피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P363
다시 사용전 오염된 의류는 세척하시오.
P405
밀봉하여 저장하시오.
NFPA 704
1
3
1
TRIISOPROPYLSILYL TRIFLUOROMETHANESULFONATE C화학적 특성, 용도, 생산
화학적 성질
clear light brown to orange-brown liquid
물리적 성질
Colorless oil; bp 83–87 °C/1.7 mmHg; d 1.173
g cm?3.
용도
Triisopropylsilyl Trifluoromethanesulfonate is a highly reactive silylating agent and Lewis acid capable of converting
primary and secondary alcohols to the corresponding triisopropylsilyl
ethers and converting ketones and lactones into
their enol silyl ethers; protection of terminal alkynes; promoting
conjugate addition of alkynylzinc compounds to α,β-enones;
preparation of (triisopropylsilyl)diazomethane, participating in the following (but not limited to) reactions: Silylation of Alcohols, Formations of Enol Silyl Ethers, Alkynyltriisopropylsilanes, Conjugate Addition of Alkynylzinc Bromides, (Triisopropylsilyl)diazomethane, Triisopropylsiloxycarbonyl (Tsoc) and BIPSOP Protecting Groups for Amines, TIPS Protection for Oxazoles/Regioselective Trapping of C-2 Oxazole Anions, Benzannulation Using Triisopropylsilyl Vinyl Ketenes, Cyclization of 1-Silyloxy-1,5-diynes, Desymmetrization of Tartaric Acid Esters etc.
제조 방법
To 38.2 g (0.242 mol) of triisopropylsilane
at 0°C under argon is added 23.8 mL (0.266 mol) of trifluoromethanesulfonic
acid dropwise. The solution is stirred at
22°C for 16 h, at which time no further hydrogen gas evolves
(removed through a bubbler). The resulting product is distilled
through a 30-cm vacuum jacketed Vigreux column under
reduced pressure: 71.7 g (97% yield) of TIPS triflate;
bp 83–87°C/1.7 mmHg.
TRIISOPROPYLSILYL TRIFLUOROMETHANESULFONATE 준비 용품 및 원자재
