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GRANZYME B

GRANZYME B 구조식 이미지
카스 번호:
143180-74-9
상품명:
GRANZYME B
동의어(영문):
GZMB;GRANZYME B;EC 3.4.21.79;GRANZYME B ENZYME;GRANZYME B (HUMAN);Granzyme B from mouse;Granzyme B from Mouse, Recombinant;Granzyme B from Human, Recombinant;Recombinant Mouse Gzmb Protein, His Tag;SensiZyme Granzyme B Activity Assay Kit
CBNumber:
CB1120279
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

GRANZYME B 속성

저장 조건
-70°C
물리적 상태
buffered aqueous solution

안전

위험 카페고리 넘버 42/43
안전지침서 26-36
WGK 독일 -

GRANZYME B C화학적 특성, 용도, 생산

일반 설명

Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.

Biochem/physiol Actions

Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.

GRANZYME B 준비 용품 및 원자재

원자재

준비 용품


GRANZYME B 공급 업체

글로벌( 28)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Creative Enzymes
1-631-619-7922
1-631-938-8127 info@creative-enzymes.com United States 8748 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15877 69
Wuhan Chemstan Biotechnology Co., Ltd. 15926423062
QQ:422450190 422450190@qq.com China 10081 58

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