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트리아졸람

트리아졸람
트리아졸람 구조식 이미지
카스 번호:
28911-01-5
한글명:
트리아졸람
동의어(한글):
트리아졸람
상품명:
Triazolam
동의어(영문):
Songar;Halcyon;Asasion;Halcion;U-33,030;novidorm;Novodorm;D II-18-2;TRIAZOLAM;clorazolam
CBNumber:
CB2218405
분자식:
C17H12Cl2N4
포뮬러 무게:
343.21
MOL 파일:
28911-01-5.mol

트리아졸람 속성

녹는점
209-212°C
끓는 점
499.51°C (rough estimate)
밀도
1.2835 (rough estimate)
굴절률
1.6300 (estimate)
인화점
11 °C
저장 조건
2-8°C
산도 계수 (pKa)
pKa 1.52(H2O) (Uncertain);6.5(H2O) (Uncertain)
수용성
30mg/L(ambient temperature)
CAS 데이터베이스
28911-01-5(CAS DataBase Reference)
NIST
Triazolam(28911-01-5)
EPA
Triazolam (28911-01-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,T
위험 카페고리 넘버 11-23/24/25-36/38-39/23/24/25
안전지침서 22-24/25-26-36-45-36/37-16-7
유엔번호(UN No.) 3249
WGK 독일 2
RTECS 번호 XZ5472500
위험 등급 6.1(b)
포장분류 III
HS 번호 2933910000
유해 물질 데이터 28911-01-5(Hazardous Substances Data)
독성 LD50 in mice, rats (mg/kg): >100, >5000 orally (Pharm. Weekblad.)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

트리아졸람 C화학적 특성, 용도, 생산

화학적 성질

Yellow Solid

Originator

Halcion,Upjohn,Switz.,1978

용도

Sedative, hypnotic. Controlled substance (depressant).

용도

Triazolam

Manufacturing Process

A mixture of 1.0g (0.0031 mol) of 7-chloro-1,3-dihydro-5-(o-chlorophenyl)- 2H-1,4-benzodiazepine-2-thione, 0.8 g (0.0108 mol) of acetic acid hydrazide and 40 ml of 1-butanol was heated at reflux temperature under nitrogen for 24 hours. During the first 5 hours the nitrogen was slowly bubbled through the solution. After cooling and removing the solvent in vacuo, the product was well mixed with water and collected on a filter, giving 0.9 g of orange solid, melting point 210°C to 212°C. This was heated under nitrogen in an oil bath at 250°C and then cooled, The solid was crystallized from ethyl acetate, giving 0.5 g of tan solid of melting point 215°C to 216°C (decomposition). This was dissolved in 25 ml of 2-propanol, filtered, concentrated to10 ml and cooled, yielding 0.46 g (43%) of tan, crystalline 8-chloro-1-methyl-6-(o_x0002_chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine of melting point 223°C to 225°C.

상표명

Novoderm;Nuctane;Songarn.

Therapeutic Function

Hypnotic

World Health Organization (WHO)

Triazolam, a benzodiazepine derivative with sedative and hypnotic activity, was introduced in 1978 for themanagement of insomnia. It is controlled under Schedule IV of the 1971 Convention of Psychotropic Substances. Concern regarding the psychotropic effects of triazolam was first raised in the Netherlands in 1979 when this compound was suspended for sale and subsequently withdrawn by the Committee for the Evaluation of Medicines on the basis of reports of a reversible complex of symptoms including paranoia, depersonalization, nightmares, suicidal tendency and hyperaesthesia in patients receiving the drug. The basis for this decision was later successfully contested by the manufacturer and the drug was reregistered in early 1990 with a revised product information. However, concern was regenerated elsewhere that higher doses are associated with an unacceptable incidence of unwanted effects and the manufacturer has eventually withdrawn 0.5 mg tablets on a worldwide basis. In 1991 the issue of the safety of triazolam was again reopened by reports of retrograde amnesia and depression among patients taking the decreased recommended dosages. The product information has been revised by the United States FDA to include more rigorous cautions regarding dosage. In the Member States of the European Communities the products have been suspended pending further review by the EC Committee on Proprietary Medicinal Products.

일반 설명

Triazolam, 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4] benzodiazepine(Halcion), has all of the characteristic benzodiazepine pharmacologicalactions. It is an ultra–short-acting hypnoticbecause it is rapidly α-hydroxylated to the 1-methyl alcohol,which is then rapidly conjugated and excreted.Consequently, it has gained popularity as sleep inducers, especiallyin elderly patients, because it causes less daytimesedation. It is metabolically inactivated primarily by hepaticand intestinal CYP3A4; therefore, coadministration withgrapefruit juice increases its peak plasma concentration by30%, leading to increased drowsiness.

트리아졸람 준비 용품 및 원자재

원자재

준비 용품


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