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FR 122047 HYDROCHLORIDE

FR 122047 HYDROCHLORIDE structure

CAS No.: 130717-51-0

Chemical Name:: FR 122047 HYDROCHLORIDE

Synonyms: FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE

CBNumber:: CB6178619

Molecular Formula:: C23H26ClN3O3S

Molecular Weight:: 459.99

MDL Number:: MFCD00925604

MOL File:: 130717-51-0.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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FR 122047 HYDROCHLORIDE Properties

storage temp.	2-8°C
solubility	methylene chloride: 50 mg/mL, slightly hazy, yellow
form	powder
color	faint yellow
Water Solubility	Soluble to 10 mM in water

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

FR 122047 HYDROCHLORIDE price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F7553	FR 122047 hydrochloride ≥98% (HPLC), powder	130717-51-0	25mg	$693	2024-03-01	Buy
Sigma-Aldrich	236005	COX-1 Inhibitor, FR122047	130717-51-0	5mg	$259	2024-03-01	Buy
Cayman Chemical	10039	FR122047 (hydrochloride)	130717-51-0	5mg	$78	2024-03-01	Buy
Cayman Chemical	10039	FR122047 (hydrochloride)	130717-51-0	50mg	$606	2024-03-01	Buy
Cayman Chemical	10039	FR122047 (hydrochloride)	130717-51-0	1mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
F7553	25mg	$693	Buy
236005	5mg	$259	Buy
10039	5mg	$78	Buy
10039	50mg	$606	Buy
10039	1mg	$32	Buy

FR 122047 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

Uses

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

storage

Desiccate at +4°C

FR 122047 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

FR 122047 HYDROCHLORIDE Suppliers

Global( 35)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ATK CHEMICAL COMPANY LIMITED	3429815786 13301662590	sales@atkchemical.com	China	10007	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	997	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Guangzhou Isun Pharmaceutical Co., Ltd	55
ATK CHEMICAL COMPANY LIMITED	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58

FR 122047 HYDROCHLORIDE Spectrum

FR 122047 HYDROCHLORIDE(130717-51-0)¹HNMR

130717-51-0(FR 122047 HYDROCHLORIDE)Related Search:

4,5-DIPHENYL-2-METHYLTHIAZOLE 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE 4-PHENYL-THIAZOLE-2-CARBALDEHYDE (4-METHYL-1,3-THIAZOL-2-YL)METHYLAMINE FR 122047 HYDROCHLORIDE

N-Methylthiazole-2-methanamine C-(4-PHENYL-THIAZOL-2-YL)-METHYLAMINE 5-Methyl-1,3-thiazole-2-carboxaldehyde 1,3-Thiazole-2-carbaldehyde 1-THIAZOL-2-YLMETHYL-PIPERAZINE

4-METHYL-2-THIAZOLECARBOXALDEHYDE 97 1,3-Thiazole-2-carboxamide 2-AMINOMETHYLTHIAZOLE HYDROCHLORIDE 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYL-PIPERAZINE, MONOHYDROCHLORIDE HYDRATE

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4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE 4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE 1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE FR 122047 FR 122047 HYDROCHLORIDE FR122047HCl (4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride (4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl Methanone, [4,5-bis(4-methoxyphenyl)-2-thiazolyl](4-methyl-1-piperazinyl)-, hydrochloride (1:1) 5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole 5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine [4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem FR 122047 hydrochloride,Cyclooxygenase,FR 122047,FR122047,inhibit,Inhibitor,COX,FR-122047 130717-51-0 C23H25N3O3SHCl A to C Biochemicals and Reagents BioChemical Cyclooxygenase Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Enzyme Prostanoid receptor and related