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HOMATROPINE METHYL BROMIDE

HOMATROPINE METHYL BROMIDE 구조식 이미지
카스 번호:
80-49-9
상품명:
HOMATROPINE METHYL BROMIDE
동의어(영문):
sethyl;ESOPIN;D02070;homapin;mesopin;Equipin;novatrin;sed-tems;HOMOLONE;endo-mid
CBNumber:
CB9114740
분자식:
C17H24BrNO3
포뮬러 무게:
370.28
MOL 파일:
80-49-9.mol

HOMATROPINE METHYL BROMIDE 속성

녹는점
192°C
용해도
Freely soluble in water, soluble in ethanol 96 per cent
물리적 상태
neat
Merck
14,4730
CAS 데이터베이스
80-49-9(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 20/21/22
안전지침서 22-26-36
유엔번호(UN No.) 1544
WGK 독일 3
RTECS 번호 MS9000000
위험 등급 6.1
포장분류 III
HS 번호 29399990
독성 LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:

HOMATROPINE METHYL BROMIDE C화학적 특성, 용도, 생산

화학적 성질

White or almost white, crystalline powder or colourless crystals

용도

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

용도

anticholinergic (opthalmic)

상표명

Equipin (Mission); Homapin (Mission).

일반 설명

Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).

Clinical Use

Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.

HOMATROPINE METHYL BROMIDE 준비 용품 및 원자재

원자재

준비 용품


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