AGOMELATINE
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AGOMELATINE 속성
- 녹는점
- 107-109°C
- 끓는 점
- 478.8±28.0 °C(Predicted)
- 밀도
- 1.109±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >50mg/mL
- 산도 계수 (pKa)
- 16.17±0.46(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- Merck
- 14,190
- InChI
- InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
- InChIKey
- YJYPHIXNFHFHND-UHFFFAOYSA-N
- SMILES
- C(NCCC1=C2C(C=CC(OC)=C2)=CC=C1)(=O)C
- CAS 데이터베이스
- 138112-76-2(CAS DataBase Reference)
AGOMELATINE C화학적 특성, 용도, 생산
개요
Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin . It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPγS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C (Kis = 0.26 and 0.71 nM, respectively, for the human receptors). Agomelatine (40 mg/kg) inhibits the penile erection response induced by the 5-HT2 agonist Ro 60-0175 in rats. It also increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats when administered at doses ranging from 20 to 80 mg/kg. Agomelatine (10 mg/kg) reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice, indicating antidepressant-like and anxiolytic-like activity, in a transgenic neuroendocrine model of depression. It also increases the rate of readjustment to circadian activity cycles following an induced phase shift.화학적 성질
White Solid용도
Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.AGOMELATINE 준비 용품 및 원자재
원자재
1384536-35-9
185336-04-3
2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride
7-Methoxy-1-naphthylacetonitrile
Agomelatine Impurity 1
2-(7-METHOXYNAPHTHALEN-1-YL)ETHANAMINE
2-(7-Methoxynaphthalen-1-yl)acetamide
준비 용품
AGOMELATINE 공급 업체
글로벌( 600)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Jewim Pharmaceutical (Shandong) Co., Ltd. | +86-15552509998 +86-15621883869 |
liutf@jewim.com.cn | China | 251 | 58 |
| Hebei Bonster Technology Co.,Limited | +8613315996897 |
bsterltd.wendy@gmail.com | China | 796 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 |
Ethan@dornechem.com | China | 294 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 |
sales@chembj.net | China | 269 | 58 |
| Hubei Chuyan Biopharmaceutical Co., Ltd | +1-027-87896938 +15172028168 |
chuyan@chuyan.co | China | 24 | 58 |
AGOMELATINE 관련 검색:
트라조돈
2-(7-Hydroxy-1-naphthyl)ethylaMine
2-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)ethan-1-amine
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
Linagliptin
Alogliptin benzoate
Trelagliptin
Vonoprazan fumarate
Trelagliptin succinate
Teneligliptin Hydrobromide
5-Hydroxytryptophan
AgoMelatine (L(+)-Tartaric acid)
AGOMELATINE
2-(7-METHOXYNAPHTHALEN-1-YL)ETHANAMINE
8-METHYL-2-NAPHTHOL
2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride
(E)-N-(2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)ethyl)acetamide
Desacetyl-7-desMethyl AgoMelatine HydrobroMide