OREXIN B (HUMAN)

OREXIN B (HUMAN) 구조식 이미지
카스 번호:
205640-91-1
상품명:
OREXIN B (HUMAN)
동의어(영문):
HYPOCRETIN-2;Human orexin B;OREXIN B (HUMAN);HYPOCRETIN-2, HUMAN;OREXIN B HUMAN ≥98%;PubChem ID: 90479794;OREXINS OREXIN B HUMAN;OREXIN B (HUMAN) USP/EP/BP;Orexin B (human), ≥98% (HPLC);RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
CBNumber:
CB2384164
분자식:
C123H212N44O35S
포뮬러 무게:
2899.34
MOL 파일:
205640-91-1.mol

OREXIN B (HUMAN) 속성

밀도
1.49±0.1 g/cm3(Predicted)
저장 조건
-20°C
수용성
Soluble to 1 mg/ml in Water
시퀀스
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

안전

WGK 독일 3
HS 번호 2937190000

OREXIN B (HUMAN) C화학적 특성, 용도, 생산

개요

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance. It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells. It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons. Orexin B stimulates arachidonic acid release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM). It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.

Biochem/physiol Actions

Orexins/Hypocretins, Orexin A/ hypocretin-1 and Orexin B/ hypocretin-2, are excitatory neuropeptides that mediate there effects via two receptors, OX-1 and OX-2. Orexins are involved in food intake, obesity regulation, energy homeostasis and differentiation.

OREXIN B (HUMAN) 준비 용품 및 원자재

원자재

준비 용품


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