1,8-디히드록시안트라퀴논
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1,8-디히드록시안트라퀴논 속성
- 녹는점
- 191-193 °C (lit.)
- 끓는 점
- 342.92°C (rough estimate)
- 밀도
- 1.3032 (rough estimate)
- 굴절률
- 1.5430 (estimate)
- 인화점
- >200°C
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- very faint turbidity in hot Acetic acid
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 6.27±0.20(Predicted)
- 색상
- 주황색 갈색 또는 갈색
- 수용성
- 불용성
- Merck
- 14,2815
- BRN
- 2054727
- LogP
- 4.570 (est)
- CAS 데이터베이스
- 117-10-2(CAS DataBase Reference)
- IARC
- 2B (Vol. 50) 1990
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 40 | ||
안전지침서 | 36/37-36-22 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 1 | ||
RTECS 번호 | CB6650000 | ||
TSCA | Yes | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29146990 | ||
유해 물질 데이터 | 117-10-2(Hazardous Substances Data) | ||
독성 | LD50 orally in mice: <7 g/kg (Case) | ||
기존화학 물질 | 2014-2-98 |
1,8-디히드록시안트라퀴논 C화학적 특성, 용도, 생산
개요
Danthron, a natural product, was originally extracted from the roots and rhizome of Polygonaceae plant, also called Da Huang in traditional Chinese herbal medicine. Now it is synthesized in many countries, such as Germany, India, Japan, Poland, the United Kingdom, and the United States. Danthron is reasonably anticipated to be a human carcinogen.Danthron is an anthraquinone that exists at room temperature as a red or orange crystalline powder.It is practically insoluble in water, but soluble in a variety of solvents (acetone, chloroform, diethyl ether, ethanol) and alkaline hydroxide solutions. The stability of danthron is generally good. It is stable under room temperatures and normal pressures.
화학적 성질
orange-brown or brown powder용도
1,8-Dihydroxyanthraquinone can be used:- To prepare an inclusion complex with β-cyclodextrin, applicable as a sensor in the estimation of Cu2+?ions in an aqueous solution.
- As a starting material in the synthesis of 1,4,5,8-tetramethoxyanthracene.
- As an aromatic scavenger in the modification of lignin, which acts as a corrosion inhibitor for steel.
정의
ChEBI: 1,8-Dihydroxyanthraquinone is a dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 8. It has a role as an apoptosis inducer and a plant metabolite.World Health Organization (WHO)
Dantron, an anthroquinone derivative, has been available for over twenty years and is widely used as a laxative. The results of two chronic toxicity studies in rodents, published in 1985 and 1986, have shown that administration of high doses is associated with the development of intestinal and liver tumours.일반 설명
Orange crystalline powder. Almost odorless and tasteless.공기와 물의 반응
Insoluble in water.반응 프로필
1,8-Dihydroxyanthraquinone is incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides.화재위험
Flash point data for 1,8-Dihydroxyanthraquinone are not available; however, 1,8-Dihydroxyanthraquinone is probably combustible.부작용
Liver injury may occur with 1,8-Dihydroxyanthraquinone when used as a laxative for one year. Symptoms disappeared after discontinuation of the drug, but recurred after resumption of the drug; none of the drugs administered alone had any effect on liver function test results. In addition, deep skin discolouration may occur with heavy use, mainly in elderly subjects, and is limited to the buttocks and thighs, with mild signs of inflammation. Skin contact with faeces or urine containing the drug appears to be a prerequisite for discolouration. Inflammation, if present, may be due to reduction of the parent compound in the colon to diol derivatives, which can irritate the intestine and skin in a way that the parent compound does not. There is also the possibility of colorectal melanosis.Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by intraperitoneal route. An eye irritant. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A laxative. When heated to decomposition it emits acrid smoke and irritating fumes.잠재적 노출
A potential liver carcinogen and possible narcotic, this compound is no longer sold or marketed in the United States Nervous system toxin-acute effects; Respiratory toxin-acute effects other than severe or moderate irritation; Liver-acute effects; Eye irritant-mild.Carcinogenicity
Danthron is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.환경귀착
Danthron can cause DNA damage particularly at guanines in the 5'-GG-3', 5'-GGGG-3', 5'-GGGGG-3' sequences in the presence of Cu(II), cytochrome P450 reductase and the nicotinamide adenine dinucleotide phosphate (NADPH)-generating system. H2O2 and Cu(I) may also be involved because this DNA damage can be inhibited by catalase and bathocuproine. The further mechanism is danthron is reduced by P450 reductase and generate reactive oxygen species through the redox cycle, leading to extensive Cu(II)-mediated DNA damage. The DNA damage also comes from similar topoisomerase II inhibitor behavior of danthron.운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Purification Methods
Crystallise Danthrone from EtOH and sublime it in a vacuum. [Beilstein 8 IV 3217.]비 호환성
Keep away from strong reducing agents, such as hydrides, nitrides, alkali metals, and sulfides.폐기물 처리
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double- bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to prop- erly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.1,8-디히드록시안트라퀴논 준비 용품 및 원자재
원자재
9,10-Anthracenedione, 1,8-bis(2-propyn-1-yloxy)-
1,8-DIACETOXYANTHRAQUINONE
3-Nitrophthalic anhydride
준비 용품
1,8-디히드록시안트라퀴논 공급 업체
글로벌( 431)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 811 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
1,8-디히드록시안트라퀴논 관련 검색:
안트라플라빈 알로에 에모딘 4,5-다이나이트로크리사진 1,8-디히드록시안트라퀴논 도옥소루비신 알리자린 1,2,3,4-사염화-5,8-디하이드록시 안트라퀴논 1,4-다이하이드록시안트라퀴논 C.I. 디스퍼스 블루 056 알리자린 플루오린 블루 1,5-디아미노클로로-4,8-디하이록시안트라퀴논 안트라퀴논 알리자린 레드 S 1,5-디아미노-2-브로모-4,8-디하이록시-9,10-안트라센디온
Emodin
2-Methyl-4,5-dihydroxyanthraquinon
4,5-diamino-1,8-dihydroxyanthraquinon
Emodin-3-methyl ether