Alpelisib (BYL719)
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Alpelisib (BYL719) 속성
- 밀도
- 1.391
- 저장 조건
- Store at -20°C
- 용해도
- ≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- 물리적 상태
- 백색 고체.
- 산도 계수 (pKa)
- 6.29±0.70(Predicted)
- InChIKey
- STUWGJZDJHPWGZ-LBPRGKRZSA-N
- SMILES
- N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 29341000 |
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그림문자(GHS): | |||||||||||||||
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신호 어: | Danger | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Alpelisib (BYL719) C화학적 특성, 용도, 생산
개요
BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.용도
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibit or for the treatment of proliferative diseases.Alpelisib (BYL719) 준비 용품 및 원자재
원자재
Acetamide,N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-
4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine
1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol
1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl methanesulfonate
N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-iMidazole-1-carboxaMide
phenyl 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-ylcarbamate
L-Prolinamide
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one
2-Acetyl-4-methylpyridine
2,4-루티딘
준비 용품
Alpelisib (BYL719) 공급 업체
글로벌( 216)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 |
sales@yutbon.com | China | 437 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Alpelisib (BYL719) 관련 검색:
D-ERYTHRO-SPHINGOSINE
BKM120 (NVP-BKM120, Buparlisib)
MK-2206 2HCl
CAL-101
Trametinib
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
BEZ235 (NVP-BEZ235, Dactolisib)
KU-55933
Selumetinib
BML-275
PLX-4720
CX-4945
Fluoxetine hydrochloride
Tubastatin A hydrochloride
N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride
BI 2536
Neratinib
Glucagon Receptor Antagonist I