiose phosphorylase; Na+ /myo-inositol cotransporter; Na+ /K+ -exchanging ATPase; phloretin hydrolase; 3-phytase; starch phosphorylase, weakly inhibited; sucrose phosphorylase; a,a-trehalase; tyrosinase, monophenol monooxygenase, weakly inhibited.

Purification Methods

-D-glucoside] [60-81-1] M 472.5, m 110o, [] 20 -62o (c 3.2, EtOH). Phlorizin crystallises as the dihydrate from water and causes glycosuria. [Brazy & Dennis Am J Physiol 234 1279 1978, Zemplen & Bognár Chem Ber 17B 1040 1943, Beilstein 17/7 V 177.]

Phlorizin 준비 용품 및 원자재


준비 용품

Phlorizin 공급 업체

글로벌( 163)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3203 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32452 55
Hebei Chisure Biotechnology Co., Ltd.
0311 66567340 CHINA 1019 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 25796 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2236 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 CHINA 2972 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23958 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20084 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 8266 58

Copyright 2019 © ChemicalBook. All rights reserved