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노르메타돈

노르메타돈
노르메타돈 구조식 이미지
카스 번호:
467-85-6
한글명:
노르메타돈
동의어(한글):
노르메타돈
상품명:
normethadone
동의어(영문):
normethadone;Hoechst 10,582;WCJFBSYALHQBSK-UHFFFAOYSA-N;6-Dimethylamino-4,4-diphenyl-3-hexanone;6-(Dimethylamino)-4,4-diphenyl-3-hexanone;6-(dimethylamino)-4,4-diphenylhexan-3-one;3-Hexanone, 6-(dimethylamino)-4,4-diphenyl-
CBNumber:
CB1901939
분자식:
C20H25NO
포뮬러 무게:
295.42
MOL 파일:
467-85-6.mol

노르메타돈 속성

녹는점
<25 °C
끓는 점
bp3 164-167°
밀도
1.0389 (rough estimate)
굴절률
1.5614 (estimate)
산도 계수 (pKa)
pKa 6.00(50% aq EtOH) (Uncertain)

안전

노르메타돈 C화학적 특성, 용도, 생산

Originator

Normethadone, Isotec, Inc.

Manufacturing Process

65 g of thin powder sodium amide was added to a solution of 289 g diphenylacetonitrile in 300 ml benzene for 15-20 minutes at temperature 45°50°C. Then the mixture was cooled to about 25°C, 182 g 2dimethyaminoethylchloride was added dropwise. On ending the reaction it was heated to reflux for 15 minutes, diluted with water, the benzene layer separated and washed with diluted hydrochloric acid. The acid layer was alkalified with sodium hydroxide, extracted with ether and dried over potash. The ether was distilled off to dryness and the residue solidified to give colorless crystals of 4-dimethylamino-2,2-diphenylbutyronitrile. The C2H5MgBr was made from 66.5 g of magnesium, 300 ml dry ether and 33 g ethyl bromide and mixed with above prepared nitrile in 150 ml toluene. After the ending of reaction, the mixture was heated for 1.5 hour on the steam bath to give hard-grained bulk. It was mixed with 600 ml concentrate hydrochloric acid in 1500 ml water. On cooling 500 ml benzene was added and three layers arose. The middle layer crystallized shortly. The crystals were filtered off, washed with 100 ml 2 N hydrochloric acid and 3 x 100 ml acetone. 6Dimethylamino-4,4-diphenyl-3-hexanone was prepared as a hydrochloride. MP: 231°C. The salt may be transformed into the base by adding of an equivalent of any basic compound (triethyl amine, soda and so on).

Therapeutic Function

Narcotic analgesic, Antitussive

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