그란자임B
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그란자임B 속성
- 저장 조건
- -70°C
- 물리적 상태
- 완충 수용액
안전
위험 카페고리 넘버 | 42/43 | ||
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안전지침서 | 26-36 | ||
WGK 독일 | - |
그란자임B C화학적 특성, 용도, 생산
일반 설명
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.Biochem/physiol Actions
Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.그란자임B 준비 용품 및 원자재
원자재
준비 용품
그란자임B 공급 업체
글로벌( 29)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Creative Enzymes | 1-516-855-7709 |
info@creative-enzymes.com | United States | 8748 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 |
422450190@qq.com | China | 10351 | 58 |
Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 |
sales@shzbio.com | China | 9966 | 58 |
Biolab Reagents | 027-65279366 18162686757 |
products@biolabreagent.com | China | 9818 | 58 |
그란자임B 관련 검색:
실버 아세틸아세토네이트 아세틸아세톤산 구리 아세틸아세토산 제2철 코발트(II) 아세틸아세토네이트 하이드레이트 알루미늄 아세틸아세토네이트 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트)
METHYL ISOCYANOACETATE
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
Tosylmethyl isocyanide
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
TERT-BUTYL ISOCYANIDE
SALCOMINE
N-BUTYLISOCYANIDE
Ethyl isocyanoacetate
Tris(2,4-pentanedionato)chroMiuM(III)
PHENYLSELENOL
Benzyl isocyanide