장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재)
특정 표적장기 독성 - 1회 노출
구분 1
위험
P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210
열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P311
의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
4
0
Remifentanil Hydrochloride C화학적 특성, 용도, 생산
개요
Ultiva was launched in Germany and the US for use in general anesthesia
and immediate post-operative pain management. This compound can be prepared
via the Michael addition of a 4,4-disubstituted piperidine to methyl acrylate. It
behaves as a specific μ-opiod agonist that is about 30 times more potent than its
chemical relative alfentanil. While its pharmacodynamic properties are similar to
other μ agonists, remifentanil has unique pharmacokinetic properties. It has a rapid
onset (1.6 min) and a rapid offset (5.4 min) independent of duration of administration.
This has been attributed to its rapid catabolism by general esterases to the
corresponding acrylic acid derivative. The metabolite has 0.01 to 0.0005 times the
activity of remifentanil and is excreted via the kidneys (80% recovery).
화학적 성질
White Solid
용도
Labelled synthetic mu-opioid agonist. This is a controlled substance (opiate)
Pharmacokinetics
Remifentanil is much like alfentanil in its pharmacodynamic effects. It is a selective μ opioid agonist
with 15 to 20 times greater potency than alfentanil. Remifentanil has an onset of
action of 1 to 3 minutes when given intravenously. Its unique property is its rapid
offset of action, which is independent of the duration of administration of the compound. Thus, it is
very useful for titration of antinociceptive effect, followed by a rapid and predictable recovery time
of 3 to 5 minutes. The short duration of action is a result of the ester group, which has been
rationally designed into the substituent on the piperidine nitrogen. This ester group is rapidly
hydrolyzed to the inactive carboxylic acid by serum and tissue esterases, making the drug's
duration of action essentially independent of the liver or renal function of the patient. Remifentanil
is used extensively for analgesia associated with general anesthesia procedures. It often is used in
combination with injectable general anesthetic agents, such as midazolam or propofol.
