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메틸파라벤

메틸파라벤
메틸파라벤 구조식 이미지
카스 번호:
99-76-3
한글명:
메틸파라벤
동의어(한글):
p-히드록시안식향산메틸;메틸파라벤;4-히드록시벤조산,메틸에스테르;4-히드록시벤조익액시드메틸에스테르;p-옥시안식향산메틸;P-히드록시벤조산,메틸에스테르;메틸P-옥시벤조에이트;메틸P-히드록시벤조에이트;메틸파라히드록시벤조에이트;메틸파라세프트;4-하이드록시안식향산메틸;메틸파라벤
상품명:
Methylparaben
동의어(영문):
Abiol;Moldex;Septos;metaben;NIPAGIN;Nigagin;Paraben;Paridol;Solbrol;methaben
CBNumber:
CB0184566
분자식:
C8H8O3
포뮬러 무게:
152.15
MOL 파일:
99-76-3.mol

메틸파라벤 속성

녹는점
125-128 °C(lit.)
끓는 점
298.6 °C
밀도
1,46g/cm
증기압
0.000005 hPa (20 °C)
굴절률
1.4447 (estimate)
FEMA
2710 | METHYL P-HYDROXYBENZOATE
인화점
280°C
저장 조건
0-6°C
용해도
ethanol: soluble0.1M, clear, colorless
물리적 상태
Crystalline Powder
산도 계수 (pKa)
pKa 8.15(H2O,t =20.0) (Uncertain)
색상
White to almost white
수소이온지수(pH)
5.8 (H2O, 20°C) (saturated solution)
수용성
Slightly soluble in water.
어는점
131℃
Merck
14,6107
BRN
509801
안정성
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
LXCFILQKKLGQFO-UHFFFAOYSA-N
CAS 데이터베이스
99-76-3(CAS DataBase Reference)
NIST
Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA
Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,Xn
위험 카페고리 넘버 36/37/38-20/21/22-36
안전지침서 26-36-24/25-39
유엔번호(UN No.) UN 2769
WGK 독일 1
RTECS 번호 DH2450000
자연 발화 온도 >600 °C
TSCA Yes
HS 번호 29182930
유해 물질 데이터 99-76-3(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 2100 mg/kg
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P273 환경으로 배출하지 마시오.

메틸파라벤 MSDS


4-Hydroxybenzoic acid methyl ester

메틸파라벤 C화학적 특성, 용도, 생산

화학적 성질

Colorless crystals or white, crystallinepowder; odorless or faint characteristic odor; slightburning taste. Soluble in alcohol,ether; slightly soluble in water, benzene, and carbontetrachloride.

화학적 성질

Methylparaben occurs as colorless crystals or a white crystalline powder. It is odorless or almost odorless and has a slight burning taste.

화학적 성질

Methyl p-hydroxybenzoate is odorless or has a faint characteristic odor and a slight burning taste. Methyl p-hydroxybenzoate is more commonly known as methyl paraben and is an ester of p-hydroxybenzoic acid.

출처

Reported present in cloudberry, yellow passion fruit juice, white wine, botrytised wine and Bourbon vanilla.

용도

It is used as preservative in foods, beverages and cosmetics.

용도

As preservative in foods, beverages and cosmetics.

용도

parabens is one of the most commonly used group of preservatives in the cosmetic, pharmaceutical, and food industries. Parabens provide bacteriostatic and fungistatic activity against a diverse number of organisms, and are considered safe for use in cosmetics, particularly in light of their low sensitizing potential. An evaluation of preservatives for use in leave-on cosmetic preparations lists parabens among the least sensitizing. The range of concentrations used in cosmetics varies between 0.03 and 0.30 percent, depending on the conditions for use and the product to which the paraben is added.

용도

Methylparaben is an antimicrobial agent which is a white free-flowing powder. it is active against yeast and molds over a wide ph range. see parabens.

정의

ChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.

제조 방법

Produced by the methanol esterification of p-hydroxybenzoic acid in the presence of sulfuric acid. The materials are heated for distillation in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

생산 방법

Methylparaben is prepared by the esterification of p-hydroxybenzoic acid with methanol.

Aroma threshold values

Detection: 2.6 ppm.

위험도

Toxic. Use in foods restricted to 0.1%.

Pharmaceutical Applications

Methylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations; see Table I. It may be used either alone or in combination with other methylparaben is the most frequently used antimicrobial preservative.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Antimicrobial activity increases as the chain length of the alkyl moiety is increased, but aqueous solubility decreases; therefore a mixture of parabens is frequently used to provide effective preservation. Preservative efficacy is also improved by the addition of propylene glycol (2–5%), or by using parabens in combination with other antimicrobial agents such as imidurea;
Owing to the poor solubility of the parabens, paraben salts (particularly the sodium salt) are more frequently used in formulations. However, this raises the pH of poorly buffered formulations.
Methylparaben (0.18%) together with propylparaben (0.02%) has been used for the preservation of various parenteral pharmaceutical formulations;

색상 색인 번호

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Methylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations. Although parabens have also been used as preservatives in injections and ophthalmic preparations, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. These experiences may depend on immune responses to enzymatically formed metabolites of the parabens in the skin.
Parabens are nonmutagenic, nonteratogenic, and noncarcinogenic. Sensitization to the parabens is rare, and these compounds do not exhibit significant levels of photocontact sensitization or phototoxicity.
Hypersensitivity reactions to parabens, generally of the delayed type and appearing as contact dermatitis, have been reported. However, given the widespread use of parabens as preservatives, such reactions are relatively uncommon; the classification of overstated. Immediate hypersensitivity reactions following injection of preparations containing parabens have also been reported.
Delayed-contact dermatitis occurs more frequently when parabens are used topically, but has also been reported to occur after oral administration.
Unexpectedly, preparations containing parabens may be used by patients who have reacted previously with contact dermatitis provided they are applied to another, unaffected, site. This has been termed the paraben paradox.
Concern has been expressed over the use of methylparaben in infant parenteral products because bilirubin binding may be affected, which is potentially hazardous in hyperbilirubinemic neonates.
The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg bodyweight.
LD50 (dog, oral): 3.0 g/kg
LD50 (mouse, IP): 0.96 g/kg
LD50 (mouse, SC): 1.20 g/kg

저장

Aqueous solutions of methylparaben at pH 3–6 may be sterilized by autoclaving at 120°C for 20 minutes, without decomposition. Aqueous solutions at pH 3–6 are stable (less than 10% decomposition) for up to about 4 years at room temperature, while aqueous solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days storage at room temperature);
Methylparaben should be stored in a well-closed container in a cool, dry place.

Purification Methods

Fractionally crystallise the ester from its melt, and recrystallise it from *benzene, then from *benzene/MeOH and dry it over CaCl2 in a vacuum desiccator. [Beilstein 10 IV 360.]

비 호환성

The antimicrobial activity of methylparaben and other parabens is considerably reduced in the presence of nonionic surfactants, such as polysorbate 80, as a result of micellization.However, propylene glycol (10%) has been shown to potentiate the antimicrobial activity of the parabens in the presence of nonionic surfactants and prevents the interaction between methylparaben and polysorbate 80.
Incompatibilities with other substances, such as bentonite, magnesium trisilicate,talc,tragacanth,sodium alginate, essential oils,sorbitol,and atropine,have been reported. It also reacts with various sugars and related sugar alcohols. Absorption of methylparaben by plastics has also been reported; the amount absorbed is dependent upon the type of plastic and the vehicle. It has been claimed that low-density and high-density polyethylene bottles do not absorb methylparaben.
Methylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Methylparaben and propylparaben are affirmed GRAS Direct Food Substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%.
Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalation preparations; ophthalmic preparations; oral capsules, tablets, solutions and suspensions; otic, rectal, topical, and vaginal preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

메틸파라벤 준비 용품 및 원자재

원자재

준비 용품


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