ChemicalBook >제품 카탈로그 >생화학 공학>억제제>DNA 손상>DNA-PK 억제제>KU57788(NU7441)

KU57788(NU7441)

KU57788(NU7441) 구조식 이미지

카스 번호:: 503468-95-9

상품명:: KU57788(NU7441)

동의어(영문):: CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441;NU 7441 (This product is only available in Japan.)

CBNumber:: CB92500947

분자식:: C25H19NO3S

포뮬러 무게:: 413.49

MOL 파일:: 503468-95-9.mol

속성

안전

용도

공급 업체 127

KU57788(NU7441) 속성

녹는점: 220-221 °C

끓는 점: 646.9±55.0 °C(Predicted)

밀도: 1.376±0.06 g/cm3(Predicted)

저장 조건: Store at +4°C

용해도: DMSO에 용해됩니다(가온 시 최대 10mg/ml).

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 0.51±0.20(Predicted)

색상: 미색부터 베이지까지

안정성: 공급된 대로 1년 동안 안정적입니다. DMSO의 솔루션은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

안전

KU57788(NU7441) C화학적 특성, 용도, 생산

개요

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC₅₀ value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC₅₀ values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

KU57788(NU7441) 준비 용품 및 원자재

원자재

준비 용품

KU57788(NU7441) 공급 업체

글로벌( 127)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

KU57788(NU7441) 관련 검색:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Levetiracetam N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) BI 2536 CHLOROPICRIN & ETHYLENE DIBROMIDE Indole Dibenzofuran Bortezomib NU7026 KU-55933 (ATM Kinase Inhibitor) VE-821 Ibrutinib Olaparib