ILIMAQUINONE C화학적 특성, 용도, 생산
개요
Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-
HIV, anti-
mitotic, and anti-
inflammatory properties. In mammalian cells, 25 μM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-
adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC
50 = 40 μM). Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC
50 = 45.2 and 92 μM, respectively) and, at 10 μM, activates gene expression through hypoxia-
inducible factor-
1.
용도
Ilimaquinone is an ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor.
정의
ChEBI: A natural product found in Dactylospongia elegans.
일반 설명
A cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1.
ILIMAQUINONE 준비 용품 및 원자재
원자재
준비 용품
