HOE 140

HOE 140 구조식 이미지
카스 번호:
130308-48-4
상품명:
HOE 140
동의어(영문):
S-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP
CBNumber:
CB1318492
분자식:
C59H89N19O13S
포뮬러 무게:
1304.52
MOL 파일:
130308-48-4.mol

HOE 140 속성

밀도
1.60±0.1 g/cm3(Predicted)
저장 조건
Sealed in dry,2-8°C
용해도
Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
물리적 상태
가루
산도 계수 (pKa)
3.60±0.21(Predicted)
색상
하얀색
수용성
Soluble to 1 mg/ml in water
시퀀스
H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
InChIKey
QASONHYHOCRAHL-DOMVFXHKSA-N
CAS 데이터베이스
130308-48-4

안전

WGK 독일 3

HOE 140 C화학적 특성, 용도, 생산

개요

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

용도

Antagonist (bradykinin).

정의

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.

상표명

Metastat (CollaGenex).

HOE 140 준비 용품 및 원자재

원자재

준비 용품


HOE 140 공급 업체

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