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TOLAZAMIDE

TOLAZAMIDE
TOLAZAMIDE structure
CAS No.
1156-19-0
Chemical Name:
TOLAZAMIDE
Synonyms
U-17835;tolinase;tolanase;Tolonase;diabewas;nsc-70762;norglycin;TOLAZAMIDE;nci-c03327;tolazolamide
CBNumber:
CB9355686
Molecular Formula:
C14H21N3O3S
Formula Weight:
311.4
MOL File:
1156-19-0.mol

TOLAZAMIDE Properties

Melting point:
162-164°C
Boiling point:
300°C (rough estimate)
Density 
1.2228 (rough estimate)
refractive index 
1.6740 (estimate)
storage temp. 
Refrigerator
solubility 
Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).
pka
3.6(at 25℃)
CAS DataBase Reference
1156-19-0(CAS DataBase Reference)

SAFETY

Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  YT4400000
Toxicity LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin)

TOLAZAMIDE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1668001 Tolazamide United States Pharmacopeia (USP) Reference Standard 1156-19-0 200mg $352.8 2018-11-20 Buy
Cayman Chemical 23545 Tolazamide ≥98% 1156-19-0 5mg $55 2018-11-19 Buy
Cayman Chemical 23545 Tolazamide ≥98% 1156-19-0 10mg $99 2018-11-19 Buy
Cayman Chemical 23545 Tolazamide ≥98% 1156-19-0 25mg $220 2018-11-19 Buy
Cayman Chemical 23545 Tolazamide ≥98% 1156-19-0 50mg $385 2018-11-19 Buy

TOLAZAMIDE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Labelled Tolazamide, an antidiabetic.

Uses

Tolazamide

Definition

ChEBI: An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.

General Description

Tolazamide is N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide; or 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; or 1-(4-methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea (generic).Tolazamide incorporates a fully saturated azepine moietythat is but weakly basic, with a pKa of~3.32 The pKa of thesulfonylurea group lies within the typical range; thus, inareas of the duodenum wherein the pH falls within the rangeof 4 to 5, the uncharged form of the drug is the predominantspecies, and its lipophilicity lends to rapid absorption bypassive diffusion.

General Description

Tolazamide, 1-(hexahydro-1Hazepin-1-yl)-3-(p-tolylsulfonyl)urea (Tolinase), is an analogof tolbutamide and is reported to be effective, in general,under the same circumstances in which tolbutamide is useful.Tolazamide, however, appears to be more potent than tolbutamideand is nearly equal in potency to chlorpropamide. Instudies with radioactive tolazamide, investigators found that85% of an oral dose appeared in the urine as metabolites thatwere more soluble than tolazamide itself.

General Description

White to off-white crystalline powder. Odorless or with a slight odor.

Air & Water Reactions

TOLAZAMIDE may be sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

TOLAZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLAZAMIDE is incompatible with acids. .

Fire Hazard

Flash point data for TOLAZAMIDE are not available; however, TOLAZAMIDE is probably combustible.

TOLAZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products


TOLAZAMIDE Suppliers

Global( 61)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32451 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24195 60
Hubei Jusheng Technology Co.,Ltd.
8615527864001
sales@jushengtech.com CHINA 20084 58
Hubei xin bonus chemical co. LTD
8613657299721
sales@xhlchem.com CHINA 17428 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32363 50
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771
sales@heowns.com China 14462 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9851 79
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 mkt@spectrumchina.net China 9690 60

1156-19-0(TOLAZAMIDE)Related Search:


  • nsc-70762
  • tolanase
  • tolazolamide
  • tolinase
  • SALOR-INT L254916-1EA
  • N-[[(HEXAHYDRO-1H-AZEPINYL)AMINO]CARBONYL]-4-METHYLBENZENESULFONAMIDE
  • U-17835
  • TOLAZAMIDE
  • LABOTEST-BB LT00772329
  • 1-[HEXAHYDRO-1H-AZEPIN-1-YL]-3-[P-TOLUENESULFONYL]UREA
  • Tolonase
  • Tolazamide (200 mg)
  • 1-(hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
  • 1-(hexahydro-1h-azepin-1-yl)-3-(p-tolylsulfonyl)-ure
  • 1-(hexahydro-1h-azepin-1-yl)-3-(p-tolylsulfonyl)urea
  • 4-(p-tolylsulfonyl)-1,1-hexamethylenesemicarbazide
  • diabewas
  • n-(((hexahydro-1h-azepin-1-yl)-amino)carbonyl)-4-methyl-benzenesulfonamid
  • n-(p-toluenesulfonyl)-n’-hexamethyleniminourea
  • n,((hexahydro-1h-azepin-1-yl)amino)carbonyl)-4-methyl-benzenesulfonamid
  • n-[[(hexahydro-1h-azepin-1-yl)-amino]carbonyl]-4-methylbenzenesulfonamide
  • nci-c03327
  • norglycin
  • Tolazamide Solution, 100ppm
  • 1156-19-0
  • C14H21N3O3S
  • Stimulates pancreatic islet cells to secrete insulin; blocks ATP-sensitive K+ channels.
  • Voltage-gated Ion Channels
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • TOLINASE
  • Potassium Channel Modulators
  • Ion Channels
  • Monovalent Ion Channels
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
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