trans/cis Resveratrol-D4

trans/cis Resveratrol-D4 속성

trans/cis Resveratrol-D4 C화학적 특성, 용도, 생산

개요

trans-Resveratrol-d₄ is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC₅₀s = 15 and 3.7 μM, respectively), but not COX-2 (EC₅₀s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; ; EC₅₀ = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC₅₀s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.

용도

Resveratrol-d4 is labelled Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.

trans/cis Resveratrol-D4 준비 용품 및 원자재

원자재

준비 용품

trans/cis Resveratrol-D4 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9685	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
Guangzhou Dreampharm Biotechnology Co., Ltd.	17825480238	3008233717@qq.com	China	9844	12
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Hubei Xinyang Medical Technology Co., Ltd	15347293736 15347293736	2853117764@qq.com	China	8842	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Nanjing Shizhou Biology Technology Co.,Ltd	17301488900	judy.xia@synzest.com	China	13698	58

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