FR 122047 HYDROCHLORIDE

FR 122047 HYDROCHLORIDE 구조식 이미지
카스 번호:
130717-51-0
상품명:
FR 122047 HYDROCHLORIDE
동의어(영문):
FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
CBNumber:
CB6178619
분자식:
C23H26ClN3O3S
포뮬러 무게:
459.99
MOL 파일:
130717-51-0.mol
MSDS 파일:
SDS

FR 122047 HYDROCHLORIDE 속성

저장 조건
2-8°C
용해도
염화메틸렌: 50 mg/m, 약간 흐릿함, 노란색
물리적 상태
가루
색상
희미한 노란색
수용성
Soluble to 10 mM in water

안전

안전지침서 22-24/25
WGK 독일 3

FR 122047 HYDROCHLORIDE C화학적 특성, 용도, 생산

개요

FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

용도

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

생물학적 활성

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

FR 122047 HYDROCHLORIDE 준비 용품 및 원자재

원자재

준비 용품


FR 122047 HYDROCHLORIDE 공급 업체

글로벌( 35)공급 업체
공급자 전화 이메일 국가 제품 수 이점
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63711 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131981 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15848 69
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4428 55
ATK CHEMICAL COMPANY LIMITED 3429815786 13301662590
sales@atkchemical.com China 10007 55
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551
15151849396@163.com China 997 58

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