톨라자마이드
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톨라자마이드 속성
- 녹는점
- 162-164°C
- 끓는 점
- 300°C (rough estimate)
- 밀도
- 1.2228 (rough estimate)
- 굴절률
- 1.6740 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 물에 아주 약간 용해됩니다. 클로로포름에 자유롭게 용해되며; 아세톤에 용해됨; 에탄올(96%)에 약간 용해됩니다.
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 3.6(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 65.4mg/L(30℃)
- CAS 데이터베이스
- 1156-19-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22 | ||
안전지침서 | 36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | YT4400000 | ||
HS 번호 | 2935904000 | ||
유해 물질 데이터 | 1156-19-0(Hazardous Substances Data) | ||
독성 | LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin) |
톨라자마이드 C화학적 특성, 용도, 생산
개요
Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 μM in HEK293 cells transfected with the human receptor). It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin. In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin . Formulations containing tolazamide have been used in the treatment of type 2 diabetes.화학적 성질
White Solid용도
Labelled Tolazamide, an antidiabetic.정의
ChEBI: An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.일반 설명
Tolazamide is N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide; or 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; or 1-(4-methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea (generic).Tolazamide incorporates a fully saturated azepine moietythat is but weakly basic, with a pKa of~3.32 The pKa of thesulfonylurea group lies within the typical range; thus, inareas of the duodenum wherein the pH falls within the rangeof 4 to 5, the uncharged form of the drug is the predominantspecies, and its lipophilicity lends to rapid absorption bypassive diffusion.공기와 물의 반응
TOLAZAMIDE may be sensitive to prolonged exposure to air. Insoluble in water.반응 프로필
TOLAZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLAZAMIDE is incompatible with acids. .화재위험
Flash point data for TOLAZAMIDE are not available; however, TOLAZAMIDE is probably combustible.톨라자마이드 준비 용품 및 원자재
원자재
준비 용품
톨라자마이드 공급 업체
글로벌( 138)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29822 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |
톨라자마이드 관련 검색:
1-아미노호모피페리딘 톨라자마이드
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Levodopa
TOLBUTAMIDE
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CHLORPROPAMIDE
Miglitol
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Phentolamine mesilate
4-Carboxytolbutamide Methyl Ester
Tolbutamide-d9
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4-Methylphenylsulfonylurea
Glidazamide