WIN 55,212-2 MESYLATE
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WIN 55,212-2 MESYLATE 속성
- 저장 조건
- Store at +4°C
- 용해도
- 0.1M HCl: 0.25mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- 안정성
- 최대 3개월 동안 -20°의 DMSO에 보관
- InChIKey
- FSGCSTPOPBJYSX-OZYVVJTJNA-N
- SMILES
- S(O)(=O)(=O)C.C(N1CCOCC1)[C@@H]1COC2=CC=CC3C(C(C4=CC=CC5=CC=CC=C45)=O)=C(C)N1C=32 |&1:12,r|
안전
| WGK 독일 | 3 |
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WIN 55,212-2 MESYLATE C화학적 특성, 용도, 생산
개요
(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 μM.용도
(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.일반 설명
WIN 55,212-2 is a member of the aminoalkylindole class of compounds.생물학적 활성
Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .WIN 55,212-2 MESYLATE 준비 용품 및 원자재
원자재
준비 용품
WIN 55,212-2 MESYLATE 공급 업체
글로벌( 150)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 |
fanfan@kangcang.com.cn | China | 340 | 58 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| TopScience Biochemical | 00852-68527855 |
info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 6710 | 58 |
WIN 55,212-2 MESYLATE 관련 검색:
SB216763
WIN 54461
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2-Methylindole-3-carboxaldehyde
1-Ethyl-2-methylindole
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3-Acetylindole
3-Morpholinopropanol
1,2-Dimethylindole
1,2-DIMETHYL-1H-INDOLE-3-CARBOXALDEHYDE
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[1-[2-(4-Morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenylmethanone
1-(1-ETHYL-1H-INDOL-3-YL)ETHANONE
2-(1H-PYRROL-1-YL)-1-ETHANAMINE
ASISCHEM W99822
2-(1H-INDOL-1-YL)ETHANAMINE
2-(2-METHYL-1H-INDOL-1-YL)ETHANAMINE